Results 111 to 120 of about 54,253 (241)

Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia

Current Issues in Molecular Biology
Pneumonia is a severe lower respiratory tract infection. This study demonstrates that phospholipase A2 (PLA2), a potential biomarker for pneumonia, contributes to alveoli damage by hydrolyzing pulmonary surfactant phospholipids.
Jianyu Wang, Huanchun Xing, Lin Wang, Zhongxing Xu, Xin Sui, Yuan Luo, Jun Yang, Yongan Wang   +7 more
doaj   +1 more source

Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats

, 1996
Dexamethasone, a glucocorticosteroid hormone, inhibits the formation of alveoli; retinoids and glucocorticosteroid hormones can be mutually antagonistic.
G. D. Massaro, D. Massaro
core   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis

Stem Cells and Cloning: Advances and Applications, 2023
Amrita Vats,1 Pankaj Chaturvedi2 1Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, IL, 60612, USA; 2Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801 ...
Vats A, Chaturvedi P
doaj  

Signaling Pathways Involved in the Development of Bronchopulmonary Dysplasia and Pulmonary Hypertension

, 2020
The alveolar and vascular developmental arrest in the premature infants poses a major problem in the management of these infants. Although, with the current management, the survival rate has improved in these infants, but bronchopulmonary dysplasia (BPD)
Rajamma Mathew, Mathew, Rajamma
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Intra-operative assessment of human pulmonary alveoli in vivo using Sidestream Dark Field imaging: a feasibility study

, 2009
BACKGROUND: In vivo videomicroscopy has been used for years to visualize subpleural alveoli in animal studies. This has led to a better understanding of alveolar physiology.
Dos Reis Miranda, Dinis, Hartman, JM, Simoons, Maarten, Bezemer, R, Bogers, Ad; id_orcid, Spronk, PE, Bezemer, Rick, Hartman, Michael, den Uil, Corstiaan A., Lagrand, Wim K., Lagrand, WK, Uil, Corstiaan, Ince, Can, Spronk, Peter E., Bogers, Ad J., Simoons, Maarten L., Miranda, Dinis R.   +16 more
core  

Modeling for artificial respiration: flow in the pulmonary capillary network and interaction of alveoli

, 2012
Wenn Menschen künstlich beatmet werden müssen, übernimmt ein Atemgerät die Funktion der Atemmuskulatur und pumpt Luft in die Lunge. Die Hauptaufgabe der künstlichen Beatmung ist es, den Austausch von Sauerstoff und Kohlendioxid zu gewährleisten ...
Schirrmann, Kerstin
core   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1685-1695, June 2026.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source