Results 111 to 120 of about 933,739 (304)

Case Report: Intracardiac echocardiography-guided pulmonary vein stenting for pulmonary vein stenosis caused by a left atrial tumor

Frontiers in Cardiovascular Medicine
BackgroundPulmonary vein stenosis (PVS) caused by a cardiac tumor is rare, and experience with transcatheter pulmonary vein stenting is limited. We report a challenging case of symptomatic PVS managed with intracardiac echocardiography (ICE)–guided ...
Yoonmin Shin, Hoyoung Son, Namsik Yoon, Namsik Yoon, Juhan Kim, Juhan Kim   +5 more
doaj   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Left upper division segmentectomy with a simultaneous displaced bronchus and pulmonary arteriovenous anomalies: a case report

Journal of Cardiothoracic Surgery, 2018
Background A displaced bronchus is a rare disorder of the left upper lobe. Displaced bronchi are often accompanied by an anomaly of a pulmonary artery, but rarely of a pulmonary vein.
Kazuki Hayashi, Makoto Motoishi, Kanna Horimoto, Satoru Sawai, Jun Hanaoka   +4 more
doaj   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Experience with the autologous pulmonary vein for pulmonary arterioplasty

, 2011
Lobectomy with pulmonary artery resection and reconstruction is seldom performed in order to avoid pneumonectomy in selected cases. The aim of this study is to determine how safe and effective the graft reconstruction of the pulmonary artery is, using ...
CAPOZZI, ROSANNA, Quintili A, Francesco Puma, Rosanna Capozzi, Jacopo Vannucci, VANNUCCI, JACOPO, Alessandro Quintili, RAGUSA, Mark, Mark Ragusa, Niccolò Daddi, PUMA, Francesco, DADDI, NICCOLO', CAGINI, Lucio, Lucio Cagini   +13 more
core   +2 more sources

Surgical repair of extremely late presentation of supracardiac total anomalous pulmonary vein connection: a case series

Journal of Cardiothoracic Surgery
Background A late-presenting total anomalous pulmonary venous connection is extremely rare, and surgical repair remains a significant challenge. Cases presentation We present two cases of surgical repair for late-presenting supracardiac total anomalous ...
Dicky Fakhri, Salomo Purba, Indriwanto Sakdijan, Ardiansyah, Aditya Agam Nugraha   +4 more
doaj   +1 more source

Dissociated pulmonary vein potentials: expression of the cardiac autonomic nervous system following pulmonary vein isolation? [PDF]

, 2015
In the electrically nonisolated pulmonary veins, the cardiac autonomic system has been shown to play an important role in initiating pulmonary vein (PV) ectopy and triggering atrial fibrillation (AF).1–3 However, the effects of the cardiac autonomic ...
Peters, NS, Kanagaratnam, P, Kyriacou, A, Hayat, S, Qureshi, N, Lim, PB   +5 more
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Accidental closure of the left upper pulmonary vein with an Amplatzer atrial septal defect occluder

, 2012
We report the clinical outcome of a 46-year-old man referred for percutaneous closure of an atrial septal defect under transthoracic echocardiographic and fluoroscopic guidance, whose upper left pulmonary vein was erroneously obliterated using an ...
Praz, Fabien, Meier, Bernhard, Carlier, Marc   +2 more
core  

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source