Results 31 to 40 of about 8,097,471 (281)

Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

, 2005
Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn, Kennedy, Charles, Gurney, Alison M.   +2 more
core   +5 more sources

CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats.

PLoS ONE, 2014
Successful curative treatment of severe pulmonary arterial hypertension with luminal obliteration will require a thorough understanding of the mechanism underlying the development and progression of pulmonary vascular lesions.
Daniela Farkas, Donatas Kraskauskas, Jennifer I Drake, Aysar A Alhussaini, Vita Kraskauskiene, Harm J Bogaard, Carlyne D Cool, Norbert F Voelkel, Laszlo Farkas   +8 more
doaj   +1 more source

Upregulation of IRF9 Contributes to Pulmonary Artery Smooth Muscle Cell Proliferation During Pulmonary Arterial Hypertension [PDF]

Frontiers in Pharmacology, 2021
Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a critical pathological feature in the pathogenesis of pulmonary arterial hypertension (PAH), but the regulatory mechanisms remain largely unknown. Herein, we demonstrated that interferon regulatory factor 9 (IRF9) accelerated PASMCs proliferation by regulating Prohibitin 1 ...
Yong-Jie Chen, Yong-Jie Chen, Yi Li, Xian Guo, Bo Huo, Yue Chen, Yi He, Rui Xiao, Rui Xiao, Xue-Hai Zhu, Xue-Hai Zhu, Ding-Sheng Jiang, Ding-Sheng Jiang, Xiang Wei, Xiang Wei   +14 more
openaire   +3 more sources

Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]

, 2011
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Cornelis van Breemen, Jeremy Hoskins, Arash Y. Tehrani, Mitra Esfandiarei, Yohan Choi, Nicola Fameli, Jeremy G. Hoskins, Arash Tehrani   +7 more
core   +1 more source

Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells [PDF]

, 2006
PhDEmbryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process.
Yin, Xiaoke
core   +4 more sources

Activation of GATA-4 by Serotonin in Pulmonary Artery Smooth Muscle Cells [PDF]

Journal of Biological Chemistry, 2003
Serotonin (5-hydroxytryptamine (5-HT)) is a mitogen of pulmonary artery smooth muscle cells (PASMC) and plays an important role in the development of pulmonary hypertension. Signal transduction initiated by 5-HT involves serotonin transporter-dependent generation of reactive oxygen species and activation of the MEK-ERK pathway.
Yuichiro J, Suzuki, Regina M, Day, Chia Chi, Tan, Tor H, Sandven, Qiangrong, Liang, Jeffery D, Molkentin, Barry L, Fanburg   +6 more
openaire   +2 more sources

Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching [PDF]

, 2012
Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial.
DI LAURO M. V., Maria Vittoria Di Lauro (127364), Teresa Iuvone (127378), Angelo Guglielmotti, Angelo Guglielmotti (127381), Pasquale Maffia (127384), Gianluca Grassia (127362), Cicala, C., MADDALUNO, MARCELLA, Francesco Maione, Maria Vittoria Di Lauro, Nicola Mascolo, Nicola Mascolo (127387), Maffia, P., Gianluca Grassia, Armando Ialenti, Antonio Parisi (127365), GRASSIA, GIANLUCA, Guglielmotti, A., IALENTI, ARMANDO, Grassia, G., IUVONE, TERESA, MASCOLO, NICOLA DOMENICO C. FERDINANDO, Carla Cicala (127370), Pasquale Maffia, MAIONE, FRANCESCO, Maione, F., Iuvone, T., Maddaluno, M., GUGLIELMOTTI A., Daniele De Filippis (127374), De Filippis, D., Antonio Parisi, Carla Cicala, Armando Ialenti (127390), Ialenti, A., Parisi, A., CICALA, CARLA, MAFFIA, PASQUALE, Marcella Maddaluno (127360), Marcella Maddaluno, Teresa Iuvone, PARISI A., Mascolo, N., Francesco Maione (127366), Di Lauro, M.V., Daniele De Filippis, DE FILIPPIS, DANIELE   +47 more
core   +1 more source

Original Research: Role of phosphodiesterases in modulation of BK channels in hypertensive pulmonary arterial smooth muscle

Therapeutic Advances in Respiratory Disease, 2008
BK Ca channels regulate pulmonary arterial pressure, and protein kinase C (PKC) inhibits BK Ca channels, but little is known about PKC-mediated modulation of BK Ca channel activity in pulmonary arterial smooth muscle.
Shu Zhu, Richard E. White, Scott A. Barman   +2 more
doaj   +1 more source

Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension

Antioxidants, 2019
Hyperproliferation of pulmonary arterial smooth muscle cells is a key component of vascular remodeling in the setting of pulmonary hypertension (PH). Numerous studies have explored factors governing the changes in smooth muscle cell phenotype that lead ...
John C. Huetsch, Karthik Suresh, Larissa A. Shimoda   +2 more
doaj   +1 more source

Ligustrazine alleviates pulmonary arterial hypertension in rats by promoting the formation of myocardin transcription complex in the nucleus of pulmonary artery smooth muscle cells

Clinical and Translational Science, 2023
Pulmonary arterial hypertension (PAH) is a pathophysiological state of abnormally elevated pulmonary arterial pressure caused by drugs, inflammation, toxins, viruses, hypoxia, and other risk factors.
Xichao Yu, Mingjie Wu, Qinhai Meng, Weijie Zhu, Chenyan Zhang, Bowen Liu, Yuewen Qi, Shuqun Gu, Xinyu Wang, Jingli Wen, Yu Li, Xu Qi   +11 more
doaj   +1 more source