Results 171 to 180 of about 647,511 (278)

Progressive Pulmonary Alveolar Proteinosis Diagnosis Masking Pneumonic Lung Carcinoma: Anchoring Bias in Critical Care

Cytopathology, EarlyView.
A presumed case of pulmonary alveolar proteinosis with clinical deterioration was ultimately identified at autopsy as pneumonic‐type pleomorphic carcinoma. This case highlights the diagnostic overlap between diffuse lung diseases and the risk of anchoring bias in critically ill patients.
Dakota Wheeler, Rhaya Murray, Teklu Legesse, Hector Mesa   +3 more
wiley   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

Lucinactant, a Synthetic Surfactant for the Treatment of Acute Respiratory Distress Syndrome Caused by COVID-19: Phase 1/2A Trial. [PDF]

JMIR Form Res
Huang YC, Morris P, Owens R, Guardia C, Keller S, Belloso W, Weinstein L, Simmons P, Simonson S.   +8 more
europepmc   +1 more source

Lung Ultrasound Practice in Australian and New Zealand Neonatal Intensive Care Units—A Survey

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Introduction Lung ultrasound (LUS) is increasingly used in neonatal intensive care units (NICUs) as a bedside, radiation‐free imaging tool for assessing respiratory conditions. Despite its advantages, data on current LUS practices in Australasian NICUs are limited. This study aimed to evaluate LUS use across NICUs in both countries.
V. Gruber, S. Morakeas, B. Schwaberger, M. B. Tracy   +3 more
wiley   +1 more source

Amorphous Solid Dispersions in Non-Oral Drug Delivery: A Critical Review Bridging Mechanistic Advantages and Gaps in Translational Evidence. [PDF]

Pharm Res
Riccio BVF, Leão AF, Klosowski AB, Boni FI, Ferreira LMB, de Souza MPC, Ferrari PC, Chorilli M.   +7 more
europepmc   +1 more source

Delivery‐Room Prophylactic Thin‐Catheter Surfactant in Extremely Preterm Infants: A Multicentre Pilot Randomised Controlled Trial

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To determine the effectiveness and feasibility of prophylactic thin‐catheter surfactant (TC‐S) in the delivery room in preventing intubation and mechanical ventilation in the first week after birth in extreme preterm infants. Methods The Extreme Preterm Infants Non‐invasive Surfactant Trial (EPINIST) was a pilot randomised controlled trial
Joseph K. Tauro, David A. Osborn, Jennifer Middleton, Haribalakrishna Balasubramanian, Mohamed E. Abdel‐Latif   +4 more
wiley   +1 more source

Design-Expert^® Optimization of Tamoxifen-Loaded Transethosomal Gels: A Promising Transdermal System with Cytotoxicity and Stability Validation. [PDF]

Pharmaceutics
Abou Assi R, Farhan AB, Darweesh KA, Hassan AH, Chan SY.   +4 more
europepmc   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Reevaluating PRRSV-induced respiratory distress: beyond interstitial pneumonia to pulmonary surfactant dysfunction and airway obstruction. [PDF]

Front Immunol
Chen H, Li X, Cao C, Qiu L, Duan D.
europepmc   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source