Results 61 to 70 of about 9,727 (224)

Vascular Reconstruction in Extremity Soft Tissue Sarcomas: A Systematic Review and Single‐Arm Meta‐Analysis

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction The management of extremity soft tissue sarcomas (STS) involving major vessels presents unique challenges, historically leading to amputation. Advances in vascular reconstruction have enabled limb‐sparing surgery (LSS), but outcomes and perioperative risks remain uncertain.
Lucas Monteiro Delgado, Bernardo Fontel Pompeu, Vinícius dos Santos Macedo, Gabriel Henrique Acedo Martins, Eric Pasqualotto, Matheus Reginato Araujo, Julia Hoici Brunini, Victor Andrade Nunes, Cláudia Theis, Samuel Aguiar Junior   +9 more
wiley   +1 more source

Pulmonary hypertension phenotypes in patients with systemic sclerosis

European Respiratory Review, 2021
Pulmonary hypertension (PH) commonly affects patients with systemic sclerosis (SSc) and is associated with significant morbidity and increased mortality.
Ashraful Haque, David G. Kiely, Gabor Kovacs, A.A. Roger Thompson, Robin Condliffe   +4 more
doaj   +1 more source

Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects. [PDF]

, 2015
Pulmonary arterial hypertension (PAH) is an often fatal disorder resulting from several causes including heterogeneous genetic defects. While mutations in the bone morphogenetic protein receptor type II (BMPR2) gene are the single most common causal ...
Abdalla, Adzhubei, Aldred, Aldred, Archer, Austin, Austin, Austin, Badesch, Best, Best, Chaouat, Chen, Chida, Chida, Chidlow, Choi, Cogan, Cogan, Dahal, David, Deng, Donnelly, Drab, Drake, Elliott, Eyries, Eyries, Feng, Foletta, Frydman, Fujiwara, Germain, Girerd, Girerd, Girerd, Greenwald, Harrison, Harrison, Hinderhofer, Hong, Huang, Humbert, Ishiwata, Jones, Kabata, Koehler, Kumar, Lane, Larkin, Liu, Liu, Long, Ma, Machado, Machado, Machado, Machado, Mache, Mair, Maniatis, McLaughlin, Mercier, Minshall, Murata, Möller, Nasim, Nasim, Nishihara, Nohe, Pfarr, Pfarr, Ranchoux, Remillard, Rigueur, Rosenzweig, Rudarakanchana, Ryan, Shi, Shintani, Simonneau, Smoot, Sobolewski, Soubrier, Sztrymf, Tenorio, Thomson, Trembath, Tuder, Vonk-Noordegraaf, Wang, Wang, Wang, West, West, West, Xu, Young, Yuan, Zhao, Zhao   +100 more
core   +2 more sources

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Pulmonary Hypertension Related to Left-Sided Cardiac Pathology

Pulmonary Medicine, 2011
Pulmonary hypertension (PH) is the end result of a variety of diverse pathologic processes. The chronic elevation in pulmonary artery pressure often leads to right ventricular pressure overload and subsequent right ventricular failure. In patients with
Todd L. Kiefer, Thomas M. Bashore
doaj   +1 more source

Extracorporeal support for pulmonary resection: current indications and results. [PDF]

, 2016
Extracorporeal assistances are exponentially used for patients, with acute severe but reversible heart or lung failure, to provide more prolonged support to bridge patients to heart and/or lung transplantation.
Gonzalez, M., Gronchi, F., Krueger, T., Perentes, J.Y., Ris, H.B., Rosskopfova, P.   +5 more
core   +2 more sources

A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype

Pulmonary Circulation, 2020
Mutations in the gene encoding bone morphogenetic protein receptor type II ( BMPR2 ) have been associated with heritable pulmonary arterial hypertension (HPAH), whereas mutations in the gene encoding eukaryotic translation initiation factor 2 alpha ...
Ifeoma Oriaku, Mallory N. LeSieur, William C. Nichols, Roberto Barrios, C. Gregory Elliott, Adaani Frost   +5 more
doaj   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Defining The Dose Of Gemtuzumab Ozogamicin In Combination With Induction Chemotherapy In Acute Myeloid Leukemia: A Comparison Of 3 Mg/M2 With 6 Mg/M2 In The NCRI AML17 Trial [PDF]

, 2016
Arecent source data meta-analysis of randomized trials in adults assessing the immunoconjugate gemtuzumab ozogamicin combined with standard chemotherapy in acute myeloid leukemia showed a significant survival benefit in patients without an adverse ...
Burnett, Alan, Cavenagh, Jamie, Clark, Richard, Grp, UKNCRIAML Study, Hills, Robert, Jones, Gail, Kell, Jonathan, Khwaja, Asim, Nielsen, Ove Juul, Russell, Nigel, Thomas, Ian   +10 more
core   +3 more sources

Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu, Zhi‐Ping Jin, Shu‐Qiang Weng, Ji‐Min Zhu, Ling Dong   +4 more
wiley   +1 more source