Results 161 to 170 of about 4,197,466 (259)

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Adults with Fontan circulation: prognostic value of exercise pulmonary vascular resistance index. [PDF]

Eur Heart J
Cao JY, Egbe AC, Olsen N, Jain CC, Borlaug BA, Reddy YNV, Connolly HC, Celermajer D, Cordina R, Miranda WR.   +9 more
europepmc   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Echocardiographic evaluation of pulmonary vascular resistance in 459 dogs with Doppler-derived pulmonary hypertension. [PDF]

J Vet Intern Med
Stavri A, Krasnow M, Schober KE.
europepmc   +1 more source

Omics and Extreme Phenotyping Reveal Longitudinal Association Between Left Atrial Size and Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension. [PDF]

J Am Heart Assoc, 2023
Kelly NJ, Newhouse D, Chapagain H, Patel A, Tang Y, Howard A, Kirillova A, Kim HJ, Rahman H, El Khoury W, Nouraie SM, Hickey G, Sade LE, Jain S, Chan SY.   +14 more
europepmc   +1 more source

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry. [PDF]

J Am Heart Assoc
Satoh T, Sugimura K, Fukumoto Y, Abe K, Dohi Y, Dohi K, Taniguchi Y, Hashimoto A, Kato S, Nakamura K, Takama N, Hashimoto T, Yamada Y, Terui Y, Miura Y, Ishiyama M, Koyama M, Sera F, Tamura Y, Sakata Y, Hatano M, Yasuda S, Japan PH Registry Network Group 2 PH.   +22 more
europepmc   +1 more source

A novel echocardiographic estimate of pulmonary vascular resistance employing the hydraulic analogy to Ohm's law. [PDF]

Int J Cardiol Heart Vasc, 2022
Venkateshvaran A, Tossavainen E, Borneteg C, Oktay Tureli H, Vanoli D, Lund LH, Flachskampf F, Lindqvist P.   +7 more
europepmc   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

Absolute versus change in pulmonary vascular resistance in relation to European Society of Cardiology/European Respiratory Society risk change in pulmonary arterial hypertension. [PDF]

JHLT Open
Donker SCM, Wild CJB, Augustine DX, Suntharalingam J, Ross RVM, van Dijk APJ, Maxwell JD, Oxborough D, Thijssen DHJ.   +8 more
europepmc   +1 more source