Results 21 to 30 of about 103,613 (63)

Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration

Journal of liposome research, 2019
Yao-Da Dong, Estefania Tchung, C. Nowell, S. Kaga, Nathania J. Leong, Dharmini C. Mehta, L. M. Kaminskas, B. Boyd   +7 more
semanticscholar   +1 more source

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The working of a pulsatory liposome

Journal of Theoretical Biology, 2008
Under positive osmotic stress, a greater lipid vesicle swells to a critical diameter, when suddenly a transbilayer pore appears and grows to a maximum radius, then decreases and finally disappears. An amount of liquid was leaked out through the pore and the vesicle returns to the initial state and can start another cycle.
Dumitru Popescu
exaly   +4 more sources

Analytical Modeling of the Functioning of the Pulsatory Liposome

Romanian Journal of Physics
In this paper the analytical solutions of the differential equations are presented. These equations describe the pulsatory liposome dynamics. We consider a unilamellar liposome filled with an aqueous solution of osmotic solute inserted in a hypotonic aqueous medium. Due to the osmosis process the liposome has a cyclic evolution.
Dumitru Popescu
exaly   +3 more sources

A mathematical investigation on the active substance pulsatory release from a solution-charged liposome

BioSystems, 2019
We adopt a model in which the time evolution of a solution-charged liposome with selective permeability is seen as a sequence of two-stage cycles. In the first stage the lipid vesicle with a certain input concentration of the active substance is swelling up in an osmotic process until it reaches a size that one pore is formed on its surface. The second
Liviu Gr. Ixaru, Dumitru Popescu
exaly   +4 more sources

AN ANALYTICAL APPROACH FOR THE PULSATORY LIPOSOME IN THE PORE RADIUS HYPOTHESIS

Revue roumaine de mathématiques pures et appliquées
One considers a unilamellar liposome filled with an aqueous solution of an osmotic solute. This liposome is introduced into an aqueous medium. Due to the osmosis process, the lipid vesicle swells up to a maximum size, when a transbilayer pore suddenly appears. Part of the internal solution leaks through this pore.
Dumitru Popescu
exaly   +3 more sources

Numerical Simulation of Lifetime for the Pulsatory Liposome

Macromolecular Symposia
ABSTRACT One considers a unilamellar liposome filled with an aqueous solution of an osmotic solute. This liposome is introduced into an aqueous medium. Due to the osmosis process, the lipid vesicle swells up to a maximum size, when a transbilayer pore suddenly appears. Part of the internal solution leaks through this pore.
Diana R. Radnef‐Constantin, Simona M. Bibic, Dumitru Popescu, Elena C. Cipu   +3 more
openaire   +2 more sources

Liposome bilayer stability: emphasis on cholesterol and its alternatives

Journal of liposome research, 2023
Liposomes are spherical lipidic nanocarriers composed of natural or synthetic phospholipids with a hydrophobic bilayer and aqueous core, which are arranged into a polar head and a long hydrophobic tail, forming an amphipathic nano/micro-particle. Despite
Hamdi Nsairat, Abed Alqader Ibrahim, Areej M. Jaber, Sharif Abdelghany, Randa Atwan, N. Shalan, Hiba Abdelnabi, F. Odeh, Mohamed El-Tanani, W. Alshaer   +9 more
semanticscholar   +1 more source

Recent advances in liposome-based targeted cancer therapy

Journal of liposome research, 2023
Nano-drug delivery systems have opened new pathways for tumor treatment by overcoming some of the limitations of conventional drugs, such as physiological degradation, short half-life, and rapid release. Liposomes are promising nanocarrier systems due to
Y. Fidan, Stela Muçaj, S. Timur, R. N. Gürsoy   +3 more
semanticscholar   +1 more source

Unravelling the role of lipid composition on liposome-protein interactions

Journal of liposome research, 2023
Upon in vivo administration of nanoparticles, a protein corona forms on their surface and affects their half-life in circulation, biodistribution properties, and stability; in turn, the composition of the protein corona depends on the physico-chemical ...
V. Nele, Federica D’Aria, Virginia Campani, T. Silvestri, M. Biondi, C. Giancola, G. De Rosa   +6 more
semanticscholar   +1 more source

Arsenic trioxide liposome gels for the treatment of psoriasis in mice

Journal of liposome research, 2023
Psoriasis is a chronic, immune-mediated skin disease with no cure. Intravenous arsenic trioxide (ATO) has been used to treat psoriasis in animal studies. However, the high toxicity of ATO limits its application to clinics for systemic administration. The
Liang Liu, Fengqing Ji, Yilei Zhao, X. Hai   +3 more
semanticscholar   +1 more source