Results 41 to 50 of about 8,097,471 (281)

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

American Journal of Respiratory Cell and Molecular Biology, 2013
Abstract Pulmonary artery (PA) smooth muscle cell (SMC) proliferation in pulmonary hypertension (PH) may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling. The mTOR pathway involves two independent complexes, mTORC1 and mTORC2, which phosphorylate S6 kinase (S6K) and serine/threonine kinase (Akt), respectively ...
Amal, Houssaini, Shariq, Abid, Nathalie, Mouraret, Feng, Wan, Dominique, Rideau, Mirna, Saker, Elisabeth, Marcos, Claire-Marie, Tissot, Jean-Luc, Dubois-Randé, Valérie, Amsellem, Serge, Adnot   +10 more
openaire   +3 more sources

Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor‐2: Involvement in HIV‐Associated Pulmonary Vascular Remodeling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundEarlier, we reported that the simultaneous exposure of pulmonary arterial smooth muscle cells to HIV proteins and cocaine results in the attenuation of antiproliferative bone morphogenetic protein receptor‐2 (BMPR2) protein expression without ...
Mahendran Chinnappan, Aradhana Mohan, Stuti Agarwal, Pranjali Dalvi, Navneet K. Dhillon   +4 more
doaj   +1 more source

Free radical production in hypoxic pulmonary artery smooth muscle cells [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000
This study used an inexpensive and versatile environmental exposure system to test the hypothesis that hypoxia promoted free radical production in primary cultures of rat main pulmonary artery smooth muscle cells (PASMCs). Production of reactive species was detected by fluorescence microscopy with the probe 2′,7′-dichlorodihydrofluorescein, which is ...
D W, Killilea, R, Hester, R, Balczon, P, Babal, M N, Gillespie   +4 more
openaire   +2 more sources

Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation. [PDF]

PLoS ONE, 2012
Pulmonary Arterial Hypertension (PAH) is a progressive devastating disease characterized by excessive proliferation of the Pulmonary Arterial Smooth Muscle Cells (PASMCs).
Samuel Jalali, Gurukumar K Ramanathan, Prasanna Tamarapu Parthasarathy, Salman Aljubran, Lakshmi Galam, Asfiya Yunus, Sara Garcia, Ruan R Cox, Richard F Lockey, Narasaiah Kolliputi   +9 more
doaj   +1 more source

Transgelin Exacerbates Pulmonary Artery Smooth Muscle Cell Dysfunction in Shunt-Related Pulmonary Arterial Hypertension

ESC Heart Failure, 2022
Abstract Aims Orchestrating the transition from reversible medial hypertrophy to irreversible plexiform lesions is crucial for pulmonary arterial hypertension related to congenital heart disease (CHD-PAH).
Jing‐jing Zhou, Jian Yang, Li Li, Rui‐lin Quan, Xiao‐xi Chen, Yu‐ling Qian, Li Huang, Pei‐he Wang, Yue Li, Xian‐min Meng, Xi Chen, Qing Gu, Jian‐Guo He   +12 more
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Transcription factors and potential therapeutic targets for pulmonary hypertension

Frontiers in Cell and Developmental Biology, 2023
Pulmonary hypertension (PH) is a refractory and fatal disease characterized by excessive pulmonary arterial cell remodeling. Uncontrolled proliferation and hypertrophy of pulmonary arterial smooth muscle cells (PASMCs), dysfunction of pulmonary arterial ...
Liu Yang, Naifu Wan, Fanpeng Gong, Xianfeng Wang, Lei Feng, Guizhu Liu   +5 more
doaj   +1 more source

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice [PDF]

Journal of Visualized Experiments, 2013
Pulmonary hypertension is a significant cause of morbidity and mortality in infants. Historically, there has been significant study of the signaling pathways involved in vascular smooth muscle contraction in PASMC from fetal sheep. While sheep make an excellent model of term pulmonary hypertension, they are very expensive and lack the advantage of ...
Keng Jin, Lee, Lyubov, Czech, Gregory B, Waypa, Kathryn N, Farrow   +3 more
openaire   +2 more sources

Salt-inducible kinase 1 deficiency promotes vascular remodeling in pulmonary arterial hypertension via enhancement of yes-associated protein-mediated proliferation

Heliyon, 2022
Pulmonary arterial remodeling at an early stage, including excessive proliferation and migration of smooth muscle cells, is a hallmark of pulmonary arterial hypertension (PAH).
Jiangqin Pu, Feng Wang, Peng Ye, Xiaomin Jiang, Wenying Zhou, Yue Gu, Shaoliang Chen   +6 more
doaj   +1 more source

Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension [PDF]

European Respiratory Journal, 2005
Pulmonary arterial hypertension (PAH) results from persistent vasoconstriction, smooth muscle growth and extracellular matrix (ECM) remodelling of pulmonary arteries (PAs). Matrix metalloproteinases (MMPs) are matrix-degrading enzymes involved in ECM turnover, and in smooth muscle cell (SMC) and endothelial cell migration and proliferation.
Lepetit, H., Eddahibi, S., Fadel, E., Frisdal, E., Munaut, Carine, Noël, Agnès, Humbert, M., Adnot, S., D'Ortho, M. P., Lafuma, C.   +9 more
openaire   +3 more sources

Impact of TASK-1 in Human Pulmonary Artery Smooth Muscle Cells [PDF]

Circulation Research, 2006
The excitability of pulmonary artery smooth muscle cells (PASMC) is regulated by potassium (K + ) conductances. Although studies suggest that background K + currents carried by 2-pore domain K + channels are important regulators of resting membrane potential in PASMC ...
Andrea, Olschewski, Yingji, Li, Bi, Tang, Jörg, Hanze, Bastian, Eul, Rainer M, Bohle, Jochen, Wilhelm, Rory E, Morty, Michael E, Brau, E Kenneth, Weir, Grazyna, Kwapiszewska, Walter, Klepetko, Werner, Seeger, Horst, Olschewski   +13 more
openaire   +2 more sources