Results 101 to 110 of about 674,291 (325)

Parameter Inference in the Pulmonary Circulation of Mice [PDF]

, 2017
This study focuses on parameter inference in a pulmonary blood cir- culation model for mice. It utilises a fluid dynamics network model that takes selected parameter values and aims to mimic features of the pulmonary haemody- namics under normal ...
Colebank, Mitchel, Haider, Mansoor A., Hill, Nicholas A., Husmeier, Dirk, Olufsen, Mette S., Paun, L. Mihaela, Qureshi, M. Umar   +6 more
core  

CT-measured pulmonary artery diameter as an independent predictor of pulmonary hypertension in cystic fibrosis [PDF]

, 2018
Purpose: The role of computed tomography (CT) scan, as a promising prognostic imaging modality in cystic fibrosis(CF), has been widely investigated, focusing on parenchymal abnormalities.
Aghahosseini, Farahnaz, Bakhshayeshkaram, Mehrdad, Hassanzad, Maryam, Jamaati, Hamid Reza, Kahkooei, Shahram, Salehi, Yalda, Vaezi, Fatemeh, Velayati, Ali Akbar   +7 more
core   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Exploring the Endothelin-1 pathway in chronic thromboembolic pulmonary hypertension microvasculopathy

Scientific Reports
Targeted vasopeptide therapies have significantly advanced the management of pulmonary arterial hypertension (PAH). However, due to insufficient preclinical evidence regarding the involvement of the endothelin-1 (ET-1) pathway in chronic thromboembolic ...
Benchenouf Feriel, Cuomo Alessandra, Gorth J. Deborah, Normand Corinne, Thuillet Raphaël, Ottaviani Mina, Akamkam Ali, Menager Jean-Baptiste, Fadel Guillaume, Grynblat Julien, Ghigna Maria-Rosa, Fadel Elie, Savale Laurent, Mercier Olaf, Tu Ly, Humbert Marc, Guignabert Christophe   +16 more
doaj   +1 more source

DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells

Physiological Reports, 2019
Nitric Oxide (NO) is an endogenous pulmonary vasodilator produced by endothelial NO synthase (eNOS). Asymmetric dimethyl L‐arginine (ADMA) is an endogenous inhibitor of eNOS activity.
Jennifer K. Trittmann, Hanadi Almazroue, Yi Jin, Leif D. Nelin   +3 more
doaj   +1 more source

Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension. [PDF]

, 2016
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary vascular resistance (PVR) leading to right heart failure and premature death.
Ayako Makino, Haiyang Tang, Jason X.-J. Yuan, Jason X.-J. Yuan, Kimberly A. Smith, Ramon J. Ayon   +5 more
core   +3 more sources

Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During Pulmonary Hypertension

Advanced Science, EarlyView.
This study investigates the critical mechanisms underlying pulmonary hypertension progression, with a focus on the novel role of neutrophil‐derived S100A9 in endothelial dysfunction‐mediated pulmonary vascular remodeling. By integrating human lung samples, multi‐omics analyses, animal models, and mechanistic in vitro studies, it is revealed that how ...
Yu Guo, Zhenqiang Gao, Ruoyang Zhang, Huanyu Long, Muzhi Zhang, Lin Liu, Zhe An, Yuezhe Shi, Ye Cui, Yufeng Jia, Lei Wang, Ying Sun, Jie Liu, Wei Wang   +13 more
wiley   +1 more source

Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology

International Journal of Cardiology Congenital Heart Disease, 2022
Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the ...
Chinthaka B. Samaranayake, Ruth McNiven, Aleksander Kempny, Carl Harries, Laura C. Price, Michael Gatzoulis, Konstantinos Dimopoulos, Stephen J. Wort, Colm McCabe   +8 more
doaj  

Patient engagement and self-management in pulmonary arterial hypertension

European Respiratory Review, 2016
Improved care in pulmonary arterial hypertension has led to increased longevity for patients, with a paralleled evolution in the nature of their needs.
Jytte Graarup, Pisana Ferrari, Luke S. Howard   +2 more
doaj   +1 more source

The molecular genetics and cellular mechanisms underlying pulmonary arterial hypertension [PDF]

, 2012
Pulmonary arterial hypertension (PAH) is an incurable disorder clinically characterised by a sustained elevation of mean arterial pressure in the absence of systemic involvement.
Machado, Rajiv
core   +2 more sources