Results 91 to 100 of about 581,169 (264)

Dynamic immune signatures of patients with advanced non–small-cell lung cancer for infection prediction after immunotherapy

Frontiers in Immunology
BackgroundPulmonary infections are a crucial health concern for patients with advanced non–small-cell lung cancer (NSCLC). Whether the clinical outcome of pulmonary infection is influenced by immunotherapy(IO) remains unclear.
Yung-Hung Luo, Yung-Hung Luo, Chia-I Shen, Chia-I Shen, Chia-I Shen, Chi-Lu Chiang, Chi-Lu Chiang, Chi-Lu Chiang, Hsu-Ching Huang, Hsu-Ching Huang, Yuh-Min Chen, Yuh-Min Chen   +11 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Hard‐Magnetic Soft Millirobots in Underactuated Systems

Advanced Robotics Research, EarlyView.
This review provides a comprehensive overview of hard‐magnetic soft millirobots in underactuated systems. It examines key advances in structural design, physics‐informed modeling, and control strategies, while highlighting the interplay among these domains.
Qiong Wang, Zixuan Zhang, Bingyan Li, Junkai Wang, Hongcheng Gu   +4 more
wiley   +1 more source

Effects of bronchoscopic alveolar lavage–assisted mechanical ventilation on postoperative pulmonary infection and inflammatory factors in patients undergoing lung cancer surgery

Videosurgery and Other Miniinvasive Techniques
Introduction: Patients undergoing lung cancer (LC) surgery often develop pulmonary infection (PI) due to poor sputum excretion ability leading to accumulation of secretions. Bronchoalveolar lavage (BAL) during fiberoptic bronchoscopy can be used to clear
Hui Zhu, Haiyang Lu
doaj   +1 more source

Pulmonary Infection

, 2017
Virtually all infections that affect man can manifest within the lung. Pulmonary infection is the leading cause of death worldwide. The approach to the diagnosis and treatment of pulmonary infection requires a sound knowledge of both the microbial pathogens but also how the host immune system responds to infection.
openaire   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Rapid diagnosis of alveolar echinococcosis from lung puncture sample using metagenomic next-generation sequencing: a case report

BMC Infectious Diseases
Introduction Alveolar echinococcosis (AE), caused by the larval forms of Echinococcus multilocularis, is a zoonotic disease affecting the liver, lungs, lymph nodes, kidneys, brain, bones, thyroid, and other organs.
Chuanlin Zhou, Chunhong Li, Zhenfeng Deng, Xuexin Yan, Li Feng, Zhen Yang, Yanyan Lu, Yinglong Shi, Ke Wang, Jing Luo, Jinliang Kong   +10 more
doaj   +1 more source

Application of targeted next-generation sequencing for pathogens diagnosis and drug resistance prediction in bronchoalveolar lavage fluid of pulmonary infections

Frontiers in Cellular and Infection Microbiology
BackgroundRecently, targeted next-generation sequencing (tNGS) have been extensively utilized for the identification of pathogens in pulmonary infections, there have been some studies systematically evaluating differences in the efficacy of tNGS and ...
Qiugui Xu, Qiumei Chen, Wen Qiu, Lili Liu, Wan Zeng, Jinling Chen, Yangyang Li, Zhen Guo, Ling Rong, Bigui Chen, Jinxiu Yao, Liye Yang   +11 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source