Results 81 to 90 of about 23,810 (346)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Aerosol delivery of dry powder synthetic lung surfactant to surfactant-deficient rabbits and preterm lambs on non-invasive respiratory support [version 1; referees: 3 approved]

Gates Open Research, 2019
Background: The development of synthetic lung surfactant for preterm infants has focused on peptide analogues of native surfactant proteins B and C (SP-B and SP-C).
Frans J. Walther, Monik Gupta, Michael M. Lipp, Holly Chan, John Krzewick, Larry M. Gordon, Alan J. Waring   +6 more
doaj   +1 more source

A highly accurate boundary integral equation method for surfactant-laden drops in 3D

, 2017
The presence of surfactants alters the dynamics of viscous drops immersed in an ambient viscous fluid. This is specifically true at small scales, such as in applications of droplet based microfluidics, where the interface dynamics become of increased ...
Sorgentone, Chiara, Tornberg, Anna-Karin
core   +1 more source

The impact of cigarette/e-cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions [PDF]

, 2017
Deviation in pulmonary surfactant structure–function activity can impair airway patency and lead to respiratory disorders. This novel study aims to evaluate the influence cigarette/e-cigarette vapour has on model surfactant films located within a ...
Akbaş, Akella, Alonso, Anand, Behroozi, Bringezu, Brown, Chan-Yeung, Davies, Davies, Davies, Devendra, Ding, Farsalinos, Goniewicz, Hecht, Hua, Kandyala, Keating, Khattari, Kosmider, Lotze, Lusuardi, Lyklema, Nahak, Notter, Parra, Rodríguez-Capote, Saffari, Schripp, Scott, Shah, Soto-Arriaza, Stenger, Subramaniam, Tayyarah, Trehy, Uchiyama, Vijayaraj, Von Nahmen, Wang, Ward, Zasadzinski, Zetterberg   +43 more
core   +3 more sources

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

A multicenter, randomized, double-blind trial of a new porcine surfactant in premature infants with respiratory distress syndrome

Einstein (São Paulo)
Objective To compare the efficacy and safety of a new porcine-derived pulmonary surfactant developed by Instituto Butantan with those of animal-derived surfactants commercially available in Brazil, regarding neonatal mortality and the major complications
Celso Moura Rebello, Alexander Roberto Precioso, Renata Suman Mascaretti   +2 more
doaj   +1 more source

Aerosol delivery of dry powder synthetic lung surfactant to surfactant-deficient rabbits and preterm lambs on non-invasive respiratory support [version 2; referees: 3 approved]

Gates Open Research, 2019
Background: The development of synthetic lung surfactant for preterm infants has focused on peptide analogues of native surfactant proteins B and C (SP-B and SP-C).
Frans J. Walther, Monik Gupta, Michael M. Lipp, Holly Chan, John Krzewick, Larry M. Gordon, Alan J. Waring   +6 more
doaj   +1 more source

Gas-liquid hydrodynamics in Taylor Flows with complex liquids [PDF]

, 2010
Universitá di Pisa Facoltá di Ingegneria Dipartimento di Ingegneria Chimica, Chimica Industriale e Scienza dei Materiali Relazione di tirocinio in Ingegneria Chimica Gas-liquid hydrodynamics in Taylor Flows with complex liquids Il candidato: Federico ...
ALBERINI, FEDERICO
core  

Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery [PDF]

, 2014
Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics.
Conway, Barbara R, Kakadia, Pratibha G.
core   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source