Results 1 to 10 of about 43,031 (112)

Ubiquitin‐specific protease 7 mediates platelet‐derived growth factor‐induced pulmonary arterial smooth muscle cells proliferation [PDF]

Pulmonary Circulation, 2021
Pulmonary arterial hypertension is a devastating pulmonary vascular disease, in which the pathogenesis is complicated and unclear. Pulmonary arterial smooth muscle cells (PASMCs) proliferation is a key pathological feature of pulmonary arterial ...
Yanting Zhu, Qianqian Zhang, Xin Yan, Lu Liu, Cui Zhai, Qingting Wang, Limin Chai, Manxiang Li   +7 more
doaj   +3 more sources

hsa_circWDR37_016 Regulates Hypoxia-Induced Proliferation of Pulmonary Arterial Smooth Muscle Cells [PDF]

Cardiovascular Therapeutics, 2022
Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling of pulmonary vessel walls caused by excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Our previous clinical studies have demonstrated the importance of the
Shan-Shan Li, Shuang Liang, Yao Long, Xu Chen, Xin Jin   +4 more
doaj   +2 more sources

Aquaporin 1 confers apoptosis resistance in pulmonary arterial smooth muscle cells from the SU5416 hypoxia rat model [PDF]

Physiological Reports
Pulmonary hypertension (PH) arises from increased pulmonary vascular resistance due to contraction and remodeling of the pulmonary arteries. The structural changes include thickening of the smooth muscle layer from increased proliferation and resistance ...
Xin Yun, Shannon Niedermeyer, Manuella Ribas Andrade, Haiyang Jiang, Karthik Suresh, Todd Kolb, Mahendra Damarla, Larissa A. Shimoda   +7 more
doaj   +2 more sources

Chemical Constituents with Anti-Proliferative Activity on Pulmonary Arterial Smooth Muscle Cells from the Roots of Anthriscus sylvestris (L.) Hoffm. [PDF]

Molecules
A chemical investigation of Anthriscus sylvestris roots led to the isolation and characterization of two new nitrogen-containing phenylpropanoids (1–2) and two new phenol glycosides (8–9), along with fifteen known analogues.
Yanling Liu, Yangang Cao, Yajuan Zheng, Ying Niu, Lan Chen, Xu Chen, Xinyi Ma, Xiangda Li, Xiaoke Zheng, Weisheng Feng   +9 more
doaj   +2 more sources

NCAM1 modulates the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary hypertension [PDF]

Respiratory Research
Background Pulmonary hypertension (PH) is a malignant vascular disease characterized by pulmonary arterial remodeling. Neural cell adhesion molecule 1 (NCAM1) is a cell surface glycoprotein that is involved in a variety of diseases, including ...
Yunwei Chen, Ningxin Liu, Yunjing Yang, Lingzhi Yang, Yan Li, Zhuo Qiao, Yumin Zhang, Ailing Li, Rui Xiang, Li Wen, Wei Huang   +10 more
doaj   +2 more sources

Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension [PDF]

Frontiers in Cardiovascular Medicine
BackgroundPulmonary arterial hypertension (PAH) is a severe and rare disease in the cardiopulmonary system. Its pathogenesis involves vascular remodeling of the pulmonary artery, which results in progressive increases in pulmonary arterial pressure ...
Natsumi Shima, Aya Yamamura, Moe Fujiwara, Taiki Amano, Kazuyuki Matsumoto, Taiga Sekine, Haruka Okano, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura   +9 more
doaj   +2 more sources

Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells. [PDF]

Drug Des Devel Ther, 2021
Liu P, Huang W, Ding Y, Wu J, Liang Z, Huang Z, Xie W, Kong H.   +7 more
europepmc   +2 more sources

Extracellular matrix degradation pathways and fatty acid metabolism regulate distinct pulmonary vascular cell types in pulmonary arterial hypertension

Pulmonary Circulation, 2021
Pulmonary arterial hypertension describes a group of diseases characterised by raised pulmonary vascular resistance, resulting from vascular remodelling in the pre-capillary resistance arterioles.
Sharon Mumby, F. Perros, C. Hui, B.L. Xu, W. Xu, V Elyasigomari, A. Hautefort, G. Manaud, M. Humbert, K.F. Chung, S.J. Wort, I.M. Adcock   +11 more
doaj   +1 more source

Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. [PDF]

PLoS ONE, 2012
Bcr and Abr are GTPase activating proteins that specifically downregulate activity of the small GTPase Rac in restricted cell types in vivo. Rac1 is expressed in smooth muscle cells, a critical cell type involved in the pathogenesis of pulmonary ...
Min Yu, Dapeng Gong, Min Lim, Anna Arutyunyan, John Groffen, Nora Heisterkamp   +5 more
doaj   +1 more source

Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction. [PDF]

PLoS ONE, 2014
Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved
Jasbir D Upadhyaya, Nisha Singh, Anurag S Sikarwar, Raja Chakraborty, Sai P Pydi, Rajinder P Bhullar, Shyamala Dakshinamurti, Prashen Chelikani   +7 more
doaj   +1 more source