Results 71 to 80 of about 445,623 (380)

Extracorporeal Catalytic Hemoperfusion Therapy for Refractory Septic Shock Using Ceria Nanoparticle‐Embedded Porous Microbeads

Advanced Functional Materials, EarlyView.
This study introduces an extracorporeal hemoperfusion system incorporating porous microbeads embedded with autocatalytic ceria nanoparticles (CeNPs) for targeted reactive oxygen species (ROS) scavenging in septic shock. The blood‐compatible hemoperfusion cartridge demonstrated significant improvements in survival, hemodynamic stability, and organ ...
Pilseon Im, Han‐Gil Jeong, Donghee Kim, Jimin Song, Ngoc Man Phan, Eun‐seo Choi, Young‐Min Kim, Seo‐Hyeon Jeong, Jooho Park, Inwon Park, Jaeyun Kim   +10 more
wiley   +1 more source

Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model

European Respiratory Journal, 2017
The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with pulmonary arterial hypertension (PAH).
M. Hoeper, T. Kramer, Z. Pan, C. Eichstaedt, J. Spiesshoefer, N. Benjamin, K. Olsson, K. Meyer, C. Vizza, A. Vonk-Noordegraaf, O. Distler, C. Opitz, J. Gibbs, M. Delcroix, H. Ghofrani, D. Huscher, D. Pittrow, S. Rosenkranz, E. Grünig   +18 more
semanticscholar   +1 more source

The Glycobiology of Pulmonary Arterial Hypertension

Metabolites, 2022
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease of complex etiology. Cases of PAH that do not receive therapy after diagnosis have a low survival rate. Multiple reports have shown that idiopathic PAH, or IPAH, is associated with metabolic dysregulation including altered bioavailability of nitric oxide (NO) and ...
Shia Vang, Phillip Cochran, Julio Sebastian Domingo, Stefanie Krick, Jarrod Wesley Barnes   +4 more
openaire   +3 more sources

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Metabolomics of exercise pulmonary hypertension are intermediate between controls and patients with pulmonary arterial hypertension

Pulmonary Circulation, 2019
Mechanisms underlying pulmonary arterial hypertension (PAH) remain elusive. Pulmonary arterial hypertension and exercise PH share similar physiologic consequences; it is debated whether they share biologic mechanisms and if exercise PH represents an ...
Jason L. Sanders, Yuchi Han, Mariana F. Urbina, David M. Systrom, Aaron B. Waxman   +4 more
doaj   +1 more source

Genetics and genomics of pulmonary arterial hypertension

European Respiratory Journal, 2019
Since 2000 there have been major advances in our understanding of the genetic and genomics of pulmonary arterial hypertension (PAH), although there remains much to discover. Based on existing knowledge, around 25–30% of patients diagnosed with idiopathic
N. Morrell, M. Aldred, W. Chung, C. G. Elliott, William C Nichols, F. Soubrier, R. Trembath, James E. Loyd   +7 more
semanticscholar   +1 more source

Treatments for pulmonary arterial hypertension [PDF]

Respiratory Medicine, 2006
Pulmonary arterial hypertension (PAH) is a devastating disease that leads to right heart failure and premature death. Historically, we are restricted by limited options for drug treatment. Over the past decade, with advances in our understanding of pathophysiological and molecular mechanisms, many new therapeutic strategies (synthetic prostacyclin and ...
Kunshen Liu, Chao Liu, Zhenguo Ji, Gang Liu   +3 more
openaire   +3 more sources

Non‐Invasive Diagnosis of Hypertrophic Cardiomyopathy by Breath

Advanced Sensor Research, EarlyView.
The use of sensor technologies for the diagnosis of hypertrophic cardiomyopathy (HCM) by identification of volatile organic compounds (VOCs) in breath samples. By combining gas chromatography‐mass spectrometry (GC‐MS) and electronic nose (eNose) platforms, specific VOC patterns associated with HCM are detected and analyzed.
Yael Hershkovitz‐Pollak, Manhal Habib, Yoav Y. Broza, Olga Katz, Harry Rakowski, Hossam Haick   +5 more
wiley   +1 more source

Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension

Pulmonary Circulation, 2020
We aimed to characterize the plasma metabolome of chronic thromboembolic pulmonary hypertension patients using a high-throughput unbiased omics approach.
Gustavo A. Heresi, Jacob T. Mey, John R. Bartholomew, Ihab S. Haddadin, Adriano R. Tonelli, Raed A. Dweik, John P. Kirwan, Satish C. Kalhan   +7 more
doaj   +1 more source

Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training

Frontiers in Physiology, 2023
Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial
Filipe Rios Drummond, Luciano Bernardes Leite, Denise Coutinho de Miranda, Denise Coutinho de Miranda, Lucas Rios Drummond, Victor Neiva Lavorato, Leôncio Lopes Soares, Clóvis Andrade Neves, Antônio José Natali   +8 more
doaj   +1 more source