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Pulmonary arterial hypertension [PDF]
Orphanet Journal of Rare Diseases, 2013 Pulmonary arterial hypertension (PAH) is a chronic and progressive disease leading to right heart failure and ultimately death if untreated. The first classification of PH was proposed in 1973. In 2008, the fourth World Symposium on PH held in Dana Point
D. Montani +12 more
semanticscholar +9 more sources
PULMONARY ARTERIAL HYPERTENSION [PDF]
Annals of Medicine, 2006 Pulmonary arterial hypertension is a disease of the small pulmonary arteries characterized by vascular narrowing and increased pulmonary vascular resistance, which eventually leads to right ventricular failure. Vasoconstriction, vascular proliferation, remodeling of the pulmonary vessels, and thrombosis are all contributing factors to the increased ...
Joseph Loscalzo, Azad Raiesdana
+13 more sources
Pulmonary arterial hypertension [PDF]
Medicina, 2007 Pulmonary arterial hypertension is a life-threatening, progressive disorder of pulmonary blood vessels leading to an increase in pressure in pulmonary artery. Diagnosis is based on a mean pulmonary artery pressure of more than 25 mmHg at rest or more than 30 mmHg during exercise. No cure exists for it yet.
Harry L. Messmore +3 more
+9 more sources
Pulmonary arterial hypertension [PDF]
Internal and Emergency Medicine, 2009 In Internal and Emergency Medicine, Wu and coworkers [1] review the topic of pulmonary arterial hypertension. Overall, their article is sound and pertinent; however, some issues deserve comments. First, the value of chest radiography in the diagnostic process is somewhat overlooked.
Aydin Uzunpinar, Mehmet Cilingiroglu
+11 more sources
Sotatercept for the Treatment of Pulmonary Arterial Hypertension.
New England Journal of Medicine, 2021 BACKGROUND Pulmonary arterial hypertension is characterized by pulmonary vascular remodeling, cellular proliferation, and poor long-term outcomes.
M. Humbert +17 more
semanticscholar +1 more source
Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension
European Respiratory Journal, 2022 Background In participants with pulmonary arterial hypertension, 24 weeks of sotatercept resulted in a significantly greater reduction from baseline in pulmonary vascular resistance than placebo.
M. Humbert +16 more
semanticscholar +1 more source
Pulmonary arterial hypertension [PDF]
Breathe, 2005 Key pointsPAH is defined by RHC showing a pre-capillary PH.Clinical suspicion of PH should arise in the case of symptoms such as dyspnoea without overt signs of specific heart or lung disease.RHC is required to confirm the diagnosis of PAH, to assess the severity of the haemodynamic impairment and to test the vasoreactivity of the pulmonary circulation.
Xavier Jaïs +5 more
openaire +4 more sources
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
European Respiratory Journal, 2021 Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and development of plexiform lesions.
C. Evans +4 more
semanticscholar +1 more source
Molecular Pathways in Pulmonary Arterial Hypertension
International Journal of Molecular Sciences, 2022 Pulmonary arterial hypertension is a multifactorial, chronic disease process that leads to pulmonary arterial endothelial dysfunction and smooth muscular hypertrophy, resulting in impaired pliability and hemodynamics of the pulmonary vascular system, and
Aangi J Shah, Mounica Vorla, D. Kalra
semanticscholar +1 more source
Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension [PDF]
, 2013 <b>Rationale:</b> MicroRNAs are small non-coding RNAs involved in the regulation of gene expression and have recently been implicated in the development of pulmonary arterial hypertension (PAH).
Baker, Andrew H. +5 more
core +7 more sources