Results 51 to 60 of about 11,770,891 (406)

Psychosocial Need Analysis of Patients with Pulmonary Tuberculosis. [PDF]

open access: yes, 2014
Pulmonary tuberculosis (TB) is a chronic pulmonary disease impacted on physical and psychosocial of the patients. However, to date, the goverment’s programs has not address the psychososial problem of the patients yet.
Hernawati, T. (Taty)   +3 more
core   +2 more sources

Cavitary Legionella Pneumonia in AIDS: When Intracellular Immunity Failure Leads to Rapid Intrapulmonary Cavitation

open access: yesCase Reports in Pulmonology, 2021
Introduction. Legionella is a frequent cause of bacterial pneumonia in patients with AIDS. While multiple organisms have been associated with cavitary pneumonia in this population, Legionella has not. Clinical Case.
Richard Jesse Durrance   +3 more
doaj   +1 more source

The patient experience of pulmonary hypertension: a large cross-sectional study of UK patients

open access: yesBMC Pulmonary Medicine, 2019
Background Pulmonary Hypertension Association UK (PHA-UK) is the only charity in the UK especially for people affected by pulmonary hypertension (PH).
Iain Armstrong   +6 more
doaj   +1 more source

Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models. [PDF]

open access: yes, 2016
Pulmonary hypertension (PH) is a complex disease comprising a pathologic remodeling and thickening of the pulmonary vessels causing an after load on the right heart ventricle that can result in ventricular failure. Triggered by oxidative stress, episodes
Ahmed, Mohamed   +5 more
core   +2 more sources

Chronic Thromboembolic Pulmonary Hypertension: A Review of the Multifaceted Pathobiology

open access: yesBiomedicines, 2023
Chronic thromboembolic pulmonary disease results from the incomplete resolution of thrombi, leading to fibrotic obstructions. These vascular obstructions and additional microvasculopathy may lead to chronic thromboembolic pulmonary hypertension (CTEPH ...
Hakim Ghani, Joanna Pepke-Zaba
doaj   +1 more source

Cellular senescence mediates fibrotic pulmonary disease

open access: yesNature Communications, 2017
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary ...
M. Schafer   +22 more
semanticscholar   +1 more source

Protein engineering to develop a redox insensitive endothelial nitric oxide synthase

open access: yesRedox Biology, 2014
The zinc tetrathiolate (ZnS4) cluster is an important structural feature of endothelial nitric oxide synthase (eNOS). The cluster is located on the dimeric interface and four cysteine residues (C94 and C99 from two adjacent subunits) form a cluster with ...
Ruslan Rafikov   +9 more
doaj   +1 more source

Higher circulating Trimethylamine N-oxide levels are associated with worse severity and prognosis in pulmonary hypertension: a cohort study

open access: yesRespiratory Research, 2022
Background Trimethylamine N-oxide (TMAO), the gut microbiota-dependent metabolite, is a potential biomarker in several cardiovascular diseases. However, no study has investigated its value in pulmonary hypertension (PH).
Yicheng Yang   +10 more
doaj   +1 more source

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

open access: yesNature Genetics, 2018
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are ...
N. Shrine   +108 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

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