Results 51 to 60 of about 336,341 (295)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Wrinkling and pull-in instabilities of circular dielectric elastomer actuators [PDF]

SCIENTIA SINICA Physica, Mechanica & Astronomica, 2011
When subject to an electric field, a dielectric elastomer (DE) deforms, possibly straining over 100%. Due to their distinctive mechanical properties, the DEs are being developed as actuators for broad applications, such as armaria, adaptive optics, and robots.
HuaDong YONG, YouHe ZHOU, Jing XIA
openaire   +1 more source

Pull-in instability of geometrically nonlinear micro-switches under electrostatic and Casimir forces [PDF]

, 2011
This paper investigates the pull-in instability of micro-switches under the combined electrostatic and intermolecular forces and axial residual stress, accounting for the force nonlinearity and geometric nonlinearity which stems from mid-plane stretching.
Jia Xiao Li (19990911), Jie Yang (18030766), Sritawat Kitipornchai (16974660)   +2 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Pull-in instability behaviour of nanoscale actuators using nonlocal elasticity theory [PDF]

, 2012
This paper modified the linear distributed load (LDL) model for cantilever nano-beams. A linear load model which suits boundary conditions was proposed to approximate with nonlinear intermolecular and electrostatic interactions. In the modified LDL model,
Liu Yang (23752), Jian-She Peng (19994340), Guangbing Lou (19994343), Jie Yang (18030766)   +3 more
core  

Nonlinear dynamics in MEMS systems: Overcoming pull-in challenges and exploring innovative solutions

Journal of Low Frequency Noise, Vibration and Active Control
Micro-Electro-Mechanical Systems (MEMS) play a pivotal role in modern technology, with applications ranging from biomedical monitoring to inertial navigation, RF communication, and energy harvesting.
Chun-Hui He, Yutong Cui, Ji-Huan He, Eerdun Buhe, Qingmei Bai, Qiu Xu, Jinfeng Ma, Abdulrahman Ali Alsolam, Meigeng Gao   +8 more
doaj   +1 more source

Modeling a Pull-In Instability in Micro-Machined Hybrid Contactless Suspension

Actuators, 2018
A micro-machined hybrid contactless suspension, in which a conductive proof mass is inductively levitated within an electrostatic field, is studied.
Kirill V. Poletkin, Jan G. Korvink
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

SIZE EFFECT ON THE SNAP-THROUGH AND PULL-IN INSTABILITY OF THE ELECTROSTATICALLY ACTUATED MICRO SHALLOW ARCH

Jixie qiangdu, 2019
The snap-through and pull-in instability of the electrostatically actuated micro shallow arches incorporating Casimir force was investigated based on the modified couple stress theory. The nonlinear governing equation and boundary conditions were derived
YUAN YanQi, KONG ShengLi, LU Fei
doaj