Results 41 to 50 of about 1,598,085 (291)

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

Advanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang   +12 more
wiley   +1 more source

REST IN PULMONARY TUBERCULOSIS. [PDF]

JAMA: The Journal of the American Medical Association, 1906
I wish to make a plea addressed to the general practitioner for the routine employment of rest in the open air in all active or partially arrested cases of tuberculosis. In the vast majority of cases the general practitioner is the man who is called on to diagnose and to treat these patients, and as he has been lectured, criticized and cajoled into ...
openaire   +3 more sources

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

Advanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong, Wenyan Hao, Lingqi Xu, Yingyi Yang, Zhenzhen Dong, Peng Pan, Zhenjiang Bai, Jie Huang, Kaidi Yang, Zhu Jin, Rui Kang, Qiang Shan, Jiang huai Wang, Zijian Zhou, Daolin Tang, Jian Wang, Huiting Zhou   +16 more
wiley   +1 more source

The Transcriptional Signature of Active Tuberculosis Reflects Symptom Status in Extra-Pulmonary and Pulmonary Tuberculosis

PLoS ONE, 2016
Background Mycobacterium tuberculosis infection is a leading cause of infectious death worldwide. Gene-expression microarray studies profiling the blood transcriptional response of tuberculosis (TB) patients have been undertaken in order to better ...
S. Blankley, C. Graham, J. Turner, M. Berry, C. Bloom, Zhaohui Xu, V. Pascual, J. Banchereau, D. Chaussabel, R. Breen, G. Santis, D. Blankenship, M. Lipman, A. O’Garra   +13 more
semanticscholar   +1 more source

Developing Biomaterial‐Based mRNA Delivery System for Lung Disease Treatment

Advanced Science, EarlyView.
Schematic illustration of biomaterial delivery mRNA for the treatment of lung diseases. Abstract Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery.
Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi   +7 more
wiley   +1 more source

A Nano‐Electro‐Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition

Advanced Science, EarlyView.
The nano‐electro‐platform achieves non‐destructive evolutionary screening and electro‐remodeling of tumor cells to generate extracellular vesicles with enhanced tumor‐targeting and therapeutic functions. These extracellular vesicles demonstrate remarkable efficacy in activating both macrophages and T cells, thereby orchestrating a potent immune ...
Feng Liu, Hong Sun, Bing Liu, Jing Zhang, Chengbao Wu, Shi Yan, Chengzheng Tai, Yihang Tong, Rongtai Su, Xiaowei Xiang, Han Wu, Fuqi Yao, Kuan Yang, Dedong Yin, Yuqiong Wang, Ao Xiao, Long Cheng, Xi Chen, Nan Wu, Zaizai Dong, Lingqian Chang   +20 more
wiley   +1 more source

Genetic polymorphisms of IL-17A, IL-17F, TLR4 and miR-146a in association with the risk of pulmonary tuberculosis

Scientific Reports, 2016
Genetic factors affect host susceptibility to pathogens. In this population-based case control study, we explored the genetic polymorphisms of IL-17, TLR4 and miR-146a in association with pulmonary tuberculosis in a Chinese Han population.
Min Wang, Guisheng Xu, Lingshuang Lü, Kun Xu, Yongzhong Chen, H. Pan, B. Burstrom, K. Burstrom, Jianming Wang   +8 more
semanticscholar   +1 more source

Diosgenin ameliorates silica‐induced tuberculosis in rats

Animal Models and Experimental Medicine, EarlyView.
Silicosis increases susceptibility to tuberculosis due to impaired macrophage function and oxidative stress. This study demonstrates that diosgenin, a steroidal saponin, significantly inhibits Mycobacterium smegmatis (IC₅₀ = 0.006 μg/mL), reduces lung fibrosis, and restores antioxidant enzyme levels (↑SOD, ↑CAT, ↓MDA) in silica‐exposed rats ...
Williams Asamoah Adu, Selase Ativui, Michael Ofori, George Owusu, Cynthia Amaning Danquah, Paul Poku Sampene Ossei   +5 more
wiley   +1 more source

MYOIDEMA IN PULMONARY TUBERCULOSIS. [PDF]

The Lancet, 1900
n ...
openaire   +4 more sources

Xpert® Mtb/Rif assay for pulmonary tuberculosis and rifampicin resistance in adults

Cochrane Database of Systematic Reviews, 2013
Background Accurate and rapid detection of tuberculosis (TB) and drug resistance are critical for improving patient care and decreasing the spread of TB.
K. Steingart, Hojoon Sohn, Ian Schiller, Lorie A. Kloda, C. Boehme, M. Pai, N. Dendukuri   +6 more
semanticscholar   +1 more source