Results 41 to 50 of about 73,571 (236)

Patterns of recruitment and injury in a heterogeneous airway network model [PDF]

, 2015
In respiratory distress, lung airways become flooded with liquid and may collapse due to surface-tension forces acting on air-liquid interfaces, inhibiting gas exchange.
Cressoni M, Murphy SL, Oliver E. Jensen, Peter S. Stewart, The Acute Respiratory Distress Syndrome Network, Weibel ER   +5 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The role of miR-431-5p in regulating pulmonary surfactant expression in vitro

Cellular & Molecular Biology Letters, 2019
Background Pulmonary surfactant is the complex mixture of lipid and protein that covers the alveolar surface. Pulmonary surfactant deficiency is one of the main causes of neonatal respiratory distress.
Shujun Li, Zhongyi Sun, Tao Chen, Jingjing Pan, Yanqing Shen, Xiaoqing Chen, Xiaoyu Zhou, Rui Cheng, Yang Yang   +8 more
doaj   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

CFD Study of Dry Pulmonary Surfactant Aerosols Deposition in Upper 17 Generations of Human Respiratory Tract

Atmosphere, 2022
The efficient generation of high concentrations of fine-particle, pure surfactant aerosols provides the possibility of new, rapid, and effective treatment modalities for Acute Respiratory Distress Syndrome (ARDS). SUPRAER-CATM is a patented technology by
Tevfik Gemci, Valery Ponyavin, Richard Collins, Timothy E. Corcoran, Suvash C. Saha, Mohammad S. Islam   +5 more
doaj   +1 more source

Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials. [PDF]

, 2014
BackgroundInhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants.
Ambalavanan, Namasivayam, Bara, Rebecca, Cotten, C Michael, Das, Abhik, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Garg, Meena, Higgins, Rosemary D, Keszler, Martin, Klein, Jonathan M, Lakshminrusimha, Satyan, Malian, Monica, Nelin, Leif D, Ohls, Robin, Saha, Shampa, Sanchez, Pablo J, Shankaran, Seetha, Sood, Beena G, Van Meurs, Krisa P, Wallace, Dennis   +18 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A case of uncomplicated pulmonary alveolar proteinosis evolving to pulmonary fibrosis

Monaldi Archives for Chest Disease, 2016
Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterised by intra-alveolar accumulation of surfactant components and cellular debris, with minimal interstitial inflammation or fibrosis.
A. Chroneou, N. Zias, B.S. Tronic, A.V. Gonzalez, J.F. Beamis Jr.   +4 more
doaj   +1 more source

Sequencing of idiopathic pulmonary fibrosis-related genes reveals independent single gene associations [PDF]

, 2014
BACKGROUND: Previous studies investigating a genetic basis for idiopathic pulmonary fibrosis (IPF) have focused on resequencing single genes in IPF kindreds or cohorts to determine the genetic contributions to IPF.
Coghlan, Meghan A, Cole, F. Sessions, Hamvas, Aaron, Huang, Howard J, Mitra, Robi D, Russell, Tonya D, Shifren, Adrian, Wegner, Daniel J, Zhang, Qunyuan   +8 more
core   +3 more sources