Results 61 to 70 of about 1,773,773 (285)

sj-pdf-1-pul-10.1177_20458940211061284 - Supplemental material for Vascular remodeling of the small pulmonary arteries and measures of vascular pruning on computed tomography

, 2021
Supplemental material, sj-pdf-1-pul-10.1177_20458940211061284 for Vascular remodeling of the small pulmonary arteries and measures of vascular pruning on computed tomography by Andrew J.
Constance De Margerie-Mellon (11782365), Farbod N. Rahaghi (7012559), George R. Washko (7782278), Murray A. Mittleman (7536251), Andrew J. Synn (11782362), Paul A. VanderLaan (11782374), Mary B. Rice (11782377), Sun Young Jeong (11027958), Iny Jhun (399101), Alexander A. Bankier (11782371), Raúl San José Estépar (11782368)   +10 more
core   +1 more source

Compound xiebai capsule alleviates pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension in rats [PDF]

, 2020
Purpose: To investigate the effect of compound xiebai capsule (CXC) on pulmonary arterial vascular remodeling in a rat model of monocrotaline-mediated pulmonary arterial hypertension (PAH).Methods: PAH model was established through intraperitoneal ...
Xi, Zhaoqing, Wu, Zhouye, Zhaoqing Xi, Zhouye Wu   +3 more
core   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Targeting endothelial cells: the pathological mechanisms and therapeutic innovations in pulmonary arterial hypertension

Frontiers in Cell and Developmental Biology
Pulmonary arterial hypertension (PAH) is a fatal disease with high mortality, which is characterized by pulmonary vascular remodeling. Current clinical treatments mainly focus on dilating vascular and relieving pulmonary artery pressure.
Tianfei Fan, Longji Li, Yao Wang, Meng Lin, Fengbo Wu   +4 more
doaj   +1 more source

sj-pdf-2-pul-10.1177_20458940211061284 - Supplemental material for Vascular remodeling of the small pulmonary arteries and measures of vascular pruning on computed tomography

, 2021
Supplemental material, sj-pdf-2-pul-10.1177_20458940211061284 for Vascular remodeling of the small pulmonary arteries and measures of vascular pruning on computed tomography by Andrew J.
Constance De Margerie-Mellon (11782365), Farbod N. Rahaghi (7012559), George R. Washko (7782278), Murray A. Mittleman (7536251), Andrew J. Synn (11782362), Paul A. VanderLaan (11782374), Mary B. Rice (11782377), Sun Young Jeong (11027958), Iny Jhun (399101), Alexander A. Bankier (11782371), Raúl San José Estépar (11782368)   +10 more
core   +1 more source

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

Cinaciguat (BAY-582667) Modifies Cardiopulmonary and Systemic Circulation in Chronically Hypoxic and Pulmonary Hypertensive Neonatal Lambs in the Alto Andino

Frontiers in Physiology, 2022
Neonatal pulmonary hypertension (NPHT) is produced by sustained pulmonary vasoconstriction and increased vascular remodeling. Soluble guanylyl cyclase (sGC) participates in signaling pathways that induce vascular vasodilation and reduce vascular ...
Felipe A. Beñaldo, Claudio Araya-Quijada, Germán Ebensperger, Emilio A. Herrera, Emilio A. Herrera, Roberto V. Reyes, Fernando A. Moraga, Alexander Riquelme, Alejandro Gónzalez-Candia, Sebastián Castillo-Galán, Guillermo J. Valenzuela, María Serón-Ferré, Aníbal J. Llanos, Aníbal J. Llanos   +13 more
doaj   +1 more source

Poisson's Ratio‐Driven Control of Myogenic Differentiation and Maturation in Auxetic Metamaterials under Dynamic Mechanical Stimulation

Advanced Functional Materials, EarlyView.
This study explored how innovative “auxetic” scaffolds, which expand when stretched, influence skeletal muscle development. Researchers cultured muscle cells on different scaffold designs and applied repeated stretching over 10 days. They found that scaffold geometry affected muscle cell differentiation and fiber formation.
Maria Kalogeropoulou, Prabhdeep Kaur, Monica Boffito, Pierpaolo Fucile, Gianluca Ciardelli, Lorenzo Moroni   +5 more
wiley   +1 more source

Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) in chronic hypoxia- and antigen-mediated pulmonary vascular remodeling

Respiratory Research, 2013
Background Both chronic hypoxia and allergic inflammation induce vascular remodeling in the lung, but only chronic hypoxia appears to cause PH. We investigate the nature of the vascular remodeling and the expression and role of hypoxia-induced mitogenic ...
Angelini Daniel J, Su Qingning, Yamaji-Kegan Kazuyo, Fan Chunling, Skinner John T, Poloczek Andre, El-Haddad Hazim, Cheadle Chris, Johns Roger A   +8 more
doaj   +1 more source

CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension

Respiratory Research, 2023
Background Pulmonary arterial hypertension (PAH) is a rare but fatal cardiopulmonary disease mainly characterized by pulmonary vascular remodeling. Aberrant expression of circRNAs has been reported to play a crucial role in pulmonary vascular remodeling.
Hua Su, Huiqi Zhu, Sihao Wang, Yeping Li, Chao Yan, Jiaoyan Wang, Kejing Ying   +6 more
doaj   +1 more source