Results 41 to 50 of about 23,810 (346)

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Mediators of Inflammation, 2021
Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and
Mohamed M. Aboudounya, Richard J. Heads
doaj   +1 more source

Synthetic Pulmonary Surfactant Preparations: New developments and future trends [PDF]

, 2008
Pulmonary surfactant is a lipid-protein complex that coats the interior of the alveoli and enables the lungs to function properly. Upon its synthesis, lung surfactant adsorbs at the interface between the air and the hypophase, a capillary aqueous layer ...
Lukovic, Dunja, Mingarro Muñoz, Ismael, Pérez Gil, Jesús, Vilar, Marçal   +3 more
core   +1 more source

Unraveling the enigma: The emerging significance of pulmonary surfactant proteins in predicting, diagnosing, and managing COVID‐19

Immunity, Inflammation and Disease
Background Severe cases of COVID‐19 often lead to the development of acute respiratory syndrome, a critical condition believed to be caused by the harmful effects of SARS‐CoV‐2 on type II alveolar cells.
Mohammad Navid Bastani, Shahram Jalilian
doaj   +1 more source

A case of autoimmune pulmonary alveolar proteinosis with severe respiratory failure treated with segmental lung lavage and oral statin therapy

Respiratory Medicine Case Reports, 2022
Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease characterized by the accumulation of alveolar surfactants due to dysfunction of granulocyte-macrophage colony-stimulating factor-dependent cholesterol clearance.
Tomotsugu Takano, Keisuke Takeda, Satoshi Nakamura, Genta Akiyama, Nobuhisa Ando, Masashi Komori   +5 more
doaj   +1 more source

The Marangoni flow of soluble amphiphiles

, 2013
Surfactant distribution heterogeneities at a fluid/fluid interface trigger the Marangoni effect, i.e. a bulk flow due to a surface tension gradient. The influence of surfactant solubility in the bulk on these flows remains incompletely characterized ...
Cantat, Isabelle, Griffiths, Ian M., Li, Zhenzhen, Roché, Matthieu, Roux, Sébastien Le, Saint-Jalmes, Arnaud, Stone, Howard A.   +6 more
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Thermodynamically consistent description of the hydrodynamics of free surfaces covered by insoluble surfactants of high concentration [PDF]

, 2012
In this paper we propose several models that describe the dynamics of liquid films which are covered by a high concentration layer of insoluble surfactant.
Adamson A. W., Andrew J. Archer, Atkins P., Henderson D., Israelachvili J. N., Langer J. S., Manteuffel E. S. K., Mathis Plapp, Uwe Thiele   +8 more
core   +3 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretion

BMC Pulmonary Medicine, 2019
Background Bronchoalveolar lavage is a useful bronchoscopy technique. However, studies in “normal” children populations are few. Furthermore, the anti-inflammatory effects of exogenous pulmonary surfactants on the bronchoalveolar cellular components are ...
Lyné van Rensburg, Johann M. van Zyl, Johan Smith, Pierre Goussard   +3 more
doaj   +1 more source

A Deeper Insight into the Interfacial Behavior and Structural Properties of Mixed DPPC/POPC Monolayers: Implications for Respiratory Health

Membranes, 2022
1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphorcholine (POPC) are important components in pulmonary surfactants (PSs), of which the relative content is related to lung compliance.
Yingxue Geng, Yan Cao, Yingjie Li, Qun Zhao, Dan Liu, Ge Fan, Senlin Tian   +6 more
doaj   +1 more source