Results 31 to 40 of about 1,773,773 (285)

Pulmonary vascular remodeling in pulmonary hypertension [PDF]

open access: yesCell and Tissue Research, 2016
Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with the interplay of inflammatory cells. This review examines the pathology of these changes and highlights some of the pathogenetic mechanisms that underlie the remodeling process.
openaire   +2 more sources

Transcription factors and potential therapeutic targets for pulmonary hypertension

open access: yesFrontiers in Cell and Developmental Biology, 2023
Pulmonary hypertension (PH) is a refractory and fatal disease characterized by excessive pulmonary arterial cell remodeling. Uncontrolled proliferation and hypertrophy of pulmonary arterial smooth muscle cells (PASMCs), dysfunction of pulmonary arterial ...
Liu Yang   +5 more
doaj   +1 more source

Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema [PDF]

open access: yes, 2012
We have shown previously that hypoxia inhibits the growth of distal human pulmonary artery smooth muscle cells (PASMC) isolated under standard normoxic conditions (PASMCnorm).
N. W. Morrell   +23 more
core   +1 more source

Purinergic Dysfunction in Pulmonary Arterial Hypertension

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Pulmonary arterial hypertension (PAH) is a life‐threatening disease characterized by increased pulmonary arterial pressure and pulmonary vascular resistance, which result in an increase in afterload imposed onto the right ventricle, leading to right ...
Zongye Cai   +4 more
doaj   +1 more source

Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis [PDF]

open access: yesThorax, 2013
Background Pulmonary hypertension in idiopathic pulmonary fibrosis (IPF) is indicative of a poor prognosis. Recent evidence suggests that tetrahydrobiopterin (BH4), the cofactor of nitric oxide synthase (NOS), is involved in pulmonary hypertension and that pulmonary artery endothelial-to-mesenchymal transition (EnMT)
Almudever, Patricia   +7 more
openaire   +4 more sources

Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. [PDF]

open access: yes, 2005
BACKGROUND: Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur.
Shakur, B Haleema   +17 more
core   +2 more sources

Tetrahydrocurcumin protects against cadmium-induced hypertension, raised arterial stiffness and vascular remodeling in mice [PDF]

open access: yes, 2012
Copyright: 2014 Sangartit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and repro- duction in any medium, provided the original author and ...
Renata Guerra-Sá   +580 more
core   +15 more sources

Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling. [PDF]

open access: yes, 2017
Schistosomiasis (bilharzia) is a neglected parasitic disease caused by trematode flatworms of the genus Schistosoma which affects over 240 million people worldwide. It is characterized by the formation of inflammatory granulomas around deposited parasite
Alistair Mathie   +21 more
core   +1 more source

Retracted: CD248 as a novel therapeutic target in pulmonary arterial hypertension

open access: yesClinical and Translational Medicine, 2020
Pulmonary vascular remodeling is the most important pathological characteristic of pulmonary arterial hypertension (PAH). No effective treatment for PAH is currently available because the mechanism underlying vascular remodeling is not completely clear ...
Tao Xu   +8 more
doaj   +1 more source

Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension

open access: yesRespiratory Research, 2023
Background Pulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH), is a type of pulmonary vascular disease characterized by abnormal contraction and remodeling of the pulmonary arterioles, manifested by pulmonary vascular resistance ...
Cheng Zeng   +4 more
doaj   +1 more source

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