Results 151 to 160 of about 412,177 (358)

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

RNA-seq reproducibility of Pseudomonas aeruginosa in laboratory models of cystic fibrosis

Microbiology Spectrum
Reproducibility is a fundamental expectation in science and enables investigators to have confidence in their research findings and the ability to compare data from disparate sources, but evaluating reproducibility can be elusive. For example, generating
Rebecca P. Duncan, Gina R. Lewin, Daniel M. Cornforth, Frances L. Diggle, Ananya Kapur, Dina A. Moustafa, Yasmin Hilliam, Jennifer M. Bomberger, Marvin Whiteley, Joanna B. Goldberg   +9 more
doaj   +1 more source

Bronchiolitis obliterans. [PDF]

, 1989
Bronchiolitis obliterans in the adult patient is a relatively uncommon and vexing clinical entity. This confusion results because this pathologic finding occurs in a variety of diverse clinical settings.
King, TE
core  

Integrin αvβ6‐Targeted PET/CT Imaging of Non‐Small Cell Lung Cancer with [68Ga]Ga‐Trivehexin: Improved Preoperative Lymph Node Staging and Association with Immunohistochemistry

Advanced Science, EarlyView.
Integrin αvβ6‐targeted [68Ga]Ga‐Trivehexin positron emission tomography/computed tomography (PET/CT) can accurately identify regional lymph nodes and cerebral metastases in non‐small cell lung cancer (NSCLC) compared with 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG).
Huiqin Wu, Chongjiao Li, Ling Li, Yueli Tian, Zhiwei Xiao, Yiwei Huang, Juan Zhong, Jianying Huang, Qiongrong Chen, Yong He   +9 more
wiley   +1 more source

Succinate promotes pulmonary fibrosis through GPR91 and predicts death in idiopathic pulmonary fibrosis

Scientific Reports
Idiopathic pulmonary fibrosis (IPF) is believed to be associated with a notable disruption of cellular energy metabolism. By detecting the changes of energy metabolites in the serum of patients with pulmonary fibrosis, we aimed to investigate the ...
Yijun He, Yuanyuan Han, Lijun Zou, Tingting Yao, Yan Zhang, Xin Lv, Mao Jiang, Lingzhi Long, Mengyu Li, Xiaoyun Cheng, Guoliang Jiang, Zhangzhe Peng, Lijian Tao, Jie Meng, Wei Xie   +14 more
doaj   +1 more source

An Immunohistological Evaluation of Pseudomonas aeruginosa Pulmonary Infection in Two Patients with Cystic Fibrosis [PDF]

, 1987
David P. Speert, James E. Dimmick, Gerald B. Pier, James M. Saunders, Robert E. W. Hancock, N M Kelly   +5 more
openalex   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Bronchoalveolar Lavage Lipids in Idiopathic Pulmonary Fibrosis [PDF]

, 1989
Robert B. Low
openalex   +1 more source

An Ultra‐Selective and Humidity‐Resistant Room‐Temperature‐Operated NO2 Sensor Based on Black TiO2

Advanced Science, EarlyView.
A room‐temperature‐operated NO2 sensor that achieves ultrahigh selectivity and humidity resistance is developed using black TiO2 for the first time in this work. A portable sensing equipment capable of recognizing NO2 from a mixed atmosphere with several common interfering gases and identifying real environmental differences is developed ...
Xuelan Cheng, Yizheng Liu, Wei Zhong, Shuai Li, Yan Li, Zixi Zhao, Chunlei Zhang, Jidong Shi, Hui Liu, Zonglong Zhu, Fang Xu   +10 more
wiley   +1 more source