Results 11 to 20 of about 8,097,471 (281)

Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway

FEBS Open Bio, 2015
Activation of the Notch3 cascade is involved in the development of pulmonary arterial hypertension by stimulating the proliferation of vascular smooth muscle cells. However, the detailed molecular mechanisms underlying this effect are still unclear.
Yang Song, Yonghong Zhang, Haoxiang Jiang, Yanting Zhu, Lu Liu, Wei Feng, Lan Yang, Yibin Wang, Manxiang Li   +8 more
doaj   +2 more sources

Potassium currents in cultured human pulmonary arterial smooth muscle cells

Journal of Applied Physiology, 1996
In this study, using whole cell and single-channel configurations of the patch-clamp technique, we characterized K+ currents (IK) in cultured human pulmonary arterial smooth muscle cells. The net whole cell outward membrane current (IKo) was activated at potentials positive to -60 mV.
W, Peng, S V, Karwande, J R, Hoidal, I S, Farrukh   +3 more
openaire   +3 more sources

Role of lipid droplets in pulmonary arterial hypertension: focusing on pulmonary artery smooth muscle cell proliferation

Lipids in Health and Disease
Pulmonary arterial hypertension (PAH) is a devastating disease complicated by pathological features such as proliferation of pulmonary artery smooth muscle cells (PASMCs), vasoconstriction, increased pulmonary artery pressure, and hypertrophic right ...
Baishi Huang, Yu Hao, Zhe Wen, Jie Dong, Shengwei Jin, Hui Li   +5 more
doaj   +3 more sources

The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension [PDF]

International Journal of Hypertension, 2020
Pulmonary hypertension (PH) is one of the most devastating cardiovascular diseases worldwide and it draws much attention from numerous scientists. As an indispensable part of pulmonary artery, smooth muscle cells are worthy of being carefully investigated.
Shixin He, Tengteng Zhu, Zhenfei Fang
openaire   +4 more sources

Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]

, 2006
KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
Joshi, Shreena, Gurney, Alison M., Balan, Prabhu   +2 more
core   +5 more sources

Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells [PDF]

Respiratory Research, 2015
Dexamethasone suppressed inflammation and haemodynamic changes in an animal model of pulmonary arterial hypertension (PAH). A major target for dexamethasone actions is NF-κB, which is activated in pulmonary vascular cells and perivascular inflammatory cells in PAH.
Price, LC, Shao, D, Meng, C, Perros, F, Garfield, BE, Zhu, J, Montani, D, Dorfmuller, P, Humbert, M, Adcock, IM, Wort, SJ   +10 more
openaire   +3 more sources

Vascular cell‐specific roles of mineralocorticoid receptors in pulmonary hypertension

Pulmonary Circulation, 2021
Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells.
Divya P. Menon, Guanming Qi, Seung K. Kim, M. Elizabeth Moss, Krishna C. Penumatsa, Rod R. Warburton, Deniz Toksoz, Jamie Wilson, Nicholas S. Hill, Iris Z. Jaffe, Ioana R. Preston   +10 more
doaj   +1 more source

Serotonin induces pulmonary artery smooth muscle cell migration [PDF]

Biochemical Pharmacology, 2006
The chronic phase of pulmonary arterial hypertension (PAH) is associated with vascular remodeling, especially thickening of the smooth muscle layer of large pulmonary arteries and muscularization of small pulmonary vessels, which normally have no associated smooth muscle.
Regina M, Day, Abena S, Agyeman, Michael J, Segel, Rubén D, Chévere, Jill M, Angelosanto, Yuichiro J, Suzuki, Barry L, Fanburg   +6 more
openaire   +2 more sources

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

Pulmonary Circulation, 2020
Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu, Haiyang Tang, Ruizhu Lin, Shane G. Carr, Ziyi Wang, Aleksandra Babicheva, Ramon J. Ayon, Pritesh P. Jain, Mingmei Xiong, Marisela Rodriguez, Shamin Rahimi, Francesca Balistrieri, Shayan Rahimi, Daniela Valdez-Jasso, Tatum S. Simonson, Ankit A. Desai, Joe G.N. Garcia, John Y.-J. Shyy, Patricia A. Thistlethwaite, Jian Wang, Ayako Makino, Jason X.-J. Yuan   +21 more
doaj   +1 more source

Osthole improves pulmonary artery hypertension by inducing apoptosis in pulmonary artery smooth muscle cells

Journal of Pharmacy and Pharmacology, 2021
Abstract Objectives The objectives of this study were to explore the effect of Osthole (Ost) on apoptosis in pulmonary artery smooth muscle cells (PASMCs) and investigate the potential mechanism of this effect.
Ling Zhu, Ye-li Li, Zhi-qiang Qian, Liang Hua, Yun Yue, Dan-li Yang   +5 more
openaire   +2 more sources