Results 11 to 20 of about 386,415 (318)

Genome-wide DNA methylation dynamics in carbon tetrachloride-induced mice liver fibrosis [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Many persistent harmful stimuli can result in chronic liver diseases, which lead to about 2 million deaths per year in the whole world. Liver fibrosis was found to exist in all kinds of chronic liver diseases.
Deming Li, Xiaoshu Guo, Wenyu Zhao, Jingyu Chen, Cong Xia, Guoying Yu   +5 more
doaj   +1 more source

Nos2 deficiency enhances carbon tetrachloride-induced liver injury in aged mice [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4).
Deming Li, Yaping Song, Yahao Wang, Yuedong Guo, Zhaoke Zhang, Ganggang Yang, Gaiping Wang, Cunshuan Xu   +7 more
doaj   +1 more source

Establishing CREATE: lessons learned in setting up a training environment for early-career researchers in respiratory medicine

BMC Medical Education, 2022
Background The purpose of the National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis (CRE-PF) is to improve and extend the lives of patients living with pulmonary fibrosis through the development of a ...
Katherine Christian, Alison Hey-Cunningham, Tamera Corte, Nicole Goh, Jade Jaffar, Paul Reynolds, Alan Teoh, Lauren Troy   +7 more
doaj   +1 more source

Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis

Scientific Reports, 2023
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease that causes irreversible damage to lung tissue characterized by excessive deposition of extracellular matrix (ECM) and remodeling of lung parenchyma.
Zhongzheng Li, Shenghui Wang, Huabin Zhao, Peishuo Yan, Hongmei Yuan, Mengxia Zhao, Ruyan Wan, Guoying Yu, Lan Wang   +8 more
doaj   +1 more source

Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration

Cell Communication and Signaling, 2023
Background Matrix metalloproteinases (MMPs) play important roles in remodeling the extracellular matrix and in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Weiming Zhao, Lan Wang, Juntang Yang, Xinyu Chen, Xiaoshu Guo, Kai Xu, Ningdan Wang, Wenyu Zhao, Cong Xia, Hui Lian, Ivan Rosas, Guoying Yu   +11 more
doaj   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation

Cellular & Molecular Biology Letters, 2022
Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident transmembrane protein gene family, and were found to be involved in lipid droplet (LD) formation. Recently,
Gaiping Wang, Anqi Chen, Yu Wu, Danlin Wang, Cuifang Chang, Guoying Yu   +5 more
doaj   +1 more source

ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts

Cell Death Discovery, 2023
Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease with a poor prognosis and limited therapeutic options, which is characterized by aberrant myofibroblast activation and pathological remodeling of the extracellular matrix,
Ruyan Wan, Lan Wang, Yudi Duan, Miaomiao Zhu, Wenwen Li, Mengxia Zhao, Hongmei Yuan, Kai Xu, Zhongzheng Li, Xiao Zhang, Guoying Yu   +10 more
doaj   +1 more source

Fibro-CoSANet: Pulmonary Fibrosis Prognosis Prediction using a Convolutional Self Attention Network [PDF]

, 2021
Idiopathic pulmonary fibrosis (IPF) is a restrictive interstitial lung disease that causes lung function decline by lung tissue scarring. Although lung function decline is assessed by the forced vital capacity (FVC), determining the accurate progression of IPF remains a challenge. To address this challenge, we proposed Fibro-CoSANet, a novel end-to-end
arxiv   +1 more source

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Adamson IY, Artinian V, Aubry MC, Bai JW, Baumgartner KB, Berschneider B, Brody AR, Chen PP, Chilosi M, Chilosi M, Coalson JJ, Corrin B, Dasari V, Dissanayake SK, Dobbs LG, Flozak AS, Fukuda Y, Ha HY, Haddad R, Herzog EL, Hironaka M, Hu J, Huang CL, Hubbard R, Huber MA, Jayachandran A, Kasai H, Kasper M, Kato N, Kawasaki H, Kawasaki H, Kim J, Kim K, Kim KK, Kuwano K, Königshoff M, Königshoff M, Königshoff M, Lee JM, Liu L, Maher TM, Margalit O, Mason RJ, Matthay MA, Mazieres J, Melanie Königshoff, Moon RT, Nagai A, Pan LH, Park J, Pennison M, Plataki M, Qunn L, Radisky DC, Rosas IO, Sato M, Selman M, Selman M, Soon LL, Sternlicht MD, Thannickal VJ, Thiery JP, Uematsu K, Willis BC, Willis BC, Willis BC, Zavadil J   +66 more
core   +1 more source