Results 71 to 80 of about 206,866 (317)

Factors influencing sex differences in numbers of tuberculosis suspects at diagnostic centres in Pakistan. [PDF]

, 2012
SETTING: DOTS-reporting tuberculosis (TB) diagnostic centres across Pakistan. OBJECTIVES: To quantitatively investigate the influence of diagnostic centre characteristics on the number of female and male TB suspects registered at diagnostic centres ...
Godfrey-Faussett, P., Godfrey-Faussett, P, Sismanidis, C, Khan, M. S., Khan, MS, Sismanidis, C.   +5 more
core   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Plasma drug activity assay for treatment optimization in tuberculosis patients [PDF]

, 2011
Item does not contain fulltextLow antituberculosis (TB) drug levels are common, but their clinical significance remains unclear, and methods of measurement are resource intensive.
Scott K. Heysell, Mpagama, S., Kibiki, Gibson S, Houpt, Eric R, Mwaigwisya, S., Heysell, Scott K, Ndusilo, Norah, Pholwat, Suporn, Mwaigwisya, Solomon, Kibiki, G.S., Solomon Mwaigwisya, Suporn Pholwat, Jean Gratz, Mtabho, C., Aarnoutse, R.E., Stellah Mpagama, Heysell, S.K., Rob E. Aarnoutse, Charles Mtabho, Gratz, J., Mpagama, Stellah, Norah Ndusilo, Gratz, Jean, Houpt, E.R., Gibson S. Kibiki, Eric R. Houpt, Mtabho, Charles, Aarnoutse, Rob E, Ndusilo, N., Pholwat, S.   +29 more
core   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Associated factors for treatment delay in pulmonary tuberculosis in HIV-infected individuals: a nested case-control study. [PDF]

, 2012
BACKGROUND: The delay in initiating treatment for tuberculosis (TB) in HIV-infected individuals may lead to the development of a more severe form of the disease, with higher rates of morbidity, mortality and transmissibility. The aim of the present study
Laura Cunha Rodrigues, Líbia Vilela Moura, Miranda-Filho, Demócrito de Barros, Maruza Magda, Ricardo Arraes de Alencar Ximenes, Rodrigues Laura, Ximenes Ricardo Arraes de Alencar, Moura Líbia, Heloísa Ramos Lacerda, Lacerda, Heloísa Ramos, George Tadeu Nunes Diniz, Diniz George Tadeu, Miranda-Filho Demócrito de, Lacerda Heloísa, Maria de Fátima Pessoa Militão-Albuquerque, Magda Maruza, Moura, Líbia Vilela, Isabella Coimbra, Coimbra, Isabella, Coimbra Isabella, Militão-Albuquerque, Maria de Fátima Pessoa, Diniz, George Tadeu Nunes, Demócrito de Barros Miranda-Filho, Maruza, Magda, Militão-Albuquerque Maria de Fátima Pessoa, Rodrigues, Laura Cunha, Ximenes, Ricardo Arraes de Alencar   +26 more
core   +1 more source

Bedaquiline combined with clofazimine as salvage therapy for 11 patients with nontuberculous mycobacterial lung disease

BMC Infectious Diseases
Objective We aimed to investigate the efficacy and safety of a regimen combining bedaquiline and clofazimine in the treatment of refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex(MAC) or Mycobacterium abscessus ...
Lan Yao, Yifan He, Jinghui Yang, Xubin Zheng, Xiang Shi, Wei Wei, Guoling Yang, Ruoyan Ying, Wei Sha   +8 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Evaluation of Mycobacterium tuberculosis specific antigen-stimulated CD27−CD38+IFN-γ+CD4+ T cells for discrimination of active tuberculosis

BMC Infectious Diseases, 2022
Background Active tuberculosis (ATB) originates from primary Mycobacterium tuberculosis (MTB) infection or reactivation of latent tuberculosis. Besides bacteriological examination, MTB-reactive immunocytes detection can be an alternative testing for ...
Yong Fang, Na Wang, Liang Tang, Xiao-Jun Yang, Yuan Tang, Lin Li, Wen-Fei Wu, Bo Su, Wei Sha   +8 more
doaj   +1 more source

ICHTHYOL IN PULMONARY TUBERCULOSIS [PDF]

The American Journal of the Medical Sciences, 1896
n ...
openaire   +2 more sources

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source