Respirable antisense oligonucleotides: a new drug class for respiratory disease
Respiratory Research, 2000 Respirable antisense oligonucleotides (RASONs), which attenuate specific disease-associated mRNAs, represent a new class of respiratory therapeutics with considerable potential.
Tanaka Makoto, Nyce Jonathan W
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Inflammatory Response as a Mechanism of Perinatal Programming: Long-term Impact on Pulmonary and Renal Function? [PDF]
, 2012 RATIONALE: Temporal changes in the fetal environment, such as malnutrition and placental insufficiency induce intrauterine growth restriction (IUGR) and lead to a permanent changes of physiological processes later in life.
Alejandre Alcázar, Miguel Angel
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Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs with meconium aspiration. [PDF]
, 2015 BackgroundCurrent neonatal resuscitation guidelines recommend tracheal suctioning of nonvigorous neonates born through meconium-stained amniotic fluid.MethodsWe evaluated the effect of tracheal suctioning at birth in 29 lambs with asphyxia induced by ...
Gugino, Sylvia F +7 more
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Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS).
PLoS ONE, 2014 The hepatopulmonary syndrome (HPS) develops when pulmonary vasodilatation leads to abnormal gas exchange. However, in human HPS, restrictive ventilatory defects are also observed supporting that the alveolar epithelial compartment may also be affected ...
Wenli Yang +7 more
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MedicinaRecent advances in genetics and epigenetics have provided critical insights into the pathogenesis of both idiopathic and non-idiopathic interstitial lung diseases (ILDs).
Stefania Cerri +12 more
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Proteomic Associations of Adverse Outcomes in Human Heart Failure
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Identifying novel molecular drivers of disease progression in heart failure (HF) is a high‐priority goal that may provide new therapeutic targets to improve patient outcomes.
Marie‐Joe Dib +29 more
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The pulmonary surfactant system matures upon pipping in the freshwater turtle Chelydra serpentina [PDF]
, 2002 © The Company of BiologistsPulmonary surfactant (PS), a mixture of phospholipids (PL), neutral lipids and surfactant proteins (SP), lowers surface tension within the lung, which increases lung compliance and improves the removal of fluid at birth.
Cenzato, David +4 more
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Journal of Lipid ResearchOxidized phospholipids (OxPLs) are increasingly recognized as toxic and proinflammatory mediators, which raises interest in the mechanisms of their detoxification.
Philipp Jokesch +7 more
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Gene expression profiling: can we identify the right target genes?
European Respiratory Review, 2008 Gene expression profiling allows the simultaneous monitoring of the transcriptional behaviour of thousands of genes, which may potentially be involved in disease development.
J. E. Loyd
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Lipid Metabolism and Obesity in Early Life: Drivers of Chronic Lung Disease From Development to Adulthood. [PDF]
Mol Nutr Food ResSelle J +8 more
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