Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Efficient Distribution-Based Event Filtering [PDF]
, 2002 Event notification services are used in various applications, for example, stock tickers, environmental monitoring, and facility management. Several filtering algorithms for such services have been proposed.
Bittner, Sven, Hinze, Annika
core +1 more source
An Efficient Scheme for Aggregation and Presentation of Network Performance in Distributed Brokering Systems [PDF]
Journal of Systemics, Cybernetics and Informatics, 2003 The Internet is presently being used to support increasingly complex interaction models as a result of more and more applications, services and frameworks becoming network centric.
Gurhan Gunduz +2 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Reliability and timeliness analysis of content-based publish/subscribe systems [PDF]
, 2010 Content-based Publish/subscribe systems (CBPS) is a simple yet powerful communication paradigm. Its content-centric nature is suitable for a wide spectrum of today's content-centric applications such as stock market quote exchange, remote monitoring and ...
Pongthawornkamol, Thadpong +1 more
core
Transparent End-to-End Security for Publish/Subscribe Communication in Cyber-Physical Systems
, 2021 S.78-87The ongoing digitization of industrial manufacturing leads to a decisive change in industrial communication paradigms. Moving from traditional one-to-one to many-to-many communication, publish/subscribe systems promise a more dynamic and efficient
Martin Henze +17 more
core +1 more source
Tail Latency Amplification in ROS 2 Publish–Subscribe Communication Under Subscriber Fan-Out
MathematicsROS 2 employs a publish–subscribe communication model widely used in robotic and distributed systems. As subscriber counts increase, system-level resource contention may influence latency behavior beyond simple message delivery costs.
MinGi Kyung
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Specifying and detecting composite events in content-based publish/subscribe systems
, 2002 Content-based publish/subscribe systems mediate between publishers of information and subscribers who sign up to receive information, by routing messages across the network from their source of publication to the point of subscription using the message ...
Courtenage, S., S. Courtenage
core +1 more source
Survey of Publish Subscribe Event Systems [PDF]
, 2003 The Internet has changed considerably the scale of distributed systems, motivating the demand for more flexible communication models and systems.
Liu, Ying; Plale, Beth
core +1 more source