Results 41 to 50 of about 1,677,383 (218)

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

Cellular and Molecular Life Sciences, 2020
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast areas of the lungs.
T. Phan, P. Paliogiannis, Gheyath K Nasrallah, Roberta Giordo, A. Eid, A. Fois, A. Zinellu, A. Mangoni, G. Pintus   +8 more
semanticscholar   +1 more source

Validation of gene editing efficiency with CRISPR-Cas9 system directly in rat zygotes using electroporation mediated delivery and embryo culture

MethodsX, 2021
Successful use of the CRISPR-Cas9 system for gene manipulation relies on identifying effective and efficient guide RNA sequences (gRNAs). When the goal is to create transgenic animal/rodent models by knocking-in desired sequences using homology-directed ...
Anil K. Challa, Denise Stanford, Antonio Allen, Lawrence Rasmussen, Ferdinand K. Amanor, S. Vamsee Raju   +5 more
doaj   +1 more source

The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT

PLoS ONE, 2021
The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately studied. AI-assisted chest high-resolution computed tomography (HRCT) was used to investigate the proportion of COVID-19
Jia-Ni Zou, Liu Sun, Bin-Ru Wang, Y. Zou, Shan Xu, Yongjun Ding, L. Shen, Wencai Huang, Xiao-Jing Jiang, Shi-Ming Chen   +9 more
semanticscholar   +1 more source

Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia

Frontiers in Immunology, 2023
IntroductionAcute myeloid leukemia (AML) is a type of blood cancer that is identified by the unrestricted growth of immature myeloid cells within the bone marrow. Despite therapeutic advances, AML prognosis remains highly variable, and there is a lack of
Zhongzheng Li, Xin Liu, Lan Wang, Huabin Zhao, Shenghui Wang, Guoying Yu, Depei Wu, Jianhong Chu, Jingjing Han   +8 more
doaj   +1 more source

Effects of Systemic Enzyme Supplements on Symptoms and Quality of Life in Patients with Pulmonary Fibrosis—A Pilot Study

Medicines, 2021
Current FDA-approved antifibrotic treatments for Idiopathic Pulmonary Fibrosis slow down disease progression but have little impact on symptoms or quality of life in patients.
Neha Shah
doaj   +1 more source

The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis

Journal of molecular medicine, 2021
Pulmonary fibrosis is a chronic debilitating condition characterized by progressive deposition of connective tissue, leading to a steady restriction of lung elasticity, a decline in lung function, and a median survival of 4.5 years. The leading causes of
Siavash Bolourani, M. Brenner, Ping Wang
semanticscholar   +1 more source

How personality influences health outcomes and quality of life in adult patients with cystic fibrosis

BMC Pulmonary Medicine, 2023
Background The present study evaluates personality traits in adult patients with cystic fibrosis (CF) and correlates these results with health-related quality of life (HRQoL) and other clinical parameters indicative of disease severity.
Ute Niehammer, Svenja Straßburg, Sivagurunathan Sutharsan, Christian Taube, Matthias Welsner, Florian Stehling, Raphael Hirtz   +6 more
doaj   +1 more source

Recovering from a pandemic: pulmonary fibrosis after SARS-CoV-2 infection

European Respiratory Review, 2021
Acute manifestations of SARS-CoV-2 infection continue to impact the lives of many across the world. Post-acute sequelae of coronavirus disease 2019 (COVID-19) may affect 10–30% of survivors of COVID-19, and post-acute sequelae of COVID-19 (PASC ...
Ruben J. Mylvaganam, J. Bailey, J. Sznajder, M. Sala   +3 more
semanticscholar   +1 more source

Prediction of the Development of Pulmonary Fibrosis Using Serial Thin-Section CT and Clinical Features in Patients Discharged after Treatment for COVID-19 Pneumonia

Korean Journal of Radiology, 2020
Objective To identify predictors of pulmonary fibrosis development by combining follow-up thin-section CT findings and clinical features in patients discharged after treatment for COVID-19.
Minhua Yu, Y. Liu, Dan Xu, Rongguo Zhang, Lan Lan, Haibo Xu   +5 more
semanticscholar   +1 more source

Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

Respiratory Research
Background Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased lipid content in the pathogenesis
Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu   +8 more
doaj   +1 more source