Results 21 to 30 of about 1,493,409 (315)
Surfactants: their critical role in enhancing drug delivery to the lungs
Therapeutic delivery, 2011 For local lung conditions and diseases, pulmonary drug delivery has been widely used for more than 50 years now. A more recent trend involves the pulmonary route as a systemic drug-delivery target.
Jay I Peters +2 more
core +2 more sources
Distribution and suitability of pulmonary surfactants as a vehicle for topically applied antibodies in healthy and SARS-CoV-2 infected rodent lungs [PDF]
European Journal of Pharmaceutical SciencesThe use of natural pulmonary surfactants (PS) as a drug delivery vehicle for biologics is a more recent therapeutic modality. Herein, we tested different contents of PS regarding their physicochemical properties under stress conditions. The PS content of
Lea-Adriana Barlang +2 more
exaly +2 more sources
Efficient Interfacially Driven Vehiculization of Corticosteroids by Pulmonary Surfactant
Langmuir, 2017 Pulmonary surfactant is a crucial system to stabilize the respiratory air-liquid interface. Furthermore, pulmonary surfactant has been proposed as an effective method for targeting drugs to the lungs.
Cruz Rodríguez, Antonio +11 more
core +2 more sources
Langmuir, 2019 Pulmonary administration is widely used for the treatment of lung diseases. The interaction between drug molecules and pulmonary surfactants affects the efficacy of the drug directly.
Pu Xu (7459589) +9 more
core +2 more sources
Safety and efficacy of pulmonary surfactant therapy for acute respiratory distress syndrome in children: a systematic review and meta-analysis [PDF]
BMC Pulmonary MedicineObjective Pulmonary surfactants (PSs) are generally known to be effective in treating newborns with acute respiratory distress syndrome (ARDS). However, their effectiveness in children remains controversial.
Xuesong Ren +5 more
doaj +2 more sources
The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants. [PDF]
Soft Matter, 2018 Inhaled nanoparticles traveling through the airways are able to reach the respiratory zone of the lungs. In such an event, the incoming particles first come into contact with the liquid lining the alveolar epithelium, the pulmonary surfactant.
F. Mousseau, J. Berret
semanticscholar +1 more source
Interfacial mechanisms for stability of surfactant-laden films. [PDF]
PLoS ONE, 2017 Thin liquid films are central to everyday life. They are ubiquitous in modern technology (pharmaceuticals, coatings), consumer products (foams, emulsions) and also serve vital biological functions (tear film of the eye, pulmonary surfactants in the lung).
M Saad Bhamla +4 more
doaj +1 more source
Jornal de Pediatria, 2001 OBJETIVO: apresentar a evolução clínica de recém-nascido portador de insuficiência respiratória grave neonatal secundária à Sindrome de Aspiração Meconial tratado por Circulação Extracorpórea por Membrana, ou, conforme o termo consagrado em língua ...
João Gilberto Maksoud-Filho +6 more
doaj +1 more source
Journal of Applied Physiology, 1982 Pulmonary surfactant reduces the surface tension of the alveolar air-liquid interface, thereby providing mechanical stability and preventing alveolar atelectasis. More than 50% of surfactant is dipalmitoyl phosphatidylcholine, a material that is capable of reducing the surface tension of the alveolar interface to uniquely low values.
P, Gutkowski, W, Lejman
openaire +4 more sources
Insights Gained Into the Treatment of COVID19 by Pulmonary Surfactant and Its Components
Frontiers in Immunology, 2022 Pulmonary surfactant constitutes an important barrier that pathogens must cross to gain access to the rest of the organism via the respiratory surface.
Dan Li +6 more
doaj +1 more source