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Vascular remodeling in pulmonary hypertension
, 2015 Pulmonary hypertension (PH) is a progressive obliterative vasculopathy with multifactorial etiology and high mortality rate. Endothelial dysfunction, excessive vascular remodeling, inflammation and in situ thrombosis contribute to increased vascular resistance and gradual occlusion of pulmonary vessels.
Ya-Ting Chang (18660718)
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Phosphodiesterase 10A Upregulation Contributes To Pulmonary Vascular Remodeling
A26. SMOOTH MUSCLE CELLS IN PULMONARY ARTERIAL HYPERTENSION: REGULATION, DIFFERENTIATION, AND PROLIFERATION, 2010 Phosphodiesterases (PDEs) modulate the cellular proliferation involved in the pathophysiology of pulmonary hypertension (PH) by hydrolyzing cAMP and cGMP. The present study was designed to determine whether any of the recently identified PDEs (PDE7-PDE11) contribute to progressive pulmonary vascular remodeling in PH.
Xia Tian +8 more
openaire +5 more sources
Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension
Pharmacology & Therapeutics, 2001 Pulmonary vascular remodelling is an important pathological feature of pulmonary hypertension, leading to increased pulmonary vascular resistance and reduced compliance. It involves thickening of all three layers of the blood vessel wall (due to hypertrophy and/or hyperplasia of the predominant cell type within each layer), as well as extracellular ...
Jeffery, T.K., Wanstall, J.C.
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Vascular remodeling in pulmonary hypertension [PDF]
Journal of Molecular Medicine, 2013 Pulmonary hypertension is a complex, progressive condition arising from a variety of genetic and pathogenic causes. Patients present with a spectrum of histologic and pathophysiological features, likely reflecting the diversity in underlying pathogenesis.
Larissa A, Shimoda, Steven S, Laurie
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MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling [PDF]
Cardiovascular Research, 2011 Vascular remodelling is an integral pathological process central to a number of cardiovascular diseases. The complex interplay between distinct cell populations in the vessel wall following vascular injury leads to inflammation, cellular dysfunction, pro-growth signals in the smooth muscle cell (SMC) compartment, and the acquisition of a synthetic ...
Robert A, McDonald +4 more
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Progenitor Cells in Pulmonary Vascular Remodeling [PDF]
Pulmonary Circulation, 2011 Pulmonary hypertension is characterized by cellular and structural changes in the walls of pulmonary arteries. Intimal thickening and fibrosis, medial hypertrophy and fibroproliferative changes in the adventitia are commonly observed, as is the extension of smooth muscle into the previously non‐muscularized vessels.
Yeager, Michael E. +2 more
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Acta Pharmaceutica Sinica B, 2022 Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, in which hyperproliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role.
Weimin Yu +9 more
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CENPE contributes to pulmonary vascular remodeling in pulmonary hypertension
Biochemical and Biophysical Research Communications, 2021 Hypoxic pulmonary vascular remodeling is a pathological feature of pulmonary hypertension (PH). Our results showed that centromere-associated protein E (CENPE) expression in PH patients and hypoxia-induced PH rats was significantly higher than that in normal controls.
Xiaoyu Fang +3 more
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JNK2 Regulates Vascular Remodeling in Pulmonary Hypertension [PDF]
The FASEB Journal, 2016 Structural alterations of pulmonary arterial (PA) wall are the key pathological features of pulmonary hypertension (PH). Although such vascular abnormalities correlate with heightened phosphorylation of c‐Jun N‐terminal kinases 1/2 (JNK1/2) in rat models of PH, contribution of each individual JNK isoform to the pathophysiology of ...
Mita Das +3 more
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Cells, 2020 Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling.
Ayse Ceren Mutgan +2 more
doaj +1 more source