Parameter inference in a computational model of hemodynamics in pulmonary hypertension [PDF]
Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) $>$ 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary arterial compliance. There are few measurable biomarkers of PH progression, but a conclusive diagnosis of the disease requires invasive right heart catheterization (RHC ...
arxiv
No previous meta-analysis has evaluated the efficacy and safety of pulmonary vasodilators in Fontan physiology. Recent relative trials have obtained conflicting results regarding improvements in peak oxygen consumption; the relatively small number of ...
Wuwan Wang+9 more
semanticscholar +1 more source
Stochastic Simulation of Human Pulmonary Blood Flow and Transit Time Frequency Distribution Based on Anatomic and Elasticity Data [PDF]
The objective of our study was to develop a computing program for computing the transit time frequency distributions of red blood cell in human pulmonary circulation, based on our anatomic and elasticity data of blood vessels in human lung.
Jun Shi, R. T. Yen, Wei Huang
core +2 more sources
Sex differences in the pulmonary circulation: implications for pulmonary hypertension.
Pulmonary arterial hypertension (PAH), a form of pulmonary hypertension, is a complex disease of multifactorial origin. While new developments regarding pathophysiological features and therapeutic options in PAH are being reported, one important fact has
Y. Martin, C. Pabelick
semanticscholar +1 more source
Use of a right ventricular continuous flow pump to validate the distensible model of the pulmonary vasculature [PDF]
In the pulmonary circulation, resistive and compliant properties overlap in the same vessels. Resistance varies nonlinearly with pressure and flow; this relationship is driven by the elastic properties of the vessels. Linehan et al. (1982) correlated the
Bové, Thierry+5 more
core +2 more sources
Fulvine and the pulmonary circulation [PDF]
The pyrrolizidine alkaloid, fulvine, is now accepted as a major cause of veno-occlusive disease of the liver in the West Indies, where it is ingested as a decoction of the plant Crotalaria fulva in bush tea. Fulvine is similar in chemical structure to monocrotaline, which is known to cause pulmonary hypertension in rats.
Paul Smith+4 more
openaire +3 more sources
Noninvasive Estimation of Mean Pulmonary Artery Pressure Using MRI, Computer Models, and Machine Learning [PDF]
Pulmonary Hypertension (PH) is a severe disease characterized by an elevated pulmonary artery pressure. The gold standard for PH diagnosis is measurement of mean Pulmonary Artery Pressure (mPAP) during an invasive Right Heart Catheterization. In this paper, we investigate noninvasive approach to PH detection utilizing Magnetic Resonance Imaging ...
arxiv
Reflex responses from the main pulmonary artery and bifurcation in anaesthetised dogs [PDF]
This study was undertaken to determine the reflex cardiovascular and respiratory responses to discrete stimulation of pulmonary arterial baroreceptors using a preparation in which secondary modulation of responses from other reflexes was prevented.
Drinkhill, M.J.+3 more
core +1 more source
Background: The elevated gamma-glutamyltransferase (GGT) activity is regarded as an indicator of cardiovascular disease, with males having higher values than females.
Gang-Hua Lu+9 more
doaj +1 more source
Efficient Uncertainty Quantification in a Multiscale Model of Pulmonary Arterial and Venous Hemodynamics [PDF]
Computational hemodynamics models are becoming increasingly useful in the management and prognosis of complex, multiscale pathologies, including those attributed to the development of pulmonary vascular disease. However, diseases like pulmonary hypertension are heterogeneous, and affect both the proximal arteries and veins as well as the ...
arxiv