Results 11 to 20 of about 1,493,409 (315)

Synthetic lung surfactants containing SP-B and SP-C peptides plus novel phospholipase-resistant lipids or glycerophospholipids [PDF]

PeerJ, 2016
Background This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP ...
Robert H. Notter, Rohun Gupta, Adrian L. Schwan, Zhengdong Wang, Mohanad Gh Shkoor, Frans J. Walther   +5 more
doaj   +4 more sources

Unraveling the enigma: The emerging significance of pulmonary surfactant proteins in predicting, diagnosing, and managing COVID‐19

Immunity, Inflammation and Disease
Background Severe cases of COVID‐19 often lead to the development of acute respiratory syndrome, a critical condition believed to be caused by the harmful effects of SARS‐CoV‐2 on type II alveolar cells.
Mohammad Navid Bastani, Shahram Jalilian
doaj   +2 more sources

Pulmonary Surfactant and Drug Delivery: An Interface-Assisted Carrier to Deliver Surfactant Protein SP-D Into the Airways

Frontiers in Bioengineering and Biotechnology, 2021
This work is focused on the potential use of pulmonary surfactant to deliver full-length recombinant human surfactant protein SP-D (rhSP-D) using the respiratory air-liquid interface as a shuttle.
Cristina García-Mouton, Alberto Hidalgo, Raquel Arroyo, Mercedes Echaide, Antonio Cruz, Jesús Pérez-Gil   +5 more
doaj   +2 more sources

Contact-angle hysteresis induced by pulmonary surfactants

Journal of applied physiology: respiratory, environmental and exercise physiology, 1983
Hydrophilic surfaces in the form of glass slides have been coated with monolayers of three of the major components of pulmonary surfactant, and the wettabilities of the resulting surfaces have been studied by applying a single drop of saline.
B. A. Hills
core   +2 more sources

A Comparison of the Effect of Beractant (Beracsurf) and Proctant Alpha (Curosurf) in Neonatal Respiratory Distress: A Randomized Controlled Trial [PDF]

Iranian Journal of Medical Sciences
Background: Surfactant treatment has revolutionized the management of respiratory distress syndrome (RDS) in preterm infants. The present study compared the effectiveness and adverse effects of two natural surfactants, Beracsurf and Curosurf, in ...
Khadijeh Sadat Najib, Hamide Barzegar, Mehrdad Rezaei, Marzieh Davood   +3 more
doaj   +2 more sources

The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels [PDF]

Nanomedicine, 2013
Aim: Topical administration of siRNA nanocarriers is a promising approach in the treatment of pulmonary disorders. Pulmonary surfactant, covering the entire alveolar surface of mammalian lungs, will be one of the first interfaces that siRNA nanocarriers ...
De Smedt, Stefaan, Raemdonck, Koen, Braeckmans, Kevin, Demeester, Jo, De Backer, Lynn   +4 more
core   +2 more sources

Evaluation of antitubercular drug‐loaded surfactants as inhalable drug‐delivery systems for pulmonary tuberculosis

Journal of Biomedical Materials Research - Part A, 2009
Pulmonary tuberculosis is associated with a year-long chemotherapy, poor alveolar drug levels, drug-related systemic toxicity, and patient noncompliance. In this study, exogenous pulmonary surfactant is proposed as a drug carrier for antitubercular drugs.
G Chimote, Rinti Banerjee
exaly   +2 more sources

Pulmonary Surfactant Preparations and Surfactant Therapy for ARDS in Surgical Intensive Care (a Literature Review)

Креативная хирургия и онкология, 2019
Introduction. Despite the fact that clinical studies of pulmonary surfactants conducted over many years have demonstrated their efficacy for the treatment of acute respiratory distress syndrome (ARDS) which led to their approval for use inRussia ...
O. A. Rosenberg
doaj   +3 more sources

Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles

Biochimica et Biophysica Acta, 2014
Reasonable suspicion has accumulated that inhaled nano-scale particulate matter influences the biophysical function of the pulmonary surfactant system.
Seeger, Werner, Andreas Günther, Thomas Schmehl, Ruppert, Clemens, Schmehl, Thomas, Moritz Beck-Broichsitter, Clemens Ruppert, Beck-Broichsitter, Moritz, Werner Seeger, Günther, Andreas   +9 more
core   +2 more sources

Lipid-Laden Macrophages in Pulmonary Diseases

Cells
Pulmonary surfactants play a crucial role in managing lung lipid metabolism, and dysregulation of this process is evident in various lung diseases. Alternations in lipid metabolism lead to pulmonary surfactant damage, resulting in hyperlipidemia in ...
Yin Zhu, Dooyoung Choi, Payaningal R. Somanath, Duo Zhang   +3 more
doaj   +2 more sources