Results 41 to 50 of about 169,884 (264)

Optimized anti-tuberculosis duration for drug-susceptible pulmonary tuberculosis-diabetes mellitus comorbidities: study protocol for a multicenter randomized controlled trial

BMC Pulmonary Medicine
Background The coexistence of tuberculosis (TB) and type 2 diabetes mellitus (DM) presents unique challenges in treatment optimization and management, given the mutual exacerbation of disease processes.
Peize Zhang, Huaifang Shi, Yongping Xie, Jiemei Liang, Qiumeng Hu, Liang Fu, Yuxiang Wang, Jie Tan, Senlin Zhan, Hongjuan Qin, Guanghui Xu, Guofang Deng   +11 more
doaj   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Bedaquiline combined with clofazimine as salvage therapy for 11 patients with nontuberculous mycobacterial lung disease

BMC Infectious Diseases
Objective We aimed to investigate the efficacy and safety of a regimen combining bedaquiline and clofazimine in the treatment of refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex(MAC) or Mycobacterium abscessus ...
Lan Yao, Yifan He, Jinghui Yang, Xubin Zheng, Xiang Shi, Wei Wei, Guoling Yang, Ruoyan Ying, Wei Sha   +8 more
doaj   +1 more source

Evaluation of Mycobacterium tuberculosis specific antigen-stimulated CD27−CD38+IFN-γ+CD4+ T cells for discrimination of active tuberculosis

BMC Infectious Diseases, 2022
Background Active tuberculosis (ATB) originates from primary Mycobacterium tuberculosis (MTB) infection or reactivation of latent tuberculosis. Besides bacteriological examination, MTB-reactive immunocytes detection can be an alternative testing for ...
Yong Fang, Na Wang, Liang Tang, Xiao-Jun Yang, Yuan Tang, Lin Li, Wen-Fei Wu, Bo Su, Wei Sha   +8 more
doaj   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Using simultaneous amplification and testing method for evaluating the treatment outcome of pulmonary tuberculosis

BMC Infectious Diseases, 2018
Background To evaluate the utility of Simultaneous Amplification and Testing (SAT-TB) Method for monitoring anti-TB treatment response. Methods Serial morning sputum specimens were obtained from 377 active pulmonary tuberculosis (PTB) cases at baseline ...
Liping Yan, Heping Xiao, Qing Zhang
doaj   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Performance of the MeltPro TB assay as initial test for diagnosis of pulmonary tuberculosis with drug-resistance detection

Molecular Medicine, 2023
Background The MeltPro TB assay (MeltPro) is a molecular rapid diagnostic test designed for detecting resistance to antituberculosis drugs. However, the performance of MeltPro as an initial diagnostic test for simultaneously detecting the presence of ...
Zhi-bin Liu, Li-ping Cheng, Hong-qiu Pan, Xiao-cui Wu, Fu-hui Lu, Jie Cao, Lei Wang, Wei Wei, Hong-yu Chen, Wei Sha, Qin Sun   +10 more
doaj   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Silicosis, Sarcoidosis, and Silicosarcoidosis Are Overlapping Diagnoses and Difficult to Differentiate

American Journal of Industrial Medicine, EarlyView.
ABSTRACT We evaluated 12 workers with documented exposure to respirable crystalline silica who were referred to a tertiary care center due to clinical suspicion of silicosis, sarcoidosis, or silicosarcoidosis. Although silica exposure is a well‐established risk factor for silicosis and has been associated with autoimmune diseases, mycobacterial ...
Guilherme Ward Leite, Eduardo Kaiser Ururahy Nunes Fonseca, Rodrigo Caruso Chate, Lavinia Clara Del Roio, Sofia de Paiva Memento Machado, Jefferson Benedito de Freitas, Ronaldo Adib Kairalla, Mário Terra‐Filho, Ubiratan Paula Santos, Rafael Futoshi Mizutani   +9 more
wiley   +1 more source