Results 211 to 220 of about 208,145 (265)

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci, Carlotta Bidoli, Marco Gerdol, Charisse Winston, Robert A. Rissman, Giuliana Decorti, Antonella Fabretto, Andrea Taddio, Gabriele Stocco, Erik Roman‐Pognuz, Marianna Lucafò   +10 more
wiley   +1 more source

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function. [PDF]

Eur J Heart Fail
Ameri P, Mercurio V, Pollesello P, Anker MS, Backs J, Bayes-Genis A, Borlaug BA, Burkhoff D, Caravita S, Chan SY, de Man F, Giannakoulas G, González A, Guazzi M, Hassoun PM, Hemnes AR, Maack C, Madden B, Melenovsky V, Müller OJ, Papp Z, Pullamsetti SS, Rainer PP, Redfield MM, Rich S, Schiattarella GG, Skaara H, Stellos K, Tedford RJ, Thum T, Vachiery JL, van der Meer P, Van Linthout S, Pruszczyk P, Seferovic P, Coats AJS, Metra M, Rosano G, Rosenkranz S, Tocchetti CG.   +39 more
europepmc   +1 more source

Spotlight commentary: Drug therapy in hypoxic environments: From aerospace models to high‐altitude clinical pharmacology

British Journal of Clinical Pharmacology, EarlyView.
Martin Bobek, Jakov Kožić, Feđa Džubur   +2 more
wiley   +1 more source

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Pulmonary circulation

European Radiology, 1998
Evaluation of the pulmonary vasculature is mainly indicated in patients with suspected pulmonary thromboembolism. The routine procedure so far is ventilation-perfusion scintigraphy alone or in combination with diagnostic assessment of the legs to rule out deep venous thrombosis. The results are still not reliable for the majority of patients.
Bongartz, G., Boos, M., Scheffler, K., Steinbrich, W.   +3 more
openaire   +3 more sources

Pulmonary Circulation at Exercise

Comprehensive Physiology, 2012
Abstract The pulmonary circulation is a high‐flow and low‐pressure circuit, with an average resistance of 1 mmHg/min/L in young adults, increasing to 2.5 mmHg/min/L over four to six decades of life. Pulmonary vascular mechanics at exercise are best described by distensible models.
Naeije, Robert, Chesler, Naomi C
openaire   +3 more sources

STUDIES OF THE PULMONARY CIRCULATION [PDF]

Journal of Experimental Medicine, 1911
exaly   +3 more sources

The Pulmonary Circulation

JAMA: The Journal of the American Medical Association, 1978
THE HISTORY of the pulmonary circulation provides a measure of man's thinking about himself and his place in the universe. For centuries before De Motu Cordis in 1628, 1 the blood vessels of the lungs were incorporated into an elaborate scheme that explained the origin and distribution of spirits that animated and sustained the human being.
openaire   +2 more sources

Digitalis and the pulmonary circulation

American Heart Journal, 1961
Abstract In anesthetized dogs, the intravenous injection of acetyl strophanthidin caused a slight decrease in pulmonary arterial pressure which could not be explained by the effect on left atrial pressure. There was a marked decrease in the pulmonary venous flow, which was often accompanied by cardiac slowing and an increase in the calculated ...
Y S, KIM, D M, AVIADO
openaire   +2 more sources

Prostaglandins and the pulmonary circulation

Prostaglandins, 1973
Abstract Prostaglandins (PG) E 1 , E 2 , F 2 α , and A 1 were infused into 15 normal mongrel dogs at doses varying from .04 – 6.0 μg/kg/min. Pressures were recorded from the pulmonary artery, left atrium and femoral artery; pulmonary blood volume and cardiac output were determined using sequential indicator dilution curves from injections into the ...
J S, Alpert, F W, Haynes, P A, Knutson, J E, Dalen, L, Dexter   +4 more
openaire   +2 more sources

Pulmonary Circulation in Hypoxia

International Journal of Sports Medicine, 1992
Hypoxia constricts the pulmonary vessels. An increase in pulmonary vascular resistance is seen in normal subjects during hypoxic breathing at sea level, in acclimatized lowlanders and in high altitude natives. Hypoxic pulmonary hypertension in all these circumstances is most generally moderate, except in high altitude natives at exercise.
openaire   +3 more sources