Tryptophan metabolism: a potential link between the gut microbiota and pulmonary vascular remodeling in pulmonary hypertension [PDF]
Frontiers in Cellular and Infection MicrobiologyPulmonary hypertension (PH) comprises a group of cardiopulmonary disorders characterized by a sustained increase in pulmonary vascular resistance and pulmonary vascular remodeling, with disease progression potentially leading to right heart failure and ...
Hui Zhang +11 more
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A novel role for decadienyl-L-carnitine in pulmonary vascular remodeling and the underlying interventional mechanism of osthole [PDF]
Chinese MedicineBackground Pulmonary hypertension (PH) is a severe pulmonary vascular disease lacking early diagnostic biomarker and effective therapeutics. Osthole has capability to alleviate pulmonary vascular remodeling targeting by decadienyl-L-carnitin (C10:2) in ...
Yuan Li +6 more
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Echinacoside Improves Pulmonary Vascular Remodeling by Regulating the L‐ and T‐Type Ca2+ Channels in the Prevention and Treatment of Pulmonary Hypertension [PDF]
Pulmonary CirculationThe typical pathology of pulmonary hypertension (PH) is characterized by pulmonary vasoconstriction and irreversible pulmonary vascular remodeling. Vascular remodeling is the process of structural changes and cellular rearrangement of blood vessels due ...
Yuefu Zhao +10 more
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Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During Pulmonary Hypertension [PDF]
Advanced SciencePulmonary hypertension (PH) is a severe disease characterized by pulmonary vascular remodeling in which various immune cells play a critical role in vascular remodeling, although the details are still vague.
Yu Guo +13 more
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HMGB1 drives pulmonary arterial smooth muscle cell proliferation and migration via the MAP2K3/p38 pathway in pulmonary vascular remodeling [PDF]
Scientific ReportsPulmonary vascular remodeling (PVR) is primarily driven by the aberrant proliferation and migration of vascular cells, with pulmonary artery smooth muscle cells (PASMCs) playing a central role.
Ya-Mei Wang +6 more
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Keratin 17 Methyltransferasean14 Methylation Axis: A Novel Mechanism in Pulmonary Vascular Remodeling [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Pulmonary hypertension is a malignant cardiovascular disease characterized by pulmonary vascular remodeling, with core pathological features including pulmonary arterial wall thickening and elevated pulmonary vascular remodeling due to ...
Yun Liu +9 more
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GATA2 participates in protection against hypoxia-induced pulmonary vascular remodeling. [PDF]
PLoS ONEThe vascular endothelium is vital for cardio-pulmonary homeostasis and, thus, plays a crucial role in preventing life-threatening lung diseases.
Yuko Shirota +3 more
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Zhishi Xiebai Guizhi Decoction modulates hypoxia and lipid toxicity to alleviate pulmonary vascular remodeling of pulmonary hypertension in rats [PDF]
Chinese MedicineBackground Pulmonary hypertension (PH) is a severe cardio-pulmonary vascular disease, involves complex molecular mechanism especially during the pathological process of pulmonary vascular remodeling, brings a significant challenge to clinical treatment ...
Min Fu +9 more
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Respiratory Research, 2021 Background Hypoxic pulmonary hypertension (HPH) is a common type of pulmonary hypertension and characterized by pulmonary vascular remodeling and constriction. Alveolar epithelial cells (AECs) primarily sense alveolar hypoxia, but the role of AECs in HPH
Yanxia Wang +8 more
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Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling
Antioxidants, 2023 Pulmonary vascular remodeling, characterized by the thickening of all three layers of the blood vessel wall, plays a central role in the pathogenesis of pulmonary hypertension (PH).
Qin Fang +9 more
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