Results 61 to 70 of about 963,916 (300)

Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry [PDF]

, 2020
OBJECTIVE: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension following Phase ...
Ulrich, Silvia, Helmersen, Douglas S, Giannakoulas, George, Snijder, Repke J, Simonneau, Gerald, Mielniczuk, Lisa M., Lange, Tobias J, Boonstra, Anco, Hoeper, Marius M., Pittrow, David, Mielniczuk, Lisa M, Mielniczuk, L., Simonneau, G. rald, Gall, Henning, Humbert, Marc, Langleben, David, Lange, Tobias Johannes, Pepke-Zaba, Joanna, Barberà i Mir, Joan Albert, Gomez Sanchez, Miguel-Angel, Halank, Michael, Klotsche, Jens, Jansa, Pavel, Snijder, Repke J., imková, Iveta, Rosenkranz, Stephan, Wirtz, Hubert, Escribano Subias, Pilar, Hoeper, Marius M, Gómez Sánchez, Miguel A., Barberà, Joan Albert, Grünig, Ekkehard, Gomez Sanchez, Miguel Angel, Ghofrani, Hossein-Ardeschir, Helmersen, Doug D.S., Meier, Christian, Simkova, Iveta, Vachiery, Jean-Luc, Williams, Evgenia, Barberà, Joan A, Ghofrani, Hossein Ardeschir, Collaborators list, Snijder, Repke R.J., Gruenig, Ekkehard, Klose, Hans, Subias, Pilar Escribano, Delcroix, Marion, Steringer-Mascherbauer, Regina, Barbera, Joan A., Tsangaris, Iraklis, Helmersen, Douglas S., Halank, M., Lange, Tobias J.   +52 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)

Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular ...
Forbes, Lindsay M, Stewart, Duncan J, Goss, Kara N, Zimmer, Alexsandra, Hemnes, Anna R., Leopold, Jane A, Bauer, Natalie, Hemnes, Anna R, Lahm, Tim, Oliveira, Suellen D., Rhodes, Christopher J., Klouda, Timothy, Oliveira, Suellen D, Prisco, Sasha Z, Bogaard, Harm J., Jose, Arun, Leopold, Jane A., Bhadra, Aritra, Hopper, Rachel K, Heresi, Gustavo A, Vanderpool, Rebecca R., Bogaard, Harm J, de Jesus Perez, Vinicio A, Kim, Yunhye, Stewart, Duncan J., Gräf, Stefan, Prisco, Sasha Z., Choudhary, Gaurav, Leary, Peter J., Forbes, Lindsay M., Goss, Kara N., Hopper, Rachel K., Rafikov, Ruslan, Wilkins, Martin R., Rhodes, Christopher J, Vanderpool, Rebecca R, Heresi, Gustavo A., Lawrie, Allan, Wilkins, Martin R, Yuan, Ke, Leary, Peter J, de Jesus Perez, Vinicio A.   +41 more
core   +1 more source

[Pulmonary nuclear medicine].

Kaku igaku. The Japanese journal of nuclear medicine, 1995
Pulmonary nuclear medicine dates back to Knipping and West in the late 1950's but practically starts with the successful production of 131I-MAA by GV Taplin in 1963. Not only is the diagnosis of pulmonary embolism greatly facilitated by using 131I-MAA but also studies of regional lung function have made rapid progress.
openaire   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: An Immunological Perspective

, 2020
Pulmonary hypertension (PH) is a debilitating progressive disease characterized by increased pulmonary arterial pressures, leading to right ventricular (RV) failure, heart failure and, eventually, death.
Koudstaal, Thomas, Mirjam Kool, Boomars, Karin, Karin A. Boomars, Thomas Koudstaal, Kool, Mirjam   +5 more
core   +1 more source