Results 11 to 20 of about 1,773,773 (285)

Erythropoietin attenuates pulmonary vascular remodeling in experimental pulmonary arterial hypertension through interplay between endothelial progenitor cells and heme-oxygenase [PDF]

Frontiers in Pediatrics, 2015
BackgroundPulmonary arterial hypertension (PAH) is a pulmonary vascular disease with a high mortality, characterized by typical angio-proliferative lesions. Erythropoietin (EPO) attenuates pulmonary vascular remodeling in PAH. We postulated that EPO acts
Rosa L.E. Loon, Beatrijs eBartelds, Beatrijs eBartelds, Frank A.D.T.G. Wagener, Nada eAffara, Saffloer eMohaupt, Hans eWijnberg, Sebastiaan W.C. Pennings, Janny eTakens, Rolf M.F. Berger, Rolf M.F. Berger   +10 more
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Inflammatory cells and vascular remodeling in pulmonary arterial hypertension [PDF]

Jichu yixue yu linchuang
Pulmonary arterial hypertension (PAH) is a severe and progressive pulmonary vascular disease mainly characterized by a continuous increase in pulmonary vascular resistance and rise of pulmonary artery pressure caused by pulmonary arteriolar lesions ...
QIAN Xifeng, HUA Lu
doaj   +2 more sources

Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension

Cells, 2021
Pulmonary arterial hypertension (PAH) is characterized by an important occlusive vascular remodeling with the production of new endothelial cells, smooth muscle cells, myofibroblasts, and fibroblasts.
France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud   +4 more
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Reversal of pulmonary vascular remodeling in pulmonary hypertensive rats

Experimental and Molecular Pathology, 2012
Pulmonary hypertension is responsible for significant mortality and morbidity among newborns and infants. The pathology is characterized by pulmonary vascular remodeling with medial hypertrophy and adventitial thickening, leading to decreased gas exchange.
Sluiter, Ilona, van Heijst, A, Haasdijk, Remco, Buscop - van Kempen, Marjon, Boerema - de Munck, Anne, Reiss, Irwin, Tibboel, Dick, Rottier, Robbert   +7 more
openaire   +3 more sources

Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension

Cells
Pulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited.
A. Dushani C. U. Ranasinghe, T. M. Parinda B. Tennakoon, Margaret A. Schwarz   +2 more
doaj   +2 more sources

Molecular Mechanisms of Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension [PDF]

International Journal of Molecular Sciences, 2016
Pulmonary arterial hypertension (PAH) is a devastating disease that is precipitated by hypertrophic pulmonary vascular remodeling of distal arterioles to increase pulmonary artery pressure and pulmonary vascular resistance in the absence of left heart, lung parenchymal, or thromboembolic disease.
Leopold, Jane, Maron, Bradley
openaire   +5 more sources

Reactive Oxygen Species in Pulmonary Vascular Remodeling [PDF]

Comprehensive Physiology, 2013
Abstract The pathogenesis of pulmonary hypertension is a complex multifactorial process that involves the remodeling of pulmonary arteries. This remodeling process encompasses concentric medial thickening of small arterioles, neomuscularization of previously nonmuscular capillary‐like vessels, and structural wall ...
Aggarwal, Saurabh, Gross, Christine M, Sharma, Shruti, Fineman, Jeffrey R, Black, Stephen M   +4 more
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Vascular Remodeling: The Multicellular Mechanisms of Pulmonary Hypertension

International Journal of Molecular Sciences
Pulmonary hypertension (PH) is a serious cardiovascular disease caused by a variety of pathogenic factors, which is characterized by increased pulmonary vascular resistance (PVR) and progressive elevation of mean pulmonary artery pressure (mPAP). This disease can lead to right ventricular hypertrophy and, in severe cases, right heart failure and even ...
Jinjin Dai, Hongyang Chen, Jindong Fang, Shiguo Wu, Zhuangzhuang Jia   +4 more
openaire   +3 more sources

Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats [PDF]

Respiratory Research, 2011
Background CXCR4 is the receptor for chemokine CXCL12 and reportedly plays an important role in systemic vascular repair and remodeling, but the role of CXCR4 in development of pulmonary hypertension and vascular remodeling has not been fully understood.
Hales Charles A, Yu Lunyin
doaj   +3 more sources

The etiopathogenesis of pulmonary hypertension: inflammation, vascular remodeling

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2010
Pulmonary arterial hypertension (PAH) is a progressive disease marked by increased pulmonary artery resistance leading to right heart failure with a high mortality. PAH is histologically characterized by endothelial and smooth muscle cell proliferation, medial hypertrophy, inflammation, and thrombosis in situ.
Kayıkçıoğlu M., Kayikcioglu, Meral, Meral Kayikcioglu   +2 more
openaire   +3 more sources