Results 21 to 30 of about 8,097,471 (281)
Mechanochemical alterations in lung cells during fibrogenesis [PDF]
, 2009 Màster en BiofísicaIdiopath pulmonary fibrosis (IPF) is a usually fatal disease associated with hardening of the lung tissue, epithelial injury and abnormal wound healing.
Pavelescu, Irina
core +6 more sources
An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle [PDF]
, 2007 Previous investigations on pulmonary artery smooth muscle cells have shown that nicotinic acid adenine dinucleotide diphosphate (NAADP) evokes highly localised intracellular Ca²⁺ bursts by mobilising thapsigargin-insensitive Ca²⁺ stores.
Kinnear, Nicholas P.
core +2 more sources
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
Communications Biology, 2021 Novoyatleva et al investigate the role of receptor tyrosine kinase Axl in Pulmonary arterial hypertension (PAH), finding that the small molecule inhibitor R428 reduces human pulmonary arterial smooth muscle cells proliferation and migration, but causes ...
Tatyana Novoyatleva +23 more
doaj +1 more source
Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension
Molecular Medicine Reports, 2020 Pulmonary hypertension (PH) is a life‑threatening disease that often involves vascular remodeling. Although pulmonary arterial smooth muscle cells (PASMCs) are the primary participants in vascular remodeling, their biological role is not entirely clear.
Wang, Ying +5 more
openaire +3 more sources
Pulmonary Circulation, 2020 Levels of the cAMP-responsive transcription factor, CREB, are reduced in medial smooth muscle cells in remodeled pulmonary arteries from hypertensive calves and rats with chronic hypoxia-induced pulmonary hypertension.
Chrystelle V. Garat +5 more
doaj +1 more source
Oxidative Stress and Antioxidative Therapy in Pulmonary Arterial Hypertension
Molecules, 2022 Pulmonary arterial hypertension (PAH) is clinically characterized by a progressive increase in pulmonary artery pressure, followed by right ventricular hypertrophy and subsequently right heart failure. The underlying mechanism of PAH includes endothelial
Dan Xu +6 more
doaj +1 more source
Role of smooth muscle cell p53 in pulmonary arterial hypertension
PLOS ONE, 2019 Pulmonary arterial hypertension (PAH) is characterized by remodeling and narrowing of the pulmonary arteries, which lead to elevation of right ventricular pressure, heart failure, and death. Proliferation of pulmonary artery smooth muscle cells (PASMCs) is thought to be central to the pathogenesis of PAH, although the underlying mechanisms are still ...
Takayuki Wakasugi +14 more
openaire +3 more sources
Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction [PDF]
, 2003 The linkage of vascular genes to specific functions will lead to a better understanding of cardiovascular pathophysiology. We developed an experimental model that enables the introduction of one or multiple gene(s) into vascular smooth muscle cells ...
Pohl, U., Bolz, S. S.
core +2 more sources
Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension
Pulmonary Circulation, 2020 Despite recent improvements in management of idiopathic pulmonary arterial hypertension, mortality remains high. Understanding the alterations in the transcriptome–phenotype of the key lung cells involved could provide insight into the drivers of ...
Didem Saygin +7 more
doaj +1 more source
Acta Biochimica et Biophysica Sinica, 2022 Hypoxia plays a crucial role in pulmonary vascular remodelling at the early stage of chronic obstructive pulmonary disease (COPD). Circle RNA (circRNA) has been identified to play a critical role in multiple diseases.
Wang Changguo +6 more
doaj +1 more source