Results 131 to 140 of about 206,866 (317)

Developing a framework for identifying risk factors and estimating direct economic disease burden attributable to healthcare-associated infections: a case study of a Chinese Tuberculosis hospital

Global Health Research and Policy
Healthcare-associated infections (HAIs) represent a major global health burden, which necessitate effective frameworks to identify potential risk factors and estimate the corresponding direct economic disease burden.
Nili Ren, Xinliang Liu, Yi Luo, Guofei Li, Ying Huang, Desheng Ji, Cheng Peng, Jing Sun, Hao Li   +8 more
doaj   +1 more source

Missed opportunities for tuberculosis diagnosis. [PDF]

, 2011
BACKGROUND: In high tuberculosis (TB) burden, resource-poor countries, sputum smear microscopy remains the mainstay of diagnosis. The low sensitivity of this test means that patients with smear-negative but culture-positive TB pass undetected through the
Trejos, N, Bailey, SL, Roper, MH, Moore, DAJ, Huayta, M, López Alarcón, V   +5 more
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LncRNA NORAD Enhances Inflammatory Injury in Sepsis‐Associated Acute Lung Damage Through miR‐150‐5p/STAT1‐Dependent NF‐κB Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu, Xi‐Xi Chen, Gui‐Hua Wei, Feng Li, Hai‐Yan Zong   +4 more
wiley   +1 more source

Optimal tuberculosis case-finding methodologies for field trials of new tuberculosis vaccines in young children [PDF]

, 2013
Includes bibliographical references.There is paucity of evidence to guide case-finding strategies in field trials of new tuberculosis vaccines conducted in young children.
Moyo, Sizulu
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Transforming Musculoskeletal Disorder Management With Multimodal AI Platform for Early Diagnosis, Self‐Screening, and Personalized Care

Med Research, EarlyView.
We developed a multimodal large language model‐enabled framework for the early detection, self‐screening, and personalized management of major musculoskeletal disorders, including osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OP).
Pengyuan Xu, Guang Yang, Ge Zhang, Yafang Zhao, Pu Wan, Guiyun Zhou, Mengjie Jiang, Yixin Zhang, Zhaoyang Wang, Yichen Dai, Xiqing Zhao, Ziliang Fu, Ziyu Zheng, Ziyun Xu, Ruisi Dong, Xiaojie Xia, Duo Zhang, Yisheng He, Michael Moran, Qiguang Wang, Tim Woodfield, Khoon Lim, Tiantian Kong, Junnan Tang, Kang Tian, Kai Zhou, Hao Chi, Pengpeng Zhang, Jianhua Yang, Mingliang Zhang, Moyan Li, Yuan Cheng, Xiaolin Cui   +32 more
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Investigating Tuberculosis Dynamics Under Various Control Strategies: A Comprehensive Analysis Using Real Statistical Data

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In the present investigation, a mathematical model with vaccination, treatment, and environmental impact under real data is presented. Initially, we present the model without any interventions, followed by an examination of its equilibrium points.
Bashir Al‐Hdaibat, Mahmoud H. DarAssi, Irfan Ahmad, Muhammad Altaf Khan, Reem Algethamie   +4 more
wiley   +1 more source

Clinical Value of Metagenomic Next‐Generation Sequencing Versus Conventional Methods in Diagnosing Cryptococcal Infection After Kidney Transplantation

Organ Medicine, EarlyView.
This retrospective study evaluated metagenomic next‑generation sequencing (mNGS) against conventional methods (India ink, culture, antigen) for diagnosing cryptococcal infection in 16 kidney transplant recipients. mNGS showed a significantly higher positivity rate (93.8% vs 62.5%, p = 0.031) and shorter turnaround time (24 vs. 120 h, p < 0.001).
Luhao Liu, Rongxin Chen, Haonan Lin, Yuhe Guo, Guanghui Li, Jiali Fang, Zheng Chen   +6 more
wiley   +1 more source

Factors Associated with Delay in Diagnosis of Tuberculosis in Ardabil Province [PDF]

Background and objectives: Transmission of tuberculosis occurs usually by aerosols, Produced with patient’s cough. So early diagnosis and proper treatment of patients as a disease reservoir, has a special importance.
معینی جزنی, آرزو, مؤیدنیا, ناصر, قبادی مراللو, حسن, پورفرضی, فرهاد, کمال نیا, فرنگیس, پورمحمد جان, ناهید, مهرپور, روشنک, علاف اصغری, امین, غریبانی, مجید محمد, جمالی, اسماعیل, صادقی, اکرم, خلیق, نغمه, آقابالايی, محرم, اناری, حسن, حضرتی, صادق, صالح زاده, فرهاد, بهبودی, صائمه, براک, منوچهر, قاسمی, احمد, رفیعی, مهدی, حبیب زاده, شهرام, میرزا آقازاده, محمد, خانجانیان, گیتا   +22 more
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Cigarette smoke and human pulmonary immune responses to mycobacteria [PDF]

, 2011
Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells ...
Van Zyl-Smit, Richard Nellis
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