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Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
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Why human connection is the true metric of research success
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Front Matter Al Ulum: Journal Of Science And Technology Vol. 10, No. 3, December 2024
Front Matter
doaj
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Public finance and public choice [PDF]
Public finance has undergone major transformation since World War II. This paper surveys this transformation, particularly from a public-choice perspective.
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Theodore Roosevelt: Publicity! Publicity! Publicity!
1998Theodore Roosevelt, who succeeded William McKinley in 1901, accelerated the transformation of presidential leadership that McKinley had begun. Roosevelt’s masterful management of the press to generate news coverage of himself and his policies long has been recognized.1 One study suggests that Roosevelt received the longest press “honeymoon” and the ...
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