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PULMONARY ARTERIAL HYPERTENSION [PDF]

Annals of Medicine, 2006
Pulmonary arterial hypertension is a disease of the small pulmonary arteries characterized by vascular narrowing and increased pulmonary vascular resistance, which eventually leads to right ventricular failure. Vasoconstriction, vascular proliferation, remodeling of the pulmonary vessels, and thrombosis are all contributing factors to the increased ...
Joseph Loscalzo, Azad Raiesdana
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Pulmonary arterial hypertension [PDF]

Medicina, 2007
Pulmonary arterial hypertension is a life-threatening, progressive disorder of pulmonary blood vessels leading to an increase in pressure in pulmonary artery. Diagnosis is based on a mean pulmonary artery pressure of more than 25 mmHg at rest or more than 30 mmHg during exercise. No cure exists for it yet.
Harry L. Messmore, Donald M. Bers, Jose L. Puglisi, William H. Wehrmacher   +3 more
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Pulmonary arterial hypertension [PDF]

Internal and Emergency Medicine, 2009
In Internal and Emergency Medicine, Wu and coworkers [1] review the topic of pulmonary arterial hypertension. Overall, their article is sound and pertinent; however, some issues deserve comments. First, the value of chest radiography in the diagnostic process is somewhat overlooked.
Aydin Uzunpinar, Mehmet Cilingiroglu
  +10 more sources

Pulmonary arterial hypertension [PDF]

Orphanet Journal of Rare Diseases, 2013
Abstract Pulmonary arterial hypertension (PAH) is a chronic and progressive disease leading to right heart failure and ultimately death if untreated. The first classification of PH was proposed in 1973. In 2008, the fourth World Symposium on PH held in Dana Point (California, USA) revised previous classifications.
Montani, David, Günther, Sven, Dorfmüller, Peter, Perros, Frédéric, Girerd, Barbara, Garcia, Gilles, Jaïs, Xavier, Savale, Laurent, Artaud-Macari, Elise, Price, Laura, Humbert, Marc, Simonneau, Gérald, Sitbon, Olivier   +12 more
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Pulmonary arterial hypertension [PDF]

Breathe, 2005
Key pointsPAH is defined by RHC showing a pre-capillary PH.Clinical suspicion of PH should arise in the case of symptoms such as dyspnoea without overt signs of specific heart or lung disease.RHC is required to confirm the diagnosis of PAH, to assess the severity of the haemodynamic impairment and to test the vasoreactivity of the pulmonary circulation.
Xavier Jaïs, Olivier Sitbon, G. Simonneau, P Hervé, Florence Parent, Marc Humbert   +5 more
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Pulmonary Arterial Hypertension

Journal of the American College of Cardiology, 2008
Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol in 1998. Subsequently, multiple additional medications have received approval, including a subcutaneous prostacyclin, an inhaled prostacyclin, and oral medications in 2 separate classes.
Kelly Chin, Lewis J. Rubin
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Pulmonary artery denervation for pulmonary arterial hypertension

Trends in Cardiovascular Medicine, 2021
Pulmonary arterial hypertension remains a progressive, life-limiting disease despite optimal medical therapy. Pulmonary artery denervation has arisen as a novel intervention in the treatment of pulmonary arterial hypertension, and other forms of pulmonary hypertension, with the aim of reducing the sympathetic activity of the pulmonary circulation.
Constantine, A, Dimopoulos, K
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Schistosomiasis Pulmonary Arterial Hypertension [PDF]

Frontiers in Immunology, 2020
Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic schistosomiasis, particularly due to S. mansoni. The lung blood vessel injury may result from a combination of embolization of eggs through portocaval shunts into the
Virginia Pacheco Guimaraes, Michael H. Lee, Michael H. Lee, Joan F. Hilton, Brian B. Graham, Brian B. Graham, Jean Pierre Sibomana, Jean Pierre Sibomana, Rajesh Kumar, Rajesh Kumar, Ricardo de Amorim Corrêa, Luciana Costa Silva, Edford Sinkala, Aloma Campeche, Camila Farnese Rezende, Camila Loureiro, Jaquelina S. Ota-Arakaki, Roberto J. Carvalho-Filho, Hanan Yusuf Ahmed, Biruk Kassa, Biruk Kassa, Claudia Mickael, Helena Duani, Rudolf K.F. Oliveira, Sula Mazimba   +24 more
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Genetics of Pulmonary Arterial Hypertension [PDF]

Seminars in Respiratory and Critical Care Medicine, 2009
Tremendous progress has been made in understanding the genetics of pulmonary arterial hypertension (PAH) since its description in the 1950s as a primary disorder of the pulmonary vasculature. Heterozygous germline mutations in the gene coding bone morphogenetic receptor type 2 (BMPR2) are detectable in the majority of cases of heritable PAH, and in ...
Joshua D. Chew, Eric D. Austin, James E. Loyd   +2 more
openaire   +4 more sources

The arterial load in pulmonary hypertension [PDF]

European Respiratory Review, 2010
The anatomical differences between the pulmonary and systemic arterial system are the main cause of the difference in distribution of compliance. In the pulmonary arterial system compliance is distributed over the entire arterial system, and stands at the basis of the constancy of the RC-time.
Saouti, N., Westerhof, N., Postmus, P.E., Vonk Noordegraaf, A.   +3 more
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