Results 131 to 140 of about 54,253 (241)

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Preclinical Quantitative In Vivo MRI Assessment of Exogenous Surfactant Pulmonary Distribution After Clinically Relevant Intratracheal Delivery

NMR in Biomedicine, Volume 39, Issue 6, June 2026.
Quantitative in vivo contrast‐enhanced UTE MRI enables sensitive and precise mapping of pulmonary surfactant distribution, revealing peripheral localization and homogeneous distal penetration under physiological conditions. Comparison with ex vivo models highlights the role of physiological processes in surfactant retention.
Oumaima Marfouk, Rémy Gérard, Ghalia Kaouane, Lara Leclerc, Noël Pinaud, Michael Fayon, Sophie Périnel‐Ragey, Jérémie Pourchez, Eric Dumas De La Roque, Yannick Crémillieux   +9 more
wiley   +1 more source

Keeping it together: Pulmonary alveoli are maintained by a hierarchy of cellular programs. [PDF]

Bioessays, 2015
Logan CY, Desai TJ.
europepmc   +1 more source

Sidestream-dark field videomicroscopy for the in vivo evaluation of the pulmonary alveoli and microcirculation in mechanically ventilated pigs [PDF]

Introduction: Under mechanical ventilation, the pulmonary microcirculation can be affected by the expansion or collapse of alveoli, resulting in a change in pulmonary vascular resistance.
Casarotta, Erika, Tambella, Adolfo Maria, Zuccari, Samuele, Galosi, Margherita, Di Bella, Caterina, Serino, Federica, Damiani, Elisa, Angorini, Alessio, Donati, Abele   +8 more
core  

Recurrent Pneumothorax Following Multilevel Posterior Spinal Fixation in a Patient With Pre‐Existing Pulmonary Contusion: A Case Report

Respirology Case Reports, Volume 14, Issue 6, June 2026.
We report a life‐threatening recurrent pneumothorax in a polytrauma patient following posterior spinal fixation, triggered by the physiological stress of prone positioning and positive pressure ventilation on a pre‐existing pulmonary contusion. This case highlights the critical risk of early chest tube removal and advocates for maintaining pleural ...
Parisa Mirzaei, Zahra Baghani, Mohammad Javad Mousavi   +2 more
wiley   +1 more source

Sympatho‐Excitation in Pulmonary Hypertension: The Potential Role of Pulmonary Arterial Baroreceptors: An Acute Physiologic Intervention Study

Respirology, Volume 31, Issue 6, Page 621-629, June 2026.
Pulmonary arterial baroreceptors reflexively stimulate sympathetic nerve activity (SNA) in response to elevated pulmonary artery pressure and distension. In pulmonary hypertension patients, changes in muscle SNA were proportional to changes in pulmonary haemodynamics following nebulised iloprost.
Michael J. Plunkett, Ana L. C. Sayegh, Robert A. Lewis, Tanya J. McWilliams, Sasiharan Sithamparanathan, Julian F. R. Paton, James P. Fisher   +6 more
wiley   +1 more source

Lactobacillus paracasei L9 Ameliorates Pulmonary Fibrosis in Aged Mice via Gut‐Lung Axis‐Mediated Regulation of Immune Cell Migration

Aging Cell, Volume 25, Issue 6, June 2026.
Oral administration of Lactobacillus paracasei L9 (L9) reshapes the gut microbiota, specifically increasing the abundance of short‐chain fatty acid (SCFA)‐producing bacteria (e.g., Blautia), thereby leading to a significant elevation of serum propionic acid (97% increase) and butyric acid (193% increase).
Ran Bi, Yiran Zhang, Wen Zhang, Chenhong Shi, Ziyu Qiao, Rui Quan, Yanan Sun, Juan Chen, Ran Wang, Fazheng Ren, Yixuan Li   +10 more
wiley   +1 more source

Nanomedicine in pulmonary delivery

, 2009
Heidi M Mansour, Yun-Seok Rhee, Xiao WuUniversity of Kentucky, College of Pharmacy, Division of Pharmaceutical Sciences-Drug Development Division, Lexington, KY, USAAbstract: The lung is an attractive target for drug delivery due to noninvasive ...
Xiao Wu, Heidi M Mansour, Yun-Seok Rhee
core  

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

British Journal of Pharmacology, Volume 183, Issue 12, Page 3395-3408, June 2026.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Caterina Frati, Denise Madeddu, Federico Quaini, Costanza Anna Maria Lagrasta, Ilaria Minato, Emanuela Bocchi, Maurizio Civelli, Gino Villetti, Marcello Trevisani, Barbara Montanini   +14 more
wiley   +1 more source

Respiratory Biomarkers: An Opportunity for Patient‐Centric Microsampling Approach for Treatment Optimization

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
Overview of patient centric microsampling approach for monitoring respiratory biomarkers for treatment optimization. Image created in BioRender. Khan, A. (2026) https://BioRender.com/17jm5cs. ABSTRACT The clinical heterogeneity of respiratory disorders emphasizes the need for personalized approaches to prevention, diagnosis, and therapy.
Ahmar Khan, Jacqueline L. Stair, Daniel Baker, Neil Spooner, Darragh Murnane   +4 more
wiley   +1 more source