Results 91 to 100 of about 592,819 (238)

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +1 more source

Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy [PDF]

, 2017
Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite promoting vasodilation, current drugs have a therapeutic window within which they are limited by systemic side effects.
Lickiss, PD, Barreira, B, Mitchell, JA, Kirkby, NS, Reed, DM, Ahmetaj-Shala, B, Freeman, GR, Yacoub, MH, Mohamed, NA, Morales-Cano, D, Chester, AH, Saleem, H, Tetley, TD, Gashaw, HH, Moreno, L, Davies, RP, Wort, SJ, George, PM   +17 more
core   +1 more source

Morphometric analysis of postnatal lung development in the gray short‐tailed opossum (Monodelphis domestica): An ultrastructural study

The Anatomical Record, EarlyView.
Abstract An ultrastructural morphometric analysis of the postnatal development of the lung in the gray short‐tailed opossum (Monodelphis domestica) has been conducted to evaluate the morphofunctional status of this poorly developed marsupial lung immediately following parturition.
Kirsten Ferner
wiley   +1 more source

Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. [PDF]

, 2005
BACKGROUND: Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur.
Shakur, B Haleema, Paul J Robinson, Morrell, Nicholas W, Peter G Phillips, Shakur B Haleema, Matthew A Higham, B Haleema Shakur, Robinson Paul J, Nicholas W Morrell, Ray J Beddoes, Robinson, Paul J, Beddoes, Ray J, Beddoes Ray J, Higham, Matthew A, Phillips Peter G, Phillips, Peter G, Higham Matthew A, Morrell Nicholas W   +17 more
core   +2 more sources

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Lung molecular and histological changes in type 2 diabetic rats and its improvement by high-intensity interval training

BMC Pulmonary Medicine
Background Type 2 diabetes (T2D) leads to serious respiratory problems. This study investigated the effectiveness of high-intensity interval training (HIIT) on T2D-induced lung injuries at histopathological and molecular levels.
Mohammad Amin Rajizadeh, Kayvan Khoramipour, Siyavash Joukar, Fatemeh Darvishzadeh-Mahani, Maryam Iranpour, Mohammad Abbas Bejeshk, Maryam Doustaki Zaboli   +6 more
doaj   +1 more source

Non-Invasive Pulmonary Artery Wave Intensity Analysis in Pulmonary Hypertension. [PDF]

, 2015
Pulmonary wave reflections are a potential hemodynamic biomarker for pulmonary hypertension (PH) and can be analyzed using wave intensity analysis (WIA). In this study we used pulmonary vessel area and flow obtained using cardiac magnetic resonance (CMR)
Moledina, S, Coghlan, JG, Quail, MA, Knight, DS, Quail, Michael A, Muthurangu, Vivek, Taylor, Andrew M, Steeden, Jennifer A, Taelman, Liesbeth, Moledina, Shahin, Segers, P, Knight, Daniel S, Taylor, AM, Steeden, JA, Taelman, L, Segers, Patrick, Coghlan, J Gerry, Muthurangu, V   +17 more
core   +1 more source

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

Arthritis &Rheumatology, EarlyView.
Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D. Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Cleavable Surfactants: A Comparison between Ester, Amide, and Carbonate as the Weak Bond

, 2019
Cleavable surfactants, i.e., surfactants in which a weak bond has deliberately been inserted into the molecule, are of interest when remaining surface-active material at a surface can cause problems. Ester and amide bonds are established as week linkages
Lundberg, Dan,, Bordes, Romain,, Stjerndahl, Maria, Bordes, Romain, Romain Bordes, Dan Lundberg, Maria Stjerndahl, Holmberg, Krister,, Vinay Chauhan, Krister Holmberg, Holmberg, Krister, Chauhan, Vinay, Stjerndahl, Maria,, Chauhan, Vinay,, Lundberg, Dan   +14 more
core   +1 more source