Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Making scientific publishing more balanced and reversing the current dangerous drift to better support global environmental conservation and planetary health. [PDF]
Guidetti P +4 more
europepmc +1 more source
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
The Challenges of Scientific Publishing: An Editor-In-Chief's Perspective. [PDF]
Zimmer L, Bousquet P.
europepmc +1 more source
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Correcting the record on "Publication integrity and industry influences on the editorial process: a case study". [PDF]
Rathmell JP.
europepmc +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
AI in academia: navigating ethical crossroads of innovation, integrity, and equity. [PDF]
Talebi Bezmin Abadi A.
europepmc +1 more source
75 Years of Adventure in Turkish Scientific Medical Publishing: From <i>Istanbul Contribution to Clinical Science</i> to <i>Turkish Journal of Hematology</i> (1951-2026) [PDF]
Demir AM.
europepmc +1 more source

