Results 101 to 110 of about 23,810 (346)

Persistent pulmonary hypertension of the newborn

open access: yesJournal of the Formosan Medical Association, 2013
Persistent pulmonary hypertension of the newborn (PPHN) is a severe pulmonary disorder which occurs at a rate of one in every 500 live births. About 10–50% of the victims will die of the problem and 7–20% of the survivors develop long-term impairments ...
Ru-Jeng Teng, Tzong-Jin Wu
doaj   +1 more source

Acute pulmonary pathology and sudden death in rats following the intravenous administration of the plasticizer, DI (2-ethylhexyl) phthalate, solubilized with Tween surfactants [PDF]

open access: yes
Intravenous administration of 200-300 mg/kg of di(2-ethylhexyl)phthalate (DEHP) solubilized in aqueous solutions of several Tween surfactants caused respiratory distress in rats.
Hutchins, G. M.   +2 more
core   +1 more source

Catechol Derivative‐Based Bioadhesives: Molecular Design for Precision Medical Adhesion

open access: yesAdvanced Science, EarlyView.
This study utilizes tree‐inspired side‐chain engineering to graft five catechol derivatives onto PVA, systematically revealing how side‐chain length and substituents regulate adhesion and cohesion properties. Among them, the PVA‐CA patch demonstrates superior tissue adhesion, biocompatibility, and promotes regeneration, establishing a programmable ...
Xueyu Wang   +8 more
wiley   +1 more source

The effect of a peptide-containing synthetic lung surfactant on gas exchange and lung mechanics in a rabbit model of surfactant depletion

open access: yesDrug Design, Development and Therapy, 2013
Johann M van Zyl,1 Johan Smith,2 Arthur Hawtrey1 1Division of Pharmacology, 2Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa Background: Currently, a new generation of synthetic pulmonary surfactants is being ...
van Zyl JM, Smith J, Hawtrey A
doaj  

A model of flow and surfactant transport in an oscillatory alveolus partially filled with liquid [PDF]

open access: yes, 2005
The flow and transport in an alveolus are of fundamental importance to partial liquid ventilation, surfactant transport, pulmonary drug administration, cell-cell signaling pathways, and gene therapy.
Fujioka, Hideki   +3 more
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

open access: yesAdvanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi   +7 more
wiley   +1 more source

Fluorescent visualization of a spreading surfactant

open access: yes, 2010
The spreading of surfactants on thin films is an industrially and medically important phenomenon, but the dynamics are highly nonlinear and visualization of the surfactant dynamics has been a long-standing experimental challenge.
Adele M Lichtenberger   +6 more
core   +1 more source

Tuning aerosol particle size distribution of metered dose inhalers using cosolvents and surfactants [PDF]

open access: yes, 2013
OBJECTIVES: The purpose of these studies was to understand the influence of cosolvent and surfactant contributions to particle size distributions emitted from solution metered dose inhalers (pMDIs) based on the propellant HFA 227.
Saleem, IY, smyth, HD
core   +2 more sources

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

open access: yesAdvanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang   +23 more
wiley   +1 more source

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