Results 41 to 50 of about 445,623 (380)
Current and future treatments of pulmonary arterial hypertension
British Journal of Pharmacology, 2020 Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin, and NO pathways has significantly improved outcomes. However, for the vast
N. Sommer +8 more
semanticscholar +1 more source
Impact of the updated hemodynamic definitions on diagnosis rates of pulmonary hypertension
Pulmonary Circulation, 2020 We evaluated whether updated pulmonary hypertension definitive criteria proposed in sixth World Symposium on Pulmonary Hypertension had an impact on diagnosis of overall pulmonary hypertension and pre-capillary and combined pre- and post-capillary ...
Seda Tanyeri +15 more
doaj +1 more source
Clinical heterogeneity of Pulmonary Arterial Hypertension associated with variants in TBX4.
PLoS ONE, 2020 BACKGROUND:The knowledge of hereditary predisposition has changed our understanding of Pulmonary Arterial Hypertension. Genetic testing has been widely extended and the application of Pulmonary Arterial Hypertension specific gene panels has allowed its ...
Ignacio Hernandez-Gonzalez +15 more
doaj +1 more source
Pulmonary Circulation, 2021 Inhalation profiles to support use of dry powder inhalers for drug delivery in patients with pulmonary arterial hypertension have not been reported. We aimed to evaluate the inspiratory flow pattern associated with low and medium flow resistance dry ...
Mariana Faria-Urbina +4 more
doaj +1 more source
Animal Models of Pulmonary Arterial Hypertension and Their Application in Drug Research
Shiyan dongwu yu bijiao yixue, 2023 Pulmonary arterial hypertension is a clinical syndrome characterized by pulmonary vascular remodeling causing increased vascular resistance, which will lead to right heart failure and even death if left untreated.
YU Jiahui, GONG Qian, ZHUANG Lenan
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A Topological Data Analysis Study on Murine Pulmonary Arterial Trees with Pulmonary Hypertension [PDF]
arXiv, 2022 Pulmonary hypertension (PH), defined by a mean pulmonary arterial blood pressure above 20 mmHg, is a cardiovascular disease impacting the pulmonary vasculature. PH is accompanied by vascular remodeling, wherein vessels become stiffer, large vessels dilate, and smaller vessels constrict.
arxiv
Macitentan and morbidity and mortality in pulmonary arterial hypertension.
New England Journal of Medicine, 2013 BACKGROUND Current therapies for pulmonary arterial hypertension have been adopted on the basis of short-term trials with exercise capacity as the primary end point. We assessed the efficacy of macitentan, a new dual endothelin-receptor antagonist, using
T. Pulido +18 more
semanticscholar +1 more source
Matrix metalloproteinase 7 in diagnosis and differentiation of pulmonary arterial hypertension
Pulmonary Circulation, 2019 Pulmonary arterial hypertension is a severe disease for which diagnosis often is delayed. Matrix metalloproteinases have been suggested to play a role in vascular remodeling and pulmonary hypertension development. Our aim was therefore to investigate the
Mattias Arvidsson +3 more
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Transcription factors and potential therapeutic targets for pulmonary hypertension
Frontiers in Cell and Developmental Biology, 2023 Pulmonary hypertension (PH) is a refractory and fatal disease characterized by excessive pulmonary arterial cell remodeling. Uncontrolled proliferation and hypertrophy of pulmonary arterial smooth muscle cells (PASMCs), dysfunction of pulmonary arterial ...
Liu Yang +5 more
doaj +1 more source
Anticoagulation in pulmonary arterial hypertension: a decision analysis
Pulmonary Circulation, 2019 Systemic anticoagulation may be beneficial in pulmonary arterial hypertension, but there is no randomized clinical trial data to guide therapeutic decision making, and current guidelines do not account for patient preferences or quality of life. Decision
Arun Jose +2 more
doaj +1 more source