Results 41 to 50 of about 336,243 (295)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Snap-through and pull-in instabilities of an arch-shaped beam under an electrostatic loading

, 2007
The snap-through and pull-in instabilities of the micromachined arch-shaped beams under an electrostatic loading are studied both theoretically and experimentally. The pull-in instability that results in a system collision with an electrode substrate may
Zhang, Y (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100080, Peoples R China., 张吟, Wang YS, Huang YB, Li DC, Li ZH   +5 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Nonlinear dynamics in MEMS systems: Overcoming pull-in challenges and exploring innovative solutions

Journal of Low Frequency Noise, Vibration and Active Control
Micro-Electro-Mechanical Systems (MEMS) play a pivotal role in modern technology, with applications ranging from biomedical monitoring to inertial navigation, RF communication, and energy harvesting.
Chun-Hui He, Yutong Cui, Ji-Huan He, Eerdun Buhe, Qingmei Bai, Qiu Xu, Jinfeng Ma, Abdulrahman Ali Alsolam, Meigeng Gao   +8 more
doaj   +1 more source

Modeling a Pull-In Instability in Micro-Machined Hybrid Contactless Suspension

Actuators, 2018
A micro-machined hybrid contactless suspension, in which a conductive proof mass is inductively levitated within an electrostatic field, is studied.
Kirill V. Poletkin, Jan G. Korvink
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

SIZE EFFECT ON THE SNAP-THROUGH AND PULL-IN INSTABILITY OF THE ELECTROSTATICALLY ACTUATED MICRO SHALLOW ARCH

Jixie qiangdu, 2019
The snap-through and pull-in instability of the electrostatically actuated micro shallow arches incorporating Casimir force was investigated based on the modified couple stress theory. The nonlinear governing equation and boundary conditions were derived
YUAN YanQi, KONG ShengLi, LU Fei
doaj  

Dynamic Pull-in Instability of Nano-Actuators in the Presence of a Dielectric Layer [PDF]

Journal of Optoelectronical Nanostructures, 2016
The natural frequency and pull-in instability of clamped-clamped nano-actuators in the presence of a dielectric layer are analyzed. The influence of the presence of Casimir force, electrostatic force, fringing field effect, axial force, stretching ...
Mohammad Ghalambaz, Ali J Chamkha, Mehdi Ghalambaz, Mohammad Edalatifar   +3 more
doaj  

A flexible model for studying fringe field effect on parallel plate actuators

Journal of Electrical Systems and Information Technology, 2020
Electrostatic parallel plate actuators are common in micro-electro-mechanical systems due to their compatibility with micro-fabrication technology. Parallel plate actuators suffer from an instability problem called the pull-in phenomenon that happens ...
Ahmad Elshenety, E. E. El-Kholy, Ahmed F. Abdou, Mostafa Soliman, Mohsen M. Elhagry   +4 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source