Results 41 to 50 of about 1,773,773 (285)

Therapeutic targeting of mineralocorticoid receptors in pulmonary hypertension: Insights from basic research

Frontiers in Cardiovascular Medicine, 2023
Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and associated with adverse outcomes. In patients with PH, plasma aldosterone levels are elevated, suggesting that aldosterone and its receptor, the mineralocorticoid receptor (
Argen Mamazhakypov, Achim Lother, Achim Lother   +2 more
doaj   +1 more source

Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Platelet‐derived growth factor is a major regulator of the vascular remodeling associated with pulmonary arterial hypertension. We previously showed that protein widely 1 (PW1+) vascular progenitor cells participate in early vessel ...
Julien Solinc, Jessica Raimbault‐Machado, France Dierick, Lamiaa El Bernoussi, Ly Tu, Raphaël Thuillet, Nathalie Mougenot, Bénédicte Hoareau‐Coudert, Virginie Monceau, Catherine Pavoine, Fabrice Atassi, David Sassoon, Giovanna Marazzi, Richard P. Harvey, Peter Schofield, Daniel Christ, Marc Humbert, Christophe Guignabert, Florent Soubrier, Sophie Nadaud   +19 more
doaj   +1 more source

Obstruction-Induced Pulmonary Vascular Remodeling

Journal of Biomechanical Engineering, 2011
Pulmonary obstruction occurs in many common forms of congenital heart disease. In this study, pulmonary artery (PA) banding is used as a model for pulmonary stenosis. Significant remodeling of the vascular bed occurs as a result of a prolonged narrowing of the PAs, and here we quantify the biophysical and molecular changes proximal and distal to the ...
Ming-Jay, Chow, Yu, Zou, Huamei, He, Francis X, McGowan, David, Zurakowski, Yanhang, Zhang   +5 more
openaire   +3 more sources

RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific [PDF]

, 2004
Hypoxia induces vasoconstriction of pulmonary arteries through contraction of smooth muscle cells (SMCs). The GTPase RhoA regulates smooth muscle contractility and actin cytoskeletal remodeling through the Rho-associated kinase ( ROCK).
Bailly, K, Ridley, A J, Haworth, SG, Ridley, AJ, Hall, SM, Hall, S M, Haworth, S G   +6 more
core   +1 more source

Stim-activated TRPC-ORAI channels in pulmonary hypertension induced by chronic intermittent hypoxia

Pulmonary Circulation, 2020
Obstructive sleep apnea (OSA), a breathing disorder featured by chronic intermittent hypoxia (CIH) is associated with pulmonary hypertension (PH). Rodents exposed to CIH develop pulmonary vascular remodeling and PH, but the pathogenic mechanisms are not ...
Sebastian Castillo-Galán, German A. Arenas, Roberto V. Reyes, Bernardo J. Krause, Rodrigo Iturriaga   +4 more
doaj   +1 more source

Vascular remodelling in the pathogenesis of idiopathic pulmonary fibrosis [PDF]

QJM, 2014
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible fibrosing interstitial pneumonia of unknown aetiology that usually leads to respiratory failure and death within 5 years of diagnosis. Alveolar epithelial cell injury, disruption of alveolar capillary membrane integrity and abnormal vascular repair and remodelling have all been ...
Barratt, S, Millar, A
openaire   +3 more sources

Severe asthma is associated with a remodeling of the pulmonary arteries in horses.

PLoS ONE, 2020
Pulmonary hypertension and cor pulmonale are complications of severe equine asthma, as a consequence of pulmonary hypoxic vasoconstriction. However, as pulmonary hypertension is only partially reversible by oxygen administration, other etiological ...
Serena Ceriotti, Michela Bullone, Mathilde Leclere, Francesco Ferrucci, Jean-Pierre Lavoie   +4 more
doaj   +1 more source

Antenatal Hypoxia and Pulmonary Vascular Function and Remodeling [PDF]

Current Vascular Pharmacology, 2013
This review provides evidence that antenatal hypoxia, which represents a significant and worldwide problem, causes prenatal programming of the lung. A general overview of lung development is provided along with some background regarding transcriptional and signaling systems of the lung.
Demosthenes G, Papamatheakis, Arlin B, Blood, Joon H, Kim, Sean M, Wilson   +3 more
openaire   +2 more sources

Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling

, 2022
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by (mal)adaptive remodeling of the pulmonary vasculature, which is associated with inflammation, fibrosis, thrombosis, and neovascularization.
Marta T. Gomes, Simone R. Potje, Angelia D. Lockett, Zhang, Lu, Machado, Roberto F., Lu Zhang, Roberto F. Machado, Lockett, Angelia D., Bai, Yang, Gomes, Marta T., Potje, Simone R., Yang Bai   +11 more
core   +1 more source

CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

Clinical and Experimental Hypertension, 2023
Background and Purpose Substitution of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads to activated inositol requiring enzyme 1 alpha (IRE1α) and spliced X-box binding protein 1 (XBP1s)
Weimin Yu, Qian Zhang, Yixiang Qiu, Hui Chen, Xiaoyang Huang, Li Xiao, Gang Xu, Siqi Li, Pingping Hu, Xiaoyong Tong   +9 more
doaj   +1 more source