Results 11 to 20 of about 1,677,383 (218)

Progressive pulmonary fibrosis: an expert group consensus statement

European Respiratory Journal, 2022
This expert group consensus statement emphasises the need for standardising the definition of progressive fibrosing interstitial lung diseases (F-ILDs), with an accurate initial diagnosis being of paramount importance in ensuring appropriate initial ...
S. Rajan, V. Cottin, R. Dhar, S. Danoff, K. Flaherty, K. Brown, A. Mohan, Elizabeth Renzoni, M. Mohan, Zarir F. Udwadia, Padmanabha D. Shenoy, D. Currow, Anand Devraj, B. Jankharia, R. Kulshrestha, S. Jones, C. Ravaglia, S. Quadrelli, R. Iyer, S. Dhooria, M. Kolb, A. Wells   +21 more
semanticscholar   +1 more source

Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration

Cell Communication and Signaling, 2023
Background Matrix metalloproteinases (MMPs) play important roles in remodeling the extracellular matrix and in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Weiming Zhao, Lan Wang, Juntang Yang, Xinyu Chen, Xiaoshu Guo, Kai Xu, Ningdan Wang, Wenyu Zhao, Cong Xia, Hui Lian, Ivan Rosas, Guoying Yu   +11 more
doaj   +1 more source

The effect of pollutant exposure on cough in progressive pulmonary fibrosis. [PDF]

IJTLD Open
Vander Linden H, Zanini U, Kalluri M, Cole J, Boulanger P, Feist M, Ferrara G.   +6 more
europepmc   +2 more sources

ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts

Cell Death Discovery, 2023
Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease with a poor prognosis and limited therapeutic options, which is characterized by aberrant myofibroblast activation and pathological remodeling of the extracellular matrix,
Ruyan Wan, Lan Wang, Yudi Duan, Miaomiao Zhu, Wenwen Li, Mengxia Zhao, Hongmei Yuan, Kai Xu, Zhongzheng Li, Xiao Zhang, Guoying Yu   +10 more
doaj   +1 more source

Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

Frontiers in Pharmacology, 2022
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis within the alveolar wall that are not due to infection or cancer ...
Cristina Estornut, J. Milara, María Amparo Bayarri, N. Belhadj, J. Cortijo   +4 more
semanticscholar   +1 more source

Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation

Cellular & Molecular Biology Letters, 2022
Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident transmembrane protein gene family, and were found to be involved in lipid droplet (LD) formation. Recently,
Gaiping Wang, Anqi Chen, Yu Wu, Danlin Wang, Cuifang Chang, Guoying Yu   +5 more
doaj   +1 more source

Advances in the management of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis

British medical journal, 2022
Similarly to idiopathic pulmonary fibrosis (IPF), other interstitial lung diseases can develop progressive pulmonary fibrosis (PPF) characterized by declining lung function, a poor response to immunomodulatory therapies, and early mortality.
Gabrielle Y. Liu, G. S. Budinger, J. Dematte   +2 more
semanticscholar   +1 more source

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

Science Advances, 2020
Human lung single-cell atlas reveals the complexity and diversity of aberrant cellular populations in pulmonary fibrosis. We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells
T. Adams, J. Schupp, S. Poli, Ehab A. Ayaub, N. Neumark, F. Ahangari, S. Chu, B. Raby, G. DeIuliis, Michael Januszyk, Qiaonan Duan, H. Arnett, Asim Siddiqui, G. Washko, R. Homer, Xiting Yan, I. Rosas, N. Kaminski   +17 more
semanticscholar   +1 more source

Immune dysregulation as a driver of idiopathic pulmonary fibrosis.

Journal of Clinical Investigation, 2021
Idiopathic pulmonary fibrosis (IPF) affects hundreds of thousands of people worldwide, reducing their quality of life and leading to death from respiratory failure within years of diagnosis.
K. Shenderov, S. Collins, J. Powell, M. Horton   +3 more
semanticscholar   +1 more source

Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis

Frontiers in Immunology, 2021
This mini-review summarizes the current evidence for the role of macrophage activation and polarization in inflammation and immune response pertinent to interstitial lung disease, specifically pulmonary fibrosis. In the fibrosing lung, the production and
A. Kishore, M. Petrek
semanticscholar   +1 more source