Results 71 to 80 of about 592,819 (238)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Aerosol delivery of dry powder synthetic lung surfactant to surfactant-deficient rabbits and preterm lambs on non-invasive respiratory support [version 2; referees: 3 approved]

Gates Open Research, 2019
Background: The development of synthetic lung surfactant for preterm infants has focused on peptide analogues of native surfactant proteins B and C (SP-B and SP-C).
Frans J. Walther, Monik Gupta, Michael M. Lipp, Holly Chan, John Krzewick, Larry M. Gordon, Alan J. Waring   +6 more
doaj   +1 more source

EXPRESS: Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI) [PDF]

, 2019
Pulmonary hypertension is highly heterogeneous and despite treatment advances it remains a life shortening condition. There have been significant advances in imaging technologies, but despite evidence of their potential clinical utility practice remains
Swift, Andrew J., van Beek, Edwin, Olschewski, H., Horst Olschewski, Kiely, D., Screaton, Nicholas J, Michal Schafer, Rahaghi, F., David G. Kiely, Rebecca Vandepool, Tawhai, M., Mazurek, Jeremy, Rahaghi, Farbod N., Vogel-Claussen, J., Swift, Andrew, Levin, David L., Tawhai, Merryn, Ivy, David D, Andrew J. Swift, Swift, A., Van Beek, Edwin Jr, Angela Lungu, Schiebler, Mark, Schiebler, M., Bwika, J., Jone, P.-N., Dunbar Ivy, Kawut, S.M., Peacock, Andrew J., Stephen J. Wort, Kiely, David, Levin, D., Wild, J., David L. Levin, Puri, G D, Wild, Jim M, Olschewski, Horst, Schafer, M., Vanderpool, R.R., Vonk-Noordegraaf, Anton, G.D. Puri, Wort, John, Peacock, A., Hassoun, Paul M, Hassoun, Paul, Hassoun, Paul M., Jone, Pei-Ni, Lungu, Angela, Vanderpool, Rebecca R, Moledina, S., Bwika, Jumaa, Schiebler, Mark L, Kiely, David G., Shahin Moledina, Farbod N. Rahaghi, Jim Lordan, Levin, David, Jens Vogel‐Claussen, Kawut, Steven M, Rahaghi, Farbod N, Wort, J., Ivy, D.D., Wild, Jim, Pei‐Ni Jone, Kawut, Steven M., Andrew J. Peacock, Puri, Goverdhan Dutt, Mazurek, J., Jumaa Bwika, Lordan, Jim, Zhao, Lan, Tawhi, Merryn, Dunbar, Ivy, Van Beek, E.J., Mazurek, Jeremy A, Screaton, Nicholas, Vonk-Noordegraaf, A., Rahaghi, Farbod, Steven M. Kawut, Zhao, L., Anton Vonk‐Noordegraaf, Wort, Stephen J., Vandepool, Rebecca, Ivy, Dunbar, Wort, S John, Lordan, J., Wild, Jim M., Moledina, Shahin, van Beek, Edwin J. R., Schafer, Michal, Kiely, David G, Paul M. Hassoun, Jim M. Wild, Swift, Andrew J, Puri, G. D., Vogel-Claussen, Jens, Jeremy A. Mazurek, Lungu, A., Puri, G.D., Screaton, N., Mazurek, Jeremy A., Nicholas Screaton, Merryn Tawhai, Hassoun, P., Mark Schiebler, Peacock, Andrew, Lan Zhao, Edwin J.R. van Beek   +107 more
core   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

A multicenter, randomized, double-blind trial of a new porcine surfactant in premature infants with respiratory distress syndrome

Einstein (São Paulo)
Objective To compare the efficacy and safety of a new porcine-derived pulmonary surfactant developed by Instituto Butantan with those of animal-derived surfactants commercially available in Brazil, regarding neonatal mortality and the major complications
Celso Moura Rebello, Alexander Roberto Precioso, Renata Suman Mascaretti   +2 more
doaj   +1 more source

Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant

Respiratory Research, 2007
Background Deleted in Malignant Brain Tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds various bacteria and is thought to participate in innate pulmonary host defense.
Griese Matthias, Hartl Dominik, Weiss Christel, Gassler Nikolaus, Helmke Burkhard M, Renner Marcus, End Caroline, Müller Hanna, Hafner Mathias, Poustka Annemarie, Mollenhauer Jan, Poeschl Johannes   +11 more
doaj   +1 more source

Comparative efficacy of pulmonary surfactant in respiratory distress syndrome in preterm infants: a Bayesian network meta-analysis

Archives of Medical Science, 2020
Introduction The comparative efficacy of pulmonary surfactant in the treatment of respiratory distress syndrome in preterm infants remains unclear. We aimed to evaluate the effectiveness of different pulmonary surfactant in the treatment of respiratory ...
Caihong Qiu, Cui Ma, Nana Fan, Xiaoyu Zhang, Guofeng Zheng   +4 more
doaj   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Microfluidic Gratings for X‐Ray Phase Contrast Imaging

Advanced Science, EarlyView.
This work establishes a new protocol for the fabrication of X‐ray gratings that exploits the advantages of microfluidics and enables a more inexpensive, faster, and scalable production process. These X‐ray devices are fundamental for implementing X‐ray phase contrast imaging (XPCI) in laboratory and clinical settings, yet their costly and complex ...
Alessandro Rossi, Antonio Ferraro, Francesco Coccimiglio, Tiziana Ritacco, Alberto Astolfo, Michele Giocondo, Vincenzo Formoso, Raffaele Giuseppe Agostino, Francesco Iacoviello, Ioannis Papakonstantinou, Alessandro Olivo   +10 more
wiley   +1 more source

Persistent pulmonary hypertension of the newborn

Journal of the Formosan Medical Association, 2013
Persistent pulmonary hypertension of the newborn (PPHN) is a severe pulmonary disorder which occurs at a rate of one in every 500 live births. About 10–50% of the victims will die of the problem and 7–20% of the survivors develop long-term impairments ...
Ru-Jeng Teng, Tzong-Jin Wu
doaj   +1 more source