Results 71 to 80 of about 1,773,773 (285)

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Other putative significantly differential expressed genes regulating pulmonary artery remodeling and vascular contraction in this study.

, 2016
Other putative significantly differential expressed genes regulating pulmonary artery remodeling and vascular contraction in this study.
Huabin Cao (2824973), Caiying Zhang (2824976), Fei Yang (46361), Yu Zhuang (2824982), Xiaoquan Guo (2824988), Yalu Song (2824991), Tiancheng Wang (2406016), Ping Liu (156158), Huayuan Lin (2824985), Guoliang Hu (2824979), Qingyang Xiao (686993)   +10 more
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Lung Architecture Remodeling

Antioxidants, 2017
Chronic lung disorders, such as pulmonary artery hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma and neonatal bronchopulmonary dysplasia (BPD), are characterized by airway and/or vascular remodeling.
Anantha Harijith, Viswanathan Natarajan, Panfeng Fu   +2 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling

Journal of Pharmacological Sciences, 2023
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease that is characterized by vascular remodeling of the pulmonary artery. PAH remodeling is primarily caused by the excessive proliferation of pulmonary arterial smooth muscle cells ...
Akiko Kawade, Aya Yamamura, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura   +4 more
doaj   +1 more source

Pulmonary vascular remodeling.

, 2015
At 8 weeks, lungs were harvested, processed, and stained with Masson’s trichrome to examine pulmonary vascular remodeling. Representative images from A) sham and B-D) embolization models with similar patterns of remodeling, including luminal encroachment
Roger J. Hajjar (142214), Valentin Fuster (731738), Borja Ibanez (731737), Kenneth M. Fish (731735), Jaume Aguero (731734), Kiyotake Ishikawa (585834), Nadjib Hammoudi (731736), Jane A. Leopold (118049), Ana Garcia-Alvarez (241365), Lahouaria Hadri (371273)   +9 more
core   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension [PDF]

, 2018
BACKGROUND Aldosterone is a mineralocorticoid hormone critically involved in arterial blood pressure regulation. Although pharmacological aldosterone antagonism reduces mortality and morbidity among patients with severe left-sided heart failure, the ...
Norbert Weissmann, Novoyatleva, Tatyana, Ghofrani, H.A., Boehm, Mario, Braithwaite, Adam, Grimminger, F., Arnold, N., Weissmann, Norbert, Schermuly, Ralph T, Seeger, W., Seeger, Werner, Josephine Pickworth, Adam Braithwaite, Ralph T. Schermuly, Kiely, David G, Mario Boehm, Weissmann, N., Kojonazarov, Baktybek, Werner Seeger, Changwu Lu, Tatyana Novoyatleva, David G. Kiely, Friedrich Grimminger, Lu, C., Grimminger, Friedrich, Nadine Arnold, Baktybek Kojonazarov, Hossein A. Ghofrani, Pickworth, J., Schermuly, R.T., Braithwaite, A., Kiely, D.G., Ghofrani, Hossein A, Lawrie, A., Kojonazarov, B., Arnold, Nadine, Lu, Changwu, Pickworth, Josephine, Allan Lawrie, Boehm, M., Lawrie, Allan, Novoyatleva, T., Schermuly, Ralph T., Ghofrani, Hossein A., Kiely, David G.   +44 more
core   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source