Results 81 to 90 of about 592,819 (238)

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

The effect of a peptide-containing synthetic lung surfactant on gas exchange and lung mechanics in a rabbit model of surfactant depletion

Drug Design, Development and Therapy, 2013
Johann M van Zyl,1 Johan Smith,2 Arthur Hawtrey1 1Division of Pharmacology, 2Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa Background: Currently, a new generation of synthetic pulmonary surfactants is being ...
van Zyl JM, Smith J, Hawtrey A
doaj  

Isolated right pulmonary artery discontinuity [PDF]

, 2000
Unilateral “absence” of the pulmonary artery is an uncommon malformation frequently associated with congenital heart disease. In fact, the pulmonary artery is typically discontinuous from the main pulmonary artery, not absent.
Vincent, J.A., Epstein, M.L., Turner, Daniel   +2 more
core  

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Königshoff, M., Melanie Königshoff, Königshoff, Melanie   +2 more
core   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Intravenous iron therapy in patients with idiopathic pulmonary arterial hypertension and iron deficiency. [PDF]

, 2015
In patients with idiopathic pulmonary arterial hypertension (iPAH), iron deficiency is common and has been associated with reduced exercise capacity and worse survival. Previous studies have shown beneficial effects of intravenous iron administration. In
Ruiter, G, van der Laarse, W.J., Howard, LS, Vonk‐Noordegraaf Anton, Chris M. Happé, Happe, C.M., Luke S. Howard, Westerhof, N, Schalij, I, Howard, L.S., Wilkins, MR, Emmy Manders, Ruiter, G., van der Laarse, WJ, Westerhof, N., Schalij, I., Manders, E, Happé, CM, Harm J. Bogaard, Bogaard, HJ, de Man, FS, Wilkins, M.R., Groepenhoff, H, Bogaard, H.J., de Man, F.S., Gerrina Ruiter, Herman Groepenhoff, Frances S. de Man, Vonk-Noordegraaf, A, Vonk-Noordegraaf, A., Willem J. van der Laarse, Ingrid Schalij, Manders, E., Groepenhoff, H., Nico Westerhof, Martin R. Wilkins   +35 more
core   +1 more source

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, EarlyView.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
core   +2 more sources