Results 1 to 10 of about 1,731,614 (343)

Genome-wide DNA methylation dynamics in carbon tetrachloride-induced mice liver fibrosis [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Many persistent harmful stimuli can result in chronic liver diseases, which lead to about 2 million deaths per year in the whole world. Liver fibrosis was found to exist in all kinds of chronic liver diseases.
Deming Li, Xiaoshu Guo, Wenyu Zhao, Jingyu Chen, Cong Xia, Guoying Yu   +5 more
doaj   +1 more source

Nos2 deficiency enhances carbon tetrachloride-induced liver injury in aged mice [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4).
Deming Li, Yaping Song, Yahao Wang, Yuedong Guo, Zhaoke Zhang, Ganggang Yang, Gaiping Wang, Cunshuan Xu   +7 more
doaj   +1 more source

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

American Journal of Respiratory and Critical Care Medicine, 2022
Background This American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior idiopathic pulmonary fibrosis (IPF) guidelines and addresses the progression of ...
G. Raghu, M. Rémy-Jardin, L. Richeldi, C. Thomson, Y. Inoue, T. Johkoh, M. Kreuter, D. Lynch, T. Maher, F. Martinez, M. Molina-Molina, J. Myers, A. Nicholson, C. Ryerson, M. Strek, L. Troy, M. Wijsenbeek, M. Mammen, Tanzib Hossain, B. Bissell, D. Herman, S. Hon, F. Kheir, Y. Khor, M. Macrea, K. Antoniou, Demosthenes Bouros, I. Buendía-Roldán, F. Caro, B. Crestani, L. Ho, J. Morisset, A. Olson, A. Podolanczuk, V. Poletti, M. Selman, Thomas J. Ewing, S. Jones, S. Knight, M. Ghazipura, K. Wilson   +40 more
semanticscholar   +1 more source

Global incidence and prevalence of idiopathic pulmonary fibrosis

Respiratory Research, 2021
Background Idiopathic pulmonary fibrosis (IPF) is a progressive debilitating lung disease with considerable morbidity. Heterogeneity in epidemiologic studies means the full impact of the disease is unclear.
T. Maher, E. Bendstrup, L. Dron, J. Langley, Gerald L. Smith, J. Khalid, H. Patel, M. Kreuter   +7 more
semanticscholar   +1 more source

Establishing CREATE: lessons learned in setting up a training environment for early-career researchers in respiratory medicine

BMC Medical Education, 2022
Background The purpose of the National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis (CRE-PF) is to improve and extend the lives of patients living with pulmonary fibrosis through the development of a ...
Katherine Christian, Alison Hey-Cunningham, Tamera Corte, Nicole Goh, Jade Jaffar, Paul Reynolds, Alan Teoh, Lauren Troy   +7 more
doaj   +1 more source

Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis

Frontiers in Pharmacology, 2022
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality. With an increase in life expectancy, the economic burden of IPF is
Qian Mei, Zhe Liu, He-Ning Zuo, Zhenhua Yang, Jing Qu   +4 more
semanticscholar   +1 more source

Idiopathic pulmonary fibrosis: Current and future treatment

Clinical Respiratory Journal, 2022
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease characterized by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and architecture is destroyed, compliance is lost, and gas exchange is compromised in this ...
Daniel S. Glass, D. Grossfeld, Heather A. Renna, Priya Agarwala, P. Spiegler, J. Deleon, A. Reiss   +6 more
semanticscholar   +1 more source

Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis

Scientific Reports, 2023
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease that causes irreversible damage to lung tissue characterized by excessive deposition of extracellular matrix (ECM) and remodeling of lung parenchyma.
Zhongzheng Li, Shenghui Wang, Huabin Zhao, Peishuo Yan, Hongmei Yuan, Mengxia Zhao, Ruyan Wan, Guoying Yu, Lan Wang   +8 more
doaj   +1 more source

Pulmonary Fibrosis as a Result of Acute Lung Inflammation: Molecular Mechanisms, Relevant In Vivo Models, Prognostic and Therapeutic Approaches

International Journal of Molecular Sciences, 2022
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung architecture disruption and respiratory failure. The development of pulmonary fibrosis is mostly the result of previous acute lung inflammation, caused by a wide variety
I. Savin, M. Zenkova, A. Sen’kova
semanticscholar   +1 more source

Immune dysregulation as a driver of idiopathic pulmonary fibrosis.

Journal of Clinical Investigation, 2021
Idiopathic pulmonary fibrosis (IPF) affects hundreds of thousands of people worldwide, reducing their quality of life and leading to death from respiratory failure within years of diagnosis.
K. Shenderov, S. Collins, J. Powell, M. Horton   +3 more
semanticscholar   +1 more source