Results 1 to 10 of about 386,415 (318)

Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis

Respiratory Research
Idiopathic pulmonary fibrosis (IPF) is a high-mortality lung disease with unclear pathogenesis. Convincing evidence suggests that an imbalance in mitochondrial homeostasis resulting from repeated injury to alveolar epithelial type 2 cells (AEC2 ...
Hui Lian, Kai Xu, Airu Chang, Yaxuan Wang, Shuaichen Ma, Lianhui Cheng, Wenyu Zhao, Cong Xia, Lan Wang, Guoying Yu   +9 more
doaj   +1 more source

Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis

Epigenetics & Chromatin
Background Pulmonary fibrosis is a relentless and ultimately fatal lung disorder. Despite a wealth of research, the intricate molecular pathways that contribute to the onset of PF, especially the aspects related to epigenetic modifications and chromatin ...
Zhongzheng Li, Mengke Zhang, Yujie Zhang, Yulong Gan, Zhao Zhu, Jiawei Wang, Yanlin Zhou, Guoying Yu, Lan Wang   +8 more
doaj   +1 more source

Quantum-inspired Minimum Distance Classification in Biomedical Context [PDF]

arXiv, 2018
We face the problem of pattern classification by proposing a quantum-inspired version of the widely used minimum distance classifier (i.e. the Nearest Mean Classifier (NMC)) already introduced in [31,33,28,27] and by applying this quantum-inspired classifier in a biomedical context.
arxiv  

TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA

Nature Communications
Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for ...
Xin Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O. Rosas, Guoying Yu   +16 more
doaj   +1 more source

A poroelastic model coupled to a fluid network with applications in lung modelling [PDF]

arXiv, 2014
Here we develop a lung ventilation model, based a continuum poroelastic representation of lung parenchyma and a 0D airway tree flow model. For the poroelastic approximation we design and implement a lowest order stabilised finite element method. This component is strongly coupled to the 0D airway tree model. The framework is applied to a realistic lung
arxiv  

Case Series: Hyperbilirubinemia under elexacaftor/tezacaftor/ivacaftor in the presence of Gilbert’s syndrome

BMC Pulmonary Medicine
Liver-related side effects are a known complication of treatment with elexacaftor/tezacaftor/ivacaftor (ETI) for cystic fibrosis (CF). Gilbert’s syndrome is caused by a genetic mutation that reduces activity of the enzyme UDP glucuronosyltransferase 1 ...
Julia Weitzel, Matthias Welsner, Christian Taube, Manfred Ballmann, Sivagurunathan Sutharsan   +4 more
doaj   +1 more source

Triiodothyronine acts on DAO to regulate pulmonary fibrosis progression by facilitating cell senescence through the p53/p21 signaling pathway

Frontiers in Pharmacology
BackgroundIdiopathic pulmonary fibrosis (IPF) is the result of multiple cycles of epithelial cell injury and fibroblast activation; currently, there is no clear etiology. Increasing evidence suggests that protein metabolism and amino acids play a crucial
Xiaoshu Guo, Xiaoshu Guo, Kai Xu, Lan Wang, Linke Ding, Wenwen Li, Xinsheng Zhang, Weiming Zhao, Ningdan Wang, Gaiping Wang, Wenyu Zhao, Ivan Rosas, Guoying Yu   +12 more
doaj   +1 more source

Assessing the impact of triiodothyronine treatment on the lung microbiome of mice with pulmonary fibrosis

BMC Pulmonary Medicine
Background Idiopathic pulmonary fibrosis (IPF), an interstitial lung disease, is characterized by the exacerbation of progressive pulmonary fibrosis (PF). IPF primarily affects older individuals and can lead to respiratory failure.
Xiaoshu Guo, Kai Xu, Qiwen Wang, Zongyuan Han, Guoying Yu   +4 more
doaj   +1 more source

The role of the cytoskeleton in fibrotic diseases

Frontiers in Cell and Developmental Biology
Fibrosis is the process whereby cells at a damaged site are transformed into fibrotic tissue, comprising fibroblasts and an extracellular matrix rich in collagen and fibronectin, following damage to organs or tissues that exceeds their repair capacity ...
Caoyuan Niu, Yanan Hu, Kai Xu, Xiaoyue Pan, Lan Wang, Guoying Yu   +5 more
doaj   +1 more source

Barriers to timely diagnosis of interstitial lung disease in the real world: the INTENSITY survey

BMC Pulmonary Medicine, 2018
Background The diagnosis of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILD) presents significant clinical challenges.
Gregory P. Cosgrove, Pauline Bianchi, Sherry Danese, David J. Lederer   +3 more
doaj   +1 more source