Results 61 to 70 of about 647,511 (278)
Advanced Science, EarlyView.This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao +12 more
wiley +1 more source
Advanced Science, EarlyView.Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li +7 more
wiley +1 more source
Lipid-Laden Macrophages in Pulmonary Diseases
CellsPulmonary surfactants play a crucial role in managing lung lipid metabolism, and dysregulation of this process is evident in various lung diseases. Alternations in lipid metabolism lead to pulmonary surfactant damage, resulting in hyperlipidemia in ...
Yin Zhu +3 more
doaj +1 more source
Small Science, 2021 The interplay of particles with pulmonary surfactant, a lipid‐protein material pivotal for lung function, is hypothesized as a key factor that has not been routinely considered in the current in vitro models when determining the fate of inhaled ...
Benedikt Huck +12 more
doaj +1 more source
Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli
Advanced Science, EarlyView.Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma +18 more
wiley +1 more source
, 2023 Phospholipids are part of pulmonary surfactants and alveolocytes. Determination of this marker in exhaled air condensate can be a prognostic of pulmonary complications in children with acute ...
Koval, Victoria
core +3 more sources
BMC Pediatrics, 2023 Background The benefit of surfactant replacement therapy for respiratory distress syndrome (RDS) has been demonstrated. However, some surfactants are expensive and usually inaccessible.
Fatemeh Sabzevari +5 more
doaj +1 more source
, 2012 Background: After abdominal surgery, the formation of postoperative adhesion is a serious problem. The aim of the study is to evaluate the efficacy of 2 different pulmonary surfactants, poractant and beractant, on adhesion prevention in an experimental ...
SERİN KILIÇOĞLU, SİBEL +8 more
core +1 more source
Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions
Advanced Science, EarlyView.This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu +12 more
wiley +1 more source
Extracting pulmonary surfactants to form inverse micelles on suspended graphene nanosheets
, 2018 Graphene suspended in alveoli shows size-, oxidation- and curvature-dependent performance on extracting pulmonary surfactants (PS), further inducing the PS depletion and biophysical inhibition and starting formation of the PS corona.
Xianren Zhang +7 more
core +1 more source